{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:28:18Z","timestamp":1790803698073,"version":"4.1.0"},"reference-count":55,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Adverse occupational exposures can accelerate age-related lung function decline. Some longitudinal population-based studies have investigated this association. This study aims to examine this association using findings reported by longitudinal population-based studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ovid Medline, PubMed, Embase, and Web of Science were searched using keywords and text words related to occupational exposures and lung function and 12 longitudinal population-based studies were identified using predefined inclusion criteria. The quality of the studies was assessed using the Newcastle-Ottawa Scale. Lung function decline was defined as annual loss of forced expiratory volume in 1\u2009s (FEV<jats:sub>1<\/jats:sub>), forced vital capacity (FVC) or the ratio (FEV<jats:sub>1<\/jats:sub>\/FVC). Fixed and random-effects meta-analyses were conducted to calculate pooled estimates for ever and cumulative exposures. Heterogeneity was assessed using the I<jats:sup>2<\/jats:sup>test, and publication bias was evaluated using funnel plots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ever exposures to gases\/fumes, vapours, gases, dusts, fumes (VGDF) and aromatic solvents were significantly associated with FEV<jats:sub>1<\/jats:sub>decline in meta-analyses. Cumulative exposures for these three occupational agents observed a similar trend of FEV<jats:sub>1<\/jats:sub>decline. Ever exposures to fungicides and cumulative exposures to biological dust, fungicides and insecticides were associated with FEV<jats:sub>1<\/jats:sub>decline in fixed-effect models only. No statistically significant association was observed between mineral dust, herbicides and metals and FEV<jats:sub>1<\/jats:sub>decline in meta-analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Pooled estimates from the longitudinal population-based studies have provided evidence that occupational exposures are associated with FEV<jats:sub>1<\/jats:sub>decline. Specific exposure control and respiratory health surveillance are required to protect the lung health of the workers.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oemed-2022-108237","type":"journal-article","created":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T12:33:12Z","timestamp":1667219592000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":24,"title":["Ever and cumulative occupational exposure and lung function decline in longitudinal population-based studies: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4172-3438","authenticated-orcid":false,"given":"Golam","family":"Rabbani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naima","family":"Nimmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geza P","family":"Benke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shyamali C","family":"Dharmage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinh","family":"Bui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4739-2817","authenticated-orcid":false,"given":"Malcolm R","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Abramson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0783-8848","authenticated-orcid":false,"given":"Sheikh M","family":"Alif","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,10,24]]},"reference":[{"key":"2023100119251030000_80.1.51.1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2018-212267"},{"key":"2023100119251030000_80.1.51.2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu053"},{"key":"2023100119251030000_80.1.51.3","doi-asserted-by":"publisher","DOI":"10.1513\/pats.200404-032MS"},{"key":"2023100119251030000_80.1.51.4","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-2192"},{"key":"2023100119251030000_80.1.51.5","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.163.4.2006063"},{"key":"2023100119251030000_80.1.51.6","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00007711"},{"key":"2023100119251030000_80.1.51.7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.13-1429"},{"key":"2023100119251030000_80.1.51.8","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2013-101639"},{"key":"2023100119251030000_80.1.51.9","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2004.035170"},{"key":"2023100119251030000_80.1.51.10","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201110-1917OC"},{"key":"2023100119251030000_80.1.51.11","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2016.1190274"},{"key":"2023100119251030000_80.1.51.12","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2016-103963"},{"key":"2023100119251030000_80.1.51.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.puhe.2019.05.024"},{"key":"2023100119251030000_80.1.51.14","doi-asserted-by":"crossref","DOI":"10.1136\/thoraxjnl-2020-216523","article-title":"Lifetime occupational exposures and chronic obstructive pulmonary disease risk in the UK Biobank cohort","author":"De Matteis","year":"2022","journal-title":"Thorax"},{"key":"2023100119251030000_80.1.51.15","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2013-101796"},{"key":"2023100119251030000_80.1.51.16","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"2023100119251030000_80.1.51.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2018.07.015"},{"key":"2023100119251030000_80.1.51.18","unstructured":"Wells G , Shea B , O'Connell D . 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