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C reactive protein (CRP), serum amyloid A protein and interleukin 6 were measured in plasma immediately before and 2 or 4\u2009hours after the exposures. Symptoms were rated from 0 to 100\u2009mm in Visual Analogue Scales and covered 10 questions whereof four related to irritation: discomfort in the eyes, nose and throat and dyspnoea. The effect measurements included blink frequency by electromyography, nasal swelling by acoustic rhinometry and lung function by spirometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Logistic quantile regression analyses revealed no significant associations except a negative relation between ratings of irritation and CRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results suggest a down-regulation of CRP after short-term exposure to low levels of vapours of irritating chemicals. This response might be mediated by the cholinergic anti-inflammatory pathway and further studies are recommended in order to refute or confirm this hypothesis.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oemed-2018-105537","type":"journal-article","created":{"date-parts":[[2019,3,9]],"date-time":"2019-03-09T22:15:22Z","timestamp":1552169722000},"page":"482-487","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Down-regulation of the inflammatory response after short-term exposure to low levels of chemical vapours"],"prefix":"10.1136","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2217-3394","authenticated-orcid":false,"given":"Lena","family":"Ernstg\u00e5rd","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matteo","family":"Bottai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Johanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bengt","family":"Sj\u00f6gren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,3,9]]},"reference":[{"key":"2020050723133495000_76.7.482.1","doi-asserted-by":"crossref","unstructured":"Schenk L , Johanson G . 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