{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:34:47Z","timestamp":1792373687757,"version":"4.4.0"},"reference-count":44,"publisher":"BMJ","issue":"3","license":[{"start":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T00:00:00Z","timestamp":1673481600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/N013468\/1"],"award-info":[{"award-number":["MR\/N013468\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016060","name":"Stichting De Cock-Hadders","doi-asserted-by":"publisher","award":["2022-61"],"award-info":[{"award-number":["2022-61"]}],"id":[{"id":"10.13039\/100016060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Dupuytren\u2019s disease (DD) is a fibroproliferative disorder of the hands, characterised by the development of fibrous nodules and cords that may cause disabling contractures of the fingers. The role of manual work exposure in the aetiology of DD is controversial. We investigated whether current occupational exposure to manual work is associated with DD, and if there is a dose\u2013response relationship.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this population-based cohort analysis, we used data from the UK Biobank cohort. Our primary outcome was the presence of DD. The exposure of interest was manual work, measured for each participant in two different ways to allow two independent analyses to be undertaken: (1) the current manual work status of the occupation at the time of recruitment, and (2) a cumulative manual work exposure score, calculated based on the occupational history. We performed propensity score matching and applied a logistic regression model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 196\u2009265 participants for the current manual work analysis, and 96\u2009563 participants for the dose\u2013response analysis. Participants whose current occupation usually\/always involved manual work were more often affected with DD than participants whose occupation sometimes\/never involved manual work (OR 1.29, 95%\u2009CI 1.12 to 1.49, p&lt;0.001). There was a positive dose\u2013response relationship between cumulative manual work exposure score and DD. Each increment in cumulative work exposure score increased the odds by 17% (OR 1.17, 95%\u2009CI 1.08 to 1.27, p&lt;0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Manual work exposure is a risk factor for DD, with a clear dose\u2013response relationship. Physicians treating patients should recognise DD as a work-related disorder and inform patients accordingly.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oemed-2022-108670","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T18:25:03Z","timestamp":1673547903000},"page":"137-145","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Dupuytren\u2019s disease is a work-related disorder: results of a population-based cohort study"],"prefix":"10.1136","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7893-5661","authenticated-orcid":false,"given":"Bente A.","family":"van den Berge","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Wiberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M. N.","family":"Werker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieuwke C.","family":"Broekstra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2780-7173","authenticated-orcid":false,"given":"Dominic","family":"Furniss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,1,12]]},"reference":[{"key":"2023022202250860000_80.3.137.1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000438455.37604.0f"},{"key":"2023022202250860000_80.3.137.2","first-page":"246","article-title":"The early history of contracture of the palmar fascia. Part 1: the origin of the disease: the curse of the MacCrimmons: the hand of benediction: cline's contracture","volume":"13","author":"Elliot","year":"1988","journal-title":"J Hand Surg Br"},{"key":"2023022202250860000_80.3.137.3","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/PRS.0000000000007146","article-title":"Nongenetic factors associated with Dupuytren's disease: a systematic review","volume":"146","author":"Alser","year":"2020","journal-title":"Plast Reconstr Surg"},{"key":"2023022202250860000_80.3.137.