{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T06:55:32Z","timestamp":1790492132580,"version":"4.1.0"},"reference-count":35,"publisher":"BMJ","issue":"5","funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Labour"},{"DOI":"10.13039\/100007391","name":"Association pour la Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007391","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Health"},{"DOI":"10.13039\/501100009571","name":"French Institute for Public Health Surveillance","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009571","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]},{"name":"French Agency for Food, Environmental and Occupational Health and Safety"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the association between occupational exposure to welding and the risk of head and neck cancer in a large French population-based case-control study, the <jats:bold>I<\/jats:bold>nvestigation of occupational and environmental <jats:bold>CA<\/jats:bold>uses of <jats:bold>RE<\/jats:bold>spiratory cancers study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Analyses were restricted to men (2703 controls and 1588 cases of squamous-cell carcinoma of the oral cavity, oropharynx, hypopharynx and larynx). Welding activity and potential confounders were assessed by detailed questionnaires. ORs and CIs (95%\u2009CI) were estimated by unconditional logistic regression, adjusted for age, area of residence, tobacco smoking, alcohol consumption and occupational exposure to asbestos.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Welding was associated with an increased risk of head and neck cancer overall (OR=1.31, 95%\u2009CI 1.03 to 1.67). The association was strongest for laryngeal cancer (OR=1.66, 95%\u2009CI 1.15 to 2.38) and the risk increased with the cumulative duration (p-trend &lt;0.01) and the weighted duration (p-trend &lt;0.01) of welding. A cumulative duration and a weighted duration of welding of more than 10 years were also associated with a significantly increased risk of oral cancer (OR=1.82, 95%\u2009CI 1.09 to 3.04; OR=2.10, 95%\u2009CI 0.99 to 4.45, respectively). A long duration of arc welding was associated with laryngeal cancer, whereas a long duration of spot welding was associated with oral cancer. Welding was not associated with the risk of oropharyngeal and hypopharyngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that welding and several welding-related tasks increase the risk of laryngeal cancer and to a lesser extent oral cancer.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oemed-2019-106080","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T22:16:54Z","timestamp":1579558614000},"page":"293-300","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Welding and the risk of head and neck cancer: the ICARE study"],"prefix":"10.1136","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3195-8348","authenticated-orcid":false,"given":"Christine","family":"Barul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9252-2612","authenticated-orcid":false,"given":"Mireille","family":"Matrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aviane","family":"Auguste","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Dugas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loredana","family":"Rado\u00ef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwenn","family":"Menvielle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00eblle","family":"F\u00e9votte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Val\u00e9rie","family":"Guizard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"St\u00fccker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1708-4584","authenticated-orcid":false,"given":"Dani\u00e8le","family":"Luce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,1,20]]},"reference":[{"key":"2020060312450582000_77.5.293.1","unstructured":"IARC Working group on the evaluation of carcinogenic risks to humans, International agency for research on cancer. welding, molybdenum trioxide, and indium tin oxide, 2018. 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