{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T13:02:19Z","timestamp":1793278939628,"version":"4.5.0"},"reference-count":24,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2020,1,11]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Trichloroethylene (TCE) -induced hypersensitivity syndrome (TIHS) is a potentially life-threatening disease. Several genetic susceptibility biomarkers have been found to be associated with TIHS, and this systematic prospective study has been conducted to evaluate the utility of these genetic susceptibility biomarkers in preventing the disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The newly hired TCE-exposed workers were recruited from March 2009 to October 2010. <jats:italic>HLA-B*13:01<\/jats:italic> genotyping and 3-month follow-up procedure were conducted. All workers were monitored for adverse reaction by telephone interview every week. The workers with early symptoms of TIHS were asked to go to the hospital immediately for further examination, diagnosis and treatment. The medical expense record data of patients with TIHS were collected for cost-effectiveness analysis in 2018.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 1651 workers, 158 (9.57%) were found to carry the <jats:italic>HLA-B*13:01<\/jats:italic> allele and 16 (0.97%) were diagnosed with TIHS. <jats:italic>HLA-B*13:01<\/jats:italic> allele was significantly associated with an increased TIHS risk (relative risk=28.4, 95% CI 9.2 to 86.8). As a risk predictor of TIHS, <jats:italic>HLA-B*13:01<\/jats:italic> testing had a sensitivity of 75%, a specificity of 91.1% and an area under curve of 0.83 (95% CI 0.705 to 0.955), the positive and negative predictive values were 7.6% and 99.7%, respectively. The incidence of TIHS was significantly decreased in <jats:italic>HLA-B*13:01<\/jats:italic> non-carriers (0.27%) compared with all workers (0.97%, p=0.014). Cost-effectiveness analysis showed that <jats:italic>HLA-B*13:01<\/jats:italic> screening could produce an economic saving of $4604 per TIHS avoided.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Prospective <jats:italic>HLA-B*13:01<\/jats:italic> screening may significantly reduce the incidence of TIHS and could be a cost effective option for preventing the disease in TCE-exposed workers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/oemed-2019-106171","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T17:15:50Z","timestamp":1580922950000},"page":"201-206","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Utility evaluation of <i>HLA-B*13:01<\/i> screening in preventing trichloroethylene-induced hypersensitivity syndrome in a prospective cohort study"],"prefix":"10.1136","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9209-8724","authenticated-orcid":false,"given":"Yufei","family":"Dai","sequence":"first","affiliation":[{"name":"Key Laboratory, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Occupational Hazards assessment, Hospital for Occupational Diseases Control of Shenzhen, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Toxicology, Shandong Academy of Occupational Health and Occupational Medicine, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Dong","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"},{"name":"Department of Nutrition and Food Hygiene, Center for Disease Control and Prevention of Yunnan Province, Kunming, Yunnan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Niu","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Occupational Hazards assessment, Hospital for Occupational Diseases Control of Shenzhen, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Bin","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yi","sequence":"additional","affiliation":[{"name":"Department of Occupational Hazards assessment, Hospital for Occupational Diseases Control of Shenzhen, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingping","family":"Xiang","sequence":"additional","affiliation":[{"name":"Department of Occupational Hazards assessment, Hospital for Occupational Diseases Control of Shenzhen, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huawei","family":"Duan","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiping","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Occupational Hazards assessment, Hospital for Occupational Diseases Control of Shenzhen, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Sha","sequence":"additional","affiliation":[{"name":"Department of Occupational Hazards assessment, Hospital for Occupational Diseases Control of Shenzhen, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meili","family":"Shen","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Ye","sequence":"additional","affiliation":[{"name":"Key Laboratory, National Institute of Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqing","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Occupational Hazards assessment, Hospital for Occupational Diseases Control of Shenzhen, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zheng","sequence":"additional","affiliation":[{"name":"School of Public Health, Qingdao University, Qingdao, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"2025081304063408000_77.3.201.1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl149"},{"key":"2025081304063408000_77.3.201.2","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1080\/08923973.2017.1364262","article-title":"Toxicological effects of trichloroethylene exposure on immune disorders","volume":"39","author":"Ordaz","year":"2017","journal-title":"Immunopharmacol Immunotoxicol"},{"key":"2025081304063408000_77.3.201.