{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T09:53:43Z","timestamp":1793094823143,"version":"4.5.0"},"reference-count":40,"publisher":"BMJ","issue":"10","funder":[{"name":"the French Agency for Food, Environmental and Occupational Health & Safety","award":["ANSES Grant 07-CRD-51 and EST 2006\/1\/43 and EST 20"],"award-info":[{"award-number":["ANSES Grant 07-CRD-51 and EST 2006\/1\/43 and EST 20"]}]},{"name":"the French National Health Insurance","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"name":"the French Ministry of Labour and Social Relations","award":["N.A"],"award-info":[{"award-number":["N.A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Occupational asbestos exposure is associated with pleural plaques (PP), a benign disease often seen as a marker of past exposure to asbestos and lung cancer. The association between these two diseases has not been formally proved, the aim of this study was to evaluate this association in the asbestos-related disease cohort (ARDCO) cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>ARDCO is a French multicentric cohort including workers formerly occupationally exposed to asbestos from 2003 to 2005. CT scan was performed to diagnose PP with double reading and lung cancer (incidence and mortality) was followed through health insurance data and death certificates. Cox models were used to estimate the association between PP and lung cancer adjusting for occupational asbestos exposure (represented by cumulative exposure index, time since first exposure and time since last exposure) and smoking status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 176 cases (of 5050 subjects) and 88 deaths (of 4938 subjects) of lung cancer were recorded. Smoking status was identified as an effect modifier. Lung cancer incidence and mortality were significantly associated with PP only in non-smokers, respectively, HR=3.13 (95% CI 1.04 to 9.35) and HR=16.83 (95% CI 1.87 to 151.24) after adjustment for age, occupational asbestos exposure and smoking status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>ARDCO study was the first to study this association considering equal asbestos exposure, and more specifically, our study is the first to test smoking as an effect modifier, so comparison with scientific literature is difficult. Our results seem to consolidate the hypothesis that PP may be an independent risk factor for lung cancer but they must be interpreted with caution.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/oemed-2022-108337","type":"journal-article","created":{"date-parts":[[2022,8,3]],"date-time":"2022-08-03T13:26:22Z","timestamp":1659533182000},"page":"706-712","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Pleural plaques and risk of lung cancer in workers formerly occupationally exposed to asbestos: extension of follow-up"],"prefix":"10.1136","volume":"79","author":[{"given":"Justine","family":"Gallet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Laurent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Paris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9138-5265","authenticated-orcid":false,"given":"B\u00e9n\u00e9dicte","family":"Clin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Gislard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Thaon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soizick","family":"Chammings","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine","family":"Gramond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Ogier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilbert","family":"Ferretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Andujar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Brochard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5594-5405","authenticated-orcid":false,"given":"Fleur","family":"Delva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Claude","family":"Pairon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Lacourt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,8,3]]},"reference":[{"key":"2023050500501017000_79.10.706.1","unstructured":"IARC Working Group on the Evaluation of Carcinogenic Risk to Humans . Arsenic, metals, fibres, and dusts. Lyon (FR): International Agency for Research on Cancer, 2012. https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK304375\/"},{"key":"2023050500501017000_79.10.706.2","first-page":"1187","article-title":"[Consensus development conference for the elaboration of a clinical medical surveillance strategy for people exposed to asbestos. Paris, France, 15 January 1999]","volume":"16","year":"1999","journal-title":"Rev Mal Respir"},{"key":"2023050500501017000_79.10.706.3","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200310-1436ST"},{"key":"2023050500501017000_79.10.706.4","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.rmr.2012.02.012","article-title":"[The different pleuro-pulmonary pathologies related to asbestos: definitions, epidemiology and evolution]","volume":"29","author":"Ameille","year":"2012","journal-title":"Rev Mal Respir"},{"key":"2023050500501017000_79.10.706.5","first-page":"e17","article-title":"[Post-professional follow-up after asbestos exposure]","volume":"27","year":"2010","journal-title":"Rev Mal Respir"},{"key":"2023050500501017000_79.10.706.6","unstructured":"Institut national de la sant\u00e9 et de la recherche m . Effets sur La sant\u00e9 des principaux types d'exposition l'amiante. Rapport. Paris: Les \u00e9ditions Inserm, 1997: 434 p.."