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1101029"},{"key":"2023022202250860000_80.3.137.5","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2019-105912"},{"key":"2023022202250860000_80.3.137.6","doi-asserted-by":"crossref","unstructured":"Descatha A , Carton M , Mediouni Z , et al . Association among work exposure, alcohol intake, smoking and Dupuytren\u2019s disease in a large cohort study (GAZEL). BMJ Open 2014;4:4214.doi:10.1136\/bmjopen-2013-004214","DOI":"10.1136\/bmjopen-2013-004214"},{"key":"2023022202250860000_80.3.137.7","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1002\/ajim.22736","article-title":"Dupuytren's contracture and handwork: a case-control study","volume":"60","author":"Haines","year":"2017","journal-title":"Am J Ind Med"},{"key":"2023022202250860000_80.3.137.8","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jhsb.2003.08.012","article-title":"The role of manual occupation in the aetiology of Dupuytren's disease in men in England and Wales","volume":"29","author":"Khan","year":"2004","journal-title":"J Hand Surg Br"},{"key":"2023022202250860000_80.3.137.9","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/occmed\/kqaa211","article-title":"Is Dupuytren's disease an occupational illness?","volume":"71","author":"Mur\u00ednov\u00e1","year":"2021","journal-title":"Occup Med"},{"key":"2023022202250860000_80.3.137.10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2474-12-96","article-title":"Should we consider Dupuytren\u2019s contracture as work-related? A review and meta-analysis of an old debate","volume":"12","author":"Descatha","year":"2011","journal-title":"BMC Musculoskelet Disord"},{"key":"2023022202250860000_80.3.137.11","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1001779"},{"key":"2023022202250860000_80.3.137.12","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1038\/s41431-019-0483-5","article-title":"Ethnic differences in prevalence of Dupuytren disease can partly be explained by known genetic risk variants","volume":"27","author":"Riesmeijer","year":"2019","journal-title":"Eur J Hum Genet"},{"key":"2023022202250860000_80.3.137.13","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-09078-0"},{"key":"2023022202250860000_80.3.137.14","unstructured":"United Kingdom Office for National Statistics . SOC 2000: previous version of the standard occupational classification, 2016. United Kingdom Office for National Statistics [Internet]. Available: https:\/\/www.ons.gov.uk\/methodology\/classificationsandstandards\/standardoccupationalclassificationsoc\/socarchive [Accessed 03 Aug 2022]."},{"key":"2023022202250860000_80.3.137.15","unstructured":"National Center for O*NET Development . O*NET 16.0 database, 2011. Available: https:\/\/www.onetcenter.org\/ [Accessed 03 Aug 2022]."},{"key":"2023022202250860000_80.3.137.16","unstructured":"United States Bureau of Labor Statistics . 2010 standard occupational classification system, 2018. Available: https:\/\/www.bls.gov\/soc\/2010\/home.htm"},{"key":"2023022202250860000_80.3.137.17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1093\/occmed\/kqab173","article-title":"Physical work exposure matrix for use in the UK Biobank","volume":"72","author":"Yanik","year":"2022","journal-title":"Occup Med"},{"key":"2023022202250860000_80.3.137.18","doi-asserted-by":"crossref","first-page":"574E","DOI":"10.1097\/PRS.0000000000006551","article-title":"Dupuytren's disease predicts increased all-cause and cancer-specific mortality: analysis of a large cohort from the U.K. clinical practice research Datalink","volume":"145","author":"Kuo","year":"2020","journal-title":"Plast Reconstr Surg"},{"key":"2023022202250860000_80.3.137.19","unstructured":"Townsend P , Phillimore P , Beattie A . Beattie Alastair. Health and deprivation\u202f: inequality and the North. 211, 1988."},{"key":"2023022202250860000_80.3.137.20","doi-asserted-by":"publisher","DOI":"10.1093\/pubmed\/fdh193"},{"key":"2023022202250860000_80.3.137.21","doi-asserted-by":"crossref","first-page":"e576","DOI":"10.1016\/S2468-2667(18)30200-7","article-title":"The effect of socioeconomic deprivation on the association between an extended measurement of unhealthy lifestyle factors and health outcomes: a prospective analysis of the UK Biobank cohort","volume":"3","author":"Foster","year":"2018","journal-title":"Lancet Public Health"},{"key":"2023022202250860000_80.3.137.22","doi-asserted-by":"publisher","DOI":"10.1111\/1475-6773.12182"},{"key":"2023022202250860000_80.3.137.23","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1111\/jep.12072","article-title":"Using balance statistics to determine the optimal number of controls in matching studies","volume":"19","author":"Linden","year":"2013","journal-title":"J Eval Clin Pract"},{"key":"2023022202250860000_80.3.137.24","unstructured":"R Core Team . R: a language and environment for statistical computing. Vienna, Austria R Foundation for Statistical Computing; 2022."