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-006-0147-y"},{"key":"2025081304063408000_77.3.201.4","doi-asserted-by":"publisher","DOI":"10.1539\/joh.48.417"},{"key":"2025081304063408000_77.3.201.5","doi-asserted-by":"publisher","DOI":"10.1539\/joh.45.8"},{"key":"2025081304063408000_77.3.201.6","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1159\/000290775","article-title":"Occupational trichloroethylene hypersensitivity syndrome with human herpesvirus-6 and cytomegalovirus reactivation","volume":"221","author":"Watanabe","year":"2010","journal-title":"Dermatology"},{"key":"2025081304063408000_77.3.201.7","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.jdermsci.2013.07.003","article-title":"Occupational trichloroethylene hypersensitivity syndrome: human herpesvirus 6 reactivation and rash phenotypes","volume":"72","author":"Kamijima","year":"2013","journal-title":"J Dermatol Sci"},{"key":"2025081304063408000_77.3.201.8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2010.01176.x"},{"key":"2025081304063408000_77.3.201.9","doi-asserted-by":"publisher","DOI":"10.1539\/joh.L8013"},{"key":"2025081304063408000_77.3.201.10","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10325"},{"key":"2025081304063408000_77.3.201.11","doi-asserted-by":"crossref","DOI":"10.1038\/srep12169","article-title":"Performance of genetic risk factors in prediction of trichloroethylene induced hypersensitivity syndrome","volume":"5","author":"Dai","year":"2015","journal-title":"Sci Rep"},{"key":"2025081304063408000_77.3.201.12","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2486\/indhealth.47.479","article-title":"Effects of genetic polymorphisms of N-acetyltransferase on trichloroethylene-induced hypersensitivity dermatitis among exposed workers","volume":"47","author":"Dai","year":"2009","journal-title":"Ind Health"},{"key":"2025081304063408000_77.3.201.13","doi-asserted-by":"publisher","DOI":"10.1080\/13547500400026920"},{"key":"2025081304063408000_77.3.201.14","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/tan.12114","article-title":"Peptide-Binding motifs and characteristics for HLA -B*13:01 molecule","volume":"81","author":"Zhang","year":"2013","journal-title":"Tissue Antigens"},{"key":"2025081304063408000_77.3.201.15","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1016\/S0140-6736(88)92178-2","article-title":"Simple non-invasive method to obtain DNA for gene analysis","volume":"1","author":"Lench","year":"1988","journal-title":"Lancet"},{"key":"2025081304063408000_77.3.201.16","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq1128"},{"key":"2025081304063408000_77.3.201.17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/j.1399-0039.2005.00526.x","article-title":"HLa-A, HLA-B, and HLA-DRB1 alleles and haplotypes in Naxi and Han populations in southwestern China (Yunnan Province)","volume":"67","author":"Shi","year":"2006","journal-title":"Tissue Antigens"},{"key":"2025081304063408000_77.3.201.18","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1399-0039.2006.00529.x","article-title":"HLA-A, -B, and -DRB1 polymorphism defined by sequence-based typing of the Han population in northern China","volume":"67","author":"Yang","year":"2006","journal-title":"Tissue Antigens"},{"key":"2025081304063408000_77.3.201.19","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1009717"},{"key":"2025081304063408000_77.3.201.20","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1001\/jamaneurol.2018.0278","article-title":"Association of HLA-A*31:01 screening with the incidence of carbamazepine-induced cutaneous adverse reactions in a Japanese population","volume":"75","author":"Mushiroda","year":"2018","journal-title":"JAMA Neurol"},{"key":"2025081304063408000_77.3.201.21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0706135"},{"key":"2025081304063408000_77.3.201.22","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.h4848","article-title":"Use of HLA-B*58:01 genotyping to prevent allopurinol induced severe cutaneous adverse reactions in Taiwan: national prospective cohort study","volume":"351","author":"Ko","year":"2015","journal-title":"BMJ"},{"key":"2025081304063408000_77.3.201.23","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/jamadermatol.2018.5360","article-title":"Evaluation of prospective HLA-B*13:01 screening to prevent dapsone hypersensitivity syndrome in patients with leprosy","volume":"155","author":"Liu","year":"2019","journal-title":"JAMA Dermatol"},{"key":"2025081304063408000_77.3.201.24","doi-asserted-by":"crossref","first-page":"300","DOI":"10.2486\/indhealth.2017-0202","article-title":"Exposure reconstruction of trichloroethylene among patients with occupational trichloroethylene hypersensitivity syndrome","volume":"56","author":"Nakajima","year":"2018","journal-title":"Ind Health"}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oemed-2019-106171","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,13]],"date-time":"2025-08-13T11:07:37Z","timestamp":1755083257000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oemed-2019-106171"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,5]]},"references-count":24,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,2,13]]},"published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1136\/oemed-2019-106171"],"URL":"https:\/\/doi.org\/10.1136\/oemed-2019-106171","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"value":"1351-0711","type":"print"},{"value":"1470-7926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,5]]}}}