{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:37:33Z","timestamp":1793824653642,"version":"4.6.1"},"reference-count":41,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T00:00:00Z","timestamp":1718841600000},"content-version":"unspecified","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003417","name":"Deutsche Gesetzliche Unfallversicherung","doi-asserted-by":"publisher","award":["FP 271"],"award-info":[{"award-number":["FP 271"]}],"id":[{"id":"10.13039\/501100003417","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Danish Working Environment Research Fund","award":["20140016763"],"award-info":[{"award-number":["20140016763"]}]},{"name":"Danish Working Environment Research Fund","award":["34-2019-09"],"award-info":[{"award-number":["34-2019-09"]}]},{"name":"Danish Working Environment Research Fund","award":["43-2014-03"],"award-info":[{"award-number":["43-2014-03"]}]},{"name":"Danish Working Environment Research Fund","award":["47-2019-03"],"award-info":[{"award-number":["47-2019-03"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2024,4,26]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Respirable crystalline silica is a well-known cause of silicosis but may also be associated with other types of interstitial lung disease. We examined the associations between occupational exposure to respirable crystalline silica and the risk of idiopathic interstitial pneumonias, pulmonary sarcoidosis and silicosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The total Danish working population was followed 1977\u20132015. Annual individual exposure to respirable crystalline silica was estimated using a quantitative job exposure matrix. Cases were identified in the Danish National Patient Register. We conducted adjusted analyses of exposure\u2013response relations between cumulative silica exposure and other exposure metrics and idiopathic interstitial pneumonias, pulmonary sarcoidosis and silicosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean cumulative exposure was 125 \u00b5g\/m<jats:sup>3<\/jats:sup>-years among exposed workers. We observed increasing incidence rate ratios with increasing cumulative silica exposure for idiopathic interstitial pneumonias, pulmonary sarcoidosis and silicosis. For idiopathic interstitial pneumonias and pulmonary sarcoidosis, trends per 50 \u00b5g\/m<jats:sup>3<\/jats:sup>-years were 1.03 (95% CI 1.02 to 1.03) and 1.06 (95% CI 1.04 to 1.07), respectively. For silicosis, we observed the well-known exposure\u2013response relation with a trend per 50 \u00b5g\/m<jats:sup>3<\/jats:sup>-years of 1.20 (95% CI 1.17 to 1.23).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study suggests that silica inhalation may be related to pulmonary sarcoidosis and idiopathic interstitial pneumonias, though these findings may to some extent be explained by diagnostic misclassification. The observed exposure\u2013response relations for silicosis at lower cumulative exposure levels than previously reported need to be corroborated in analyses that address the limitations of this study.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oemed-2023-108964","type":"journal-article","created":{"date-parts":[[2024,6,20]],"date-time":"2024-06-20T17:26:40Z","timestamp":1718904400000},"page":"279-286","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":27,"title":["Occupational exposure to respirable crystalline silica and incident idiopathic interstitial pneumonias and pulmonary sarcoidosis: a national prospective follow-up study"],"prefix":"10.1136","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0064-4822","authenticated-orcid":false,"given":"Inge Brosb\u00f8l","family":"Iversen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper 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