{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:03:14Z","timestamp":1791241394369,"version":"4.1.0"},"reference-count":46,"publisher":"BMJ","issue":"8","funder":[{"name":"General Research Fund of University Grant Committee of Hong Kong","award":["14603019"],"award-info":[{"award-number":["14603019"]}]},{"DOI":"10.13039\/501100021171","name":"Guangdong Basic and Applied Basic Research Foundation","doi-asserted-by":"crossref","award":["2019A1515011697"],"award-info":[{"award-number":["2019A1515011697"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Exercise may increase the inhaled amount of air pollutants and exacerbate the adverse health effects. We investigated the combined effects of chronic exposure to fine particulate matter with an aerodynamic diameter less than 2.5 \u00b5m (PM<jats:sub>2.5<\/jats:sub>) and habitual exercise on C reactive protein (CRP), a sensitive marker of inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We selected 40 209 Taiwanese adults who joined a standard medical screening programme between 2001 and 2016. The PM<jats:sub>2.5<\/jats:sub>exposure was estimated at each participant\u2019s address using a satellite-based spatiotemporal model. Information on habitual exercise was collected using a standard self-administered questionnaire. Mixed-effects linear regression models were used to investigate the associations of CRP with PM<jats:sub>2.5<\/jats:sub>and exercise. An interaction term of PM<jats:sub>2.5<\/jats:sub>and exercise was introduced in the models to test the modifying effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A greater amount of habitual exercise was associated with a decreased level of CRP, while a higher concentration of PM<jats:sub>2.5<\/jats:sub>exposure was associated with an increased level of CRP. The inverse associations of habitual exercise with CRP were not modified by chronic exposure to PM<jats:sub>2.5<\/jats:sub>. The participants in the group with a low level of exercise and a high level of PM<jats:sub>2.5<\/jats:sub>exposure exhibited a 19.1% higher level of CRP than those in the group with a high level of exercise and a low level of PM<jats:sub>2.5<\/jats:sub>exposure (95% CI: 13.7% to 24.8%; p&lt;0.001). The longitudinal and sensitivity analyses yielded similar results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Increased levels of exercise and reduced exposure levels of PM<jats:sub>2.5<\/jats:sub>are associated with a lower CRP level. Habitual exercise reduces CRP level regardless of the levels of chronic PM<jats:sub>2.5<\/jats:sub>exposure. Our results support that habitual exercise is a safe approach for reducing systemic inflammation to improve cardiovascular health even for people residing in relatively polluted areas.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oemed-2022-108328","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T17:21:52Z","timestamp":1656004912000},"page":"557-565","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Habitual exercise, chronic exposure to fine particulate matter and high-sensitivity C reactive protein in Asian adults"],"prefix":"10.1136","volume":"79","author":[{"given":"Yi Qian","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin Heng Teresa","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cui","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ly-yun","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yacong","family":"Bo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changqing","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengli","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis K.H.","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"Tam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2645-0128","authenticated-orcid":false,"given":"Xiang Qian","family":"Lao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,6,23]]},"reference":[{"key":"2023100119350502000_79.8.557.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2020.11.010"},{"key":"2023100119350502000_79.8.557.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000052939.59093.45"},{"key":"2023100119350502000_79.8.557.3","unstructured":"US. 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