{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:21:13Z","timestamp":1792023673305,"version":"4.4.0"},"reference-count":39,"publisher":"BMJ","issue":"3","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2020,9,26]]},"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore associations between occupational exposure to four specific organic solvents, respectively, and female breast cancer, including subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the Danish Cancer Registry, we identified 38\u2009375 women under age 70 years with primary breast cancer. Five randomly selected breast-cancer-free controls per case matched on year of birth were retrieved from the Danish Civil Registration System . A nationwide pension fund was used to retrieve full employment history, and exposure to 1,1,1-trichloroethane, trichloroethylene (TCE), benzene and toluene was assessed using a job exposure matrix. ORs were estimated using conditional logistic regression with adjustment for reproductive factors and socioeconomic status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall results indicated no noteworthy associations between the specific organic solvents and breast cancer before and after age 50 years, except for a small increased risk after age 50 in women exposed to TCE (OR=1.15, 95%\u2009CI: 0.97\u20131.36). After age 50 years, exposure to TCE was associated with a small increased risk in women with over 20 years of latency (OR=1.26, 95%\u2009CI: 1.02\u20131.56). Further, an increased risk of oestrogen receptor positive (ER+) tumours was also observed (OR=1.21, 95%\u2009CI: 1.01\u20131.47), and high cumulative exposure and longer latency also increased the risk of this subtype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study provides limited evidence supporting the association between occupational exposure to each of the four organic solvents and breast cancer. The risk of ER+ breast tumours after age 50\u2009years may be increased in women with TCE exposure, and this possible association therefore needs further attention in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oemed-2020-106865","type":"journal-article","created":{"date-parts":[[2020,10,22]],"date-time":"2020-10-22T21:20:59Z","timestamp":1603401659000},"page":"192-198","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Occupational exposure to specific organic solvents and risk of subtypes of breast cancer in a large population of Danish women, 1964\u20132016"],"prefix":"10.1136","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5158-696X","authenticated-orcid":false,"given":"Julie Elbaek","family":"Pedersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrine","family":"Strandberg-Larsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Andersson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johnni","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2020,10,22]]},"reference":[{"key":"2024110805001768000_78.3.192.1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.29210"},{"key":"2024110805001768000_78.3.192.2","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.10270"},{"key":"2024110805001768000_78.3.192.3","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/0024-6301(83)90158-9","article-title":"Working women in the European community\u2014The future prospect","volume":"16","author":"Davidson","year":"1983","journal-title":"Long Range Plann"},{"key":"2024110805001768000_78.3.192.4","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199707)32:1<1::AID-AJIM1>3.0.CO;2-3"},{"key":"2024110805001768000_78.3.192.5","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2005.022400"},{"key":"2024110805001768000_78.3.192.6","unstructured":"Iarc . 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