{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T20:39:39Z","timestamp":1777063179804,"version":"3.51.4"},"reference-count":39,"publisher":"BMJ","issue":"3","funder":[{"name":"The Danish Working Environment Research Fund"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2018,11,27]]},"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>We examined exposure to different types of organisational changes at work as risk factors for subsequent prescription for psychotropic medication among employees.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study population included 15\u2009038 public healthcare employees nested within 1284 work units in the Capital Region of Denmark. Multilevel mixed-effects parametric survival models were developed to examine time to prescription for psychotropic medications (anxiolytics\/hypnotics\/sedatives\/antidepressants) during the 12-month interval following exposure to organisational changes relative to no change from January to December 2013. Data on work-unit level organisational changes (including mergers, split-ups, relocation, change in management, employee lay-offs and budget cuts) were collected from work-unit managers (59% response).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Any organisational change versus no change was associated with a higher risk of psychotropic prescription (HR: 1.14, 95%\u2009CI: 1.02 to 1.26), especially change in management (HR: 1.23, 95%\u2009CI: 1.07 to 1.41). Splitting the 12-month follow-up period into two halves yielded particularly high rates of psychotropic prescription in the latter half of the follow-up, for example, any change (HR: 1.25, 95%\u2009CI: 1.11 to 1.41), change in management (HR: 1.42, 95%\u2009CI: 1.22 to 1.65), mergers (HR: 1.26, 95%\u2009CI: 1.06 to 1.50), employee lay-off (HR: 1.23, 95%\u2009CI: 1.03 to 1.46) and budget cuts (HR: 1.13, 95%\u2009CI: 1.00 to 1.41). The associations did not vary by sex.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Organisational changes in the workplace, especially change in management, may be associated with increased risk of psychotropic prescription among employees regardless of sex.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oemed-2018-105442","type":"journal-article","created":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T05:42:47Z","timestamp":1546926167000},"page":"143-150","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Work-unit organisational changes and subsequent prescriptions for psychotropic medication: a longitudinal study among public healthcare employees"],"prefix":"10.1136","volume":"76","author":[{"given":"Johan H\u00f8y","family":"Jensen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens 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