},{"key":"2023022202250860000_80.3.137.25","doi-asserted-by":"publisher","DOI":"10.18637\/JSS.V042.I08"},{"key":"2023022202250860000_80.3.137.26","doi-asserted-by":"publisher","DOI":"10.18637\/jss.v067.i0"},{"key":"2023022202250860000_80.3.137.27","doi-asserted-by":"crossref","unstructured":"Sedgwick P . Relative risks versus odds ratios. BMJ 2014;348:g1407.doi:10.1136\/bmj.g1407","DOI":"10.1136\/bmj.g1407"},{"key":"2023022202250860000_80.3.137.28","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.20542"},{"key":"2023022202250860000_80.3.137.29","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2013-101981"},{"key":"2023022202250860000_80.3.137.30","first-page":"384","article-title":"Dupuytren's disease: predicting factors and associated conditions. A single center questionnaire-based case-control study","volume":"5","author":"Morelli","year":"2017","journal-title":"Arch Bone Jt Surg"},{"key":"2023022202250860000_80.3.137.31","doi-asserted-by":"publisher","DOI":"10.1136\/oemed-2011-100319"},{"key":"2023022202250860000_80.3.137.32","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1987.00370060061012"},{"key":"2023022202250860000_80.3.137.33","doi-asserted-by":"crossref","DOI":"10.1097\/00000658-195411000-00007","article-title":"Dupuytren's contracture: the significance of various factors in its etiology","volume":"140","author":"Gordon","year":"1954","journal-title":"Ann Surg"},{"key":"2023022202250860000_80.3.137.34","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13889-6"},{"key":"2023022202250860000_80.3.137.35","doi-asserted-by":"crossref","first-page":"753e","DOI":"10.1097\/PRS.0000000000008420","article-title":"Factors associated with the development, progression, and outcome of Dupuytren disease treatment: a systematic review","volume":"148","author":"Geoghegan","year":"2021","journal-title":"Plast Reconstr Surg"},{"key":"2023022202250860000_80.3.137.36","first-page":"165","article-title":"Microfilament system in the microvascular endothelium of the palmar fascia affected by mechanical stress applied from outside","volume":"429","author":"Brandes","year":"1996","journal-title":"Virchows Arch"},{"key":"2023022202250860000_80.3.137.37","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.295.6610.1373"},{"key":"2023022202250860000_80.3.137.38","doi-asserted-by":"publisher","DOI":"10.1093\/annhyg\/37.3.253"},{"key":"2023022202250860000_80.3.137.39","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2016-096236"},{"key":"2023022202250860000_80.3.137.40","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5868-9-116"},{"key":"2023022202250860000_80.3.137.41","doi-asserted-by":"publisher","DOI":"10.2337\/dc20-1721"},{"key":"2023022202250860000_80.3.137.42","doi-asserted-by":"publisher","DOI":"10.1111\/dar.12104"},{"key":"2023022202250860000_80.3.137.43","doi-asserted-by":"crossref","first-page":"379","DOI":"10.3111\/13696990701646577","article-title":"Choosing propensity score matching over regression adjustment for causal inference: when, why and how it makes sense","volume":"10","author":"Baser","year":"2007","journal-title":"J Med Econ"},{"key":"2023022202250860000_80.3.137.44","doi-asserted-by":"crossref","first-page":"603","DOI":"10.2217\/cer-2020-0013","article-title":"Propensity score matching and inverse probability of treatment weighting to address confounding by indication in comparative effectiveness research of oral anticoagulants","volume":"9","author":"Allan","year":"2020","journal-title":"J Comp Eff Res"}],"container-title":["Occupational and Environmental Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/oemed-2022-108670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,2,22]],"date-time":"2023-02-22T10:27:02Z","timestamp":1677061622000},"score":1,"resource":{"primary":{"URL":"https:\/\/oem.bmj.com\/lookup\/doi\/10.1136\/oemed-2022-108670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,12]]},"references-count":44,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2,14]]},"published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1136\/oemed-2022-108670"],"URL":"https:\/\/doi.org\/10.1136\/oemed-2022-108670","relation":{},"ISSN":["1351-0711","1470-7926"],"issn-type":[{"value":"1351-0711","type":"print"},{"value":"1470-7926","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,12]]}}}