{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:24:09Z","timestamp":1791473049322,"version":"4.3.4"},"reference-count":31,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"unspecified","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2024,6,15]]},"published-print":{"date-parts":[[2024,7]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>The Seveso accident (1976) caused the contamination with 2,3,7,8-tetrachlorodibenzo-para-dioxin (TCDD) in an area north of Milan, Italy. We report the results of the update of mortality and cancer incidence in the exposed population through 2013.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study cohort includes subjects living in three contaminated zones with decreasing TCDD soil concentrations (zone A, B and R) and in a surrounding uncontaminated territory (reference). Poisson models stratified\/adjusted for gender, age and period were fitted to calculate rate ratios (RRs) and 95% CIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In zone A in males, we found elevated mortality from circulatory diseases in the first decade after the accident (17 deaths, RR 2.00, 95%\u2009CI 1.24 to 3.23). In females, mortality from diabetes mellitus was increased, with a positive trend across zones. Incidence of soft tissue sarcoma was increased in males in zone R in the first decade (6 cases, RR 2.62, 95%\u2009CI 1.01 to 6.83). In females in zone B, there was an excess of non-Hodgkin\u2019s lymphoma after 30 years (6 cases, RR 2.87, 95%\u2009CI 1.14 to 7.23). Multiple myeloma was increased in the second decade in females in zone B (4 cases, RR 5.09, 95%\u2009CI 1.82 to 14.2) and in males in zone R (11 cases, RR 2.15, 95% CI 1.08 to 4.26). In males in zone R, there was a leukaemia excess after 30 years (23 cases, RR 2.02, 95%\u2009CI 1.04 to 3.93).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although with different patterns across gender, zone and time, we confirmed previous results of increased cardiovascular diseases, diabetes, soft tissue sarcoma, and lymphatic and haematopoietic cancers.<\/jats:p><\/jats:sec>","DOI":"10.1136\/oemed-2023-109167","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T17:20:14Z","timestamp":1719940814000},"page":"349-358","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Mortality and cancer incidence in a population exposed to TCDD after the Seveso, Italy, accident (1976\u20132013)"],"prefix":"10.1136","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8935-3843","authenticated-orcid":false,"given":"Dario","family":"Consonni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magda","family":"Rognoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Cavalieri d'Oro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0261-3252","authenticated-orcid":false,"given":"Angela Cecilia","family":"Pesatori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"key":"2024082000250658000_81.7.349.1","doi-asserted-by":"crossref","unstructured":"Schecter A . Dioxins and health. Including other persistent organic pollutants and endocrine disruptors. 3rd edn. Hoboken, NJ: Wiley, 2012.","DOI":"10.1002\/9781118184141"},{"key":"2024082000250658000_81.7.349.2","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1080\/15287399209531628","article-title":"Recent developments on the hazards posed by 2,3,7,8-Tetrachlorodibenzo-P-dioxin in soil: implications for setting risk-based cleanup levels at residential and industrial sites","volume":"36","author":"Paustenbach","year":"1992","journal-title":"J Toxicol Environ Health"},{"key":"2024082000250658000_81.7.349.3","unstructured":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans . Polychlorinated Dibenzo-Para-Dioxins and Polychlorinated Dibenzofurans. 69. Lyon, France: International Agency for Research on Cancer, 1997."},{"key":"2024082000250658000_81.7.349.4","unstructured":"IARC Monographs on the Evaluation of Carcinogenic Risks to Humans . 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