},{"key":"2023050500501017000_79.10.706.7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.3.1103"},{"key":"2023050500501017000_79.10.706.8","doi-asserted-by":"publisher","DOI":"10.1186\/1476-069X-7-30"},{"key":"2023050500501017000_79.10.706.9","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00094008"},{"key":"2023050500501017000_79.10.706.10","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/21.6.1180"},{"key":"2023050500501017000_79.10.706.11","first-page":"461","article-title":"Natural history of pleural thickening after exposure to crocidolite","volume":"46","author":"de Klerk","year":"1989","journal-title":"Br J Ind Med"},{"key":"2023050500501017000_79.10.706.12","doi-asserted-by":"publisher","DOI":"10.1378\/chest.99.1.191"},{"key":"2023050500501017000_79.10.706.13","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0761-8425(08)71517-1","article-title":"[Occupational respiratory cancers]","volume":"25","author":"Pairon","year":"2008","journal-title":"Rev Mal Respir"},{"key":"2023050500501017000_79.10.706.14","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijheh.2018.07.015","article-title":"Cancers in France in 2015 attributable to occupational exposures","volume":"222","author":"Marant Micallef","year":"2019","journal-title":"Int J Hyg Environ Health"},{"key":"2023050500501017000_79.10.706.15","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3109\/10408444.2014.902423","article-title":"A review and critique of U.S. EPA's risk assessments for asbestos","volume":"44","author":"Moolgavkar","year":"2014","journal-title":"Crit Rev Toxicol"},{"key":"2023050500501017000_79.10.706.16","doi-asserted-by":"publisher","DOI":"10.1378\/chest.115.2.536"},{"key":"2023050500501017000_79.10.706.17","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.186"},{"key":"2023050500501017000_79.10.706.18","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1136\/oem.2005.020834","article-title":"The effect of asbestosis on lung cancer risk beyond the dose related effect of asbestos alone","volume":"62","author":"Reid","year":"2005","journal-title":"Occup Environ Med"},{"key":"2023050500501017000_79.10.706.19","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-1345"},{"key":"2023050500501017000_79.10.706.20","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201406-1074OC"},{"key":"2023050500501017000_79.10.706.21","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1164\/rccm.201901-0096OC","article-title":"Pleural plaques and the risk of lung cancer in asbestos-exposed subjects","volume":"201","author":"Brims","year":"2020","journal-title":"Am J Respir Crit Care Med"},{"key":"2023050500501017000_79.10.706.22","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djs513"},{"key":"2023050500501017000_79.10.706.23","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200812-1815OC"},{"key":"2023050500501017000_79.10.706.24","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2014-102336"},{"key":"2023050500501017000_79.10.706.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.respe.2009.04.011"},{"key":"2023050500501017000_79.10.706.26","doi-asserted-by":"publisher","DOI":"10.1002\/sim.4067"},{"key":"2023050500501017000_79.10.706.27","doi-asserted-by":"publisher","DOI":"10.1002\/mpr.329"},{"key":"2023050500501017000_79.10.706.28","doi-asserted-by":"publisher","DOI":"10.1080\/00313020400010955"},{"key":"2023050500501017000_79.10.706.29","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/45.5.341"},{"key":"2023050500501017000_79.10.706.30","first-page":"3305","article-title":"Pulmonary expression of glutathione S-transferase M3 in lung cancer patients: association with GSTM1 polymorphism, smoking, and asbestos exposure","volume":"55","author":"Anttila","year":"1995","journal-title":"Cancer Res"},{"key":"2023050500501017000_79.10.706.31","doi-asserted-by":"publisher","DOI":"10.1136\/oem.58.3.145"},{"key":"2023050500501017000_79.10.706.32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135798","article-title":"Additive synergism between asbestos and smoking in lung cancer risk: a systematic review and meta-analysis","volume":"10","author":"Ngamwong","year":"2015","journal-title":"PLoS One"},{"key":"2023050500501017000_79.10.706.33","doi-asserted-by":"publisher","DOI":"10.1378\/chest.105.1.144"},{"key":"2023050500501017000_79.10.706.34","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008845332422"},{"key":"2023050500501017000_79.10.706.35","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwi034"},{"key":"2023050500501017000_79.10.706.36","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2009-0206TR"},{"key":"2023050500501017000_79.10.706.37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S0272-5231(21)00729-2","article-title":"Computed tomography of asbestos-related pulmonary parenchymal and pleural diseases","volume":"12","author":"Aberle","year":"1991","journal-title":"Clin Chest Med"},{"key":"2023050500501017000_79.10.706.38","first-page":"641","article-title":"Pleural plaques and asbestos-associated malignancy","volume":"29","author":"Harber","year":"1987","journal-title":"J Occup Med"},{"key":"2023050500501017000_79.10.706.39","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S0761-8425(09)74046-X","article-title":"[Asbestos-related cancer risk in the presence of asbestosis or pleural plaques]","volume":"26","author":"Ameille","year":"2009","journal-title":"Rev Mal Respir"},{"key":"2023050500501017000_79.10.706.40","first-page":"54","article-title":"Cancer surveillance in France: current tools and perspectives","volume":"5-6","author":"Danzon","year":"2012","journal-title":"Bulletin \u00e9pid\u00e9miologique hebdomadaire"}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oemed-2022-108337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T03:51:31Z","timestamp":1683258691000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oemed-2022-108337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,3]]},"references-count":40,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2022,9,14]]},"published-print":{"date-parts":[[2022,10]]}},"alternative-id":["10.1136\/oemed-2022-108337"],"URL":"https:\/\/doi.org\/10.1136\/oemed-2022-108337","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"value":"1351-0711","type":"print"},{"value":"1470-7926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,3]]}}}