{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T22:39:03Z","timestamp":1793659143483,"version":"4.5.1"},"reference-count":54,"publisher":"BMJ","issue":"10","funder":[{"name":"The Labour Market Insurance and the Occupational Diseases Committee","award":["20225100752"],"award-info":[{"award-number":["20225100752"]}]},{"name":"The Labour Market Insurance and the Occupational Diseases Committee","award":["30-2022-09"],"award-info":[{"award-number":["30-2022-09"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2024,9,6]]},"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:p>The risk of developing Dupuytren\u2019s disease among workers exposed to occupational mechanical exposures has been reported in few systematic reviews, mainly related to vibration. Expanding the investigation to all occupational mechanical exposures is essential for advancing scientific knowledge, health policies and improving workplace safety. The aim of this systematic review and meta-analysis was to study the association between occupational mechanical exposures and Dupuytren\u2019s disease.<\/jats:p>\n                  <jats:p>We conducted a systematic review and meta-analysis using guidelines stated by PRISMA. The systematic literature search was performed in Medline, EMBASE, CINAHL, Cochrane Library and Web of Science databases in April 2023. Inclusion criteria were conducted using the PECOS. Two independent authors conducted the literature screening, data extraction and risk of bias assessment. In the meta-analyses, data was pooled using random-effects models and stratified by the risk of bias and study design. The level of evidence was evaluated using GRADE.<\/jats:p>\n                  <jats:p>\n                    The literature search identified 563 unique articles and 15 were deemed eligible for inclusion, categorised into hand-transmitted vibration, lifting\/carrying loads and combined mechanical exposures. Exposure to hand-transmitted vibration showed an OR of 2.0 (95% CI 1.5 to 2.7, I\n                    <jats:sup>2<\/jats:sup>\n                    =64%), lifting\/carrying loads had an OR of 1.5 (95% CI 1.1 to 2.0, I\n                    <jats:sup>2<\/jats:sup>\n                    =77%) and combined mechanical exposures had an OR of 2.1 (95% CI 1.4 to 3.1, I\n                    <jats:sup>2<\/jats:sup>\n                    =94%). When grading the level of evidence, we found moderate evidence for hand-transmitted vibration, while low evidence was found for lifting\/carrying loads and combined mechanical exposures.\n                  <\/jats:p>\n                  <jats:p>We found an association between hand-transmitted vibration, lifting\/carrying loads and combined mechanical exposures. The level of evidence was considered moderate for hand-transmitted vibration and low for lifting\/carrying loads and combined mechanical exposures.<\/jats:p>","DOI":"10.1136\/oemed-2024-109649","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T13:20:42Z","timestamp":1727184042000},"page":"535-542","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Dupuytren\u2019s disease and occupational mechanical exposures: a systematic review and meta-analysis"],"prefix":"10.1136","volume":"81","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6806-0371","authenticated-orcid":false,"given":"Alexander","family":"Jahn","sequence":"first","affiliation":[{"name":"Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, Aarhus N, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johan Hviid","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Occupational Medicine - University Research Clinic, Danish Ramazzini Centre, Regional Hospital Goedstrup, Herning, Denmark"},{"name":"Aarhus University Department of Clinical Medicine, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6028-3186","authenticated-orcid":false,"given":"Alexis","family":"Descatha","sequence":"additional","affiliation":[{"name":"Univ Angers, CHU Angers, Univ Rennes, Inserm, EHESP, Irset (Institut de recherche en sant\u00e9, environnement et travail) - UMR_S 1085, IRSET-ESTER, SFR ICAT, CAPTV CDC, Angers, France"},{"name":"Department of Occupational Medicine, Epidemiology and Prevention, Donald and Barbara Zucker School of Medicine at Hofstra\/Northwell, Hempstead, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annett","family":"Dalb\u00f8ge","sequence":"additional","affiliation":[{"name":"Danish Ramazzini Centre, Department of Occupational Medicine, Aarhus University Hospital, Aarhus N, Denmark"},{"name":"Aarhus University Department of Clinical Medicine, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,9,24]]},"reference":[{"key":"2026051808500765000_81.10.535.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surge.2012.01.004"},{"key":"2026051808500765000_81.10.535.2","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000278455.63546.03"},{"key":"2026051808500765000_81.10.535.3","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-020-01999-7","article-title":"The worldwide prevalence of the Dupuytren disease: a comprehensive systematic review and meta-analysis","volume":"15","author":"Salari","year":"2020","journal-title":"J Orthop Surg Res"},{"key":"2026051808500765000_81.10.535.4","doi-asserted-by":"publisher","DOI":"10.5435\/00124635-199801000-00003"},{"key":"2026051808500765000_81.10.535.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(99)00145-6"},{"key":"2026051808500765000_81.10.535.6","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000438455.37604.0f"},{"key":"2026051808500765000_81.10.535.7","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1101029"},{"key":"2026051808500765000_81.10.535.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhsa.2005.09.018"},{"key":"2026051808500765000_81.10.535.9","doi-asserted-by":"publisher","DOI":"10.1177\/1753193414535720"},{"key":"2026051808500765000_81.10.535.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2017.08.006"},{"key":"2026051808500765000_81.10.535.11","doi-asserted-by":"crossref","DOI":"10.1093\/molbev\/msad130","article-title":"Major Genetic Risk Factors for Dupuytren\u2019s Disease Are Inherited From Neandertals","volume":"40","author":"\u00c5gren","year":"2023","journal-title":"Mol Biol Evol"},{"key":"2026051808500765000_81.10.535.12","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1987.00370060061012"},{"key":"2026051808500765000_81.10.535.13","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000007146"},{"key":"2026051808500765000_81.10.535.14","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-004214","article-title":"Association among work exposure, alcohol intake, smoking and Dupuytren\u2019s disease in a large cohort study (GAZEL)","volume":"4","author":"Descatha","year":"2014","journal-title":"BMJ Open"},{"key":"2026051808500765000_81.10.535.15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-021-94025-7","article-title":"Metabolic factors and the risk of Dupuytren\u2019s disease: data from 30,000 individuals followed for over 20 years","volume":"11","author":"Rydberg","year":"2021","journal-title":"Sci Rep"},{"key":"2026051808500765000_81.10.535.16","doi-asserted-by":"publisher","DOI":"10.1097\/PRS.0000000000004120"},{"key":"2026051808500765000_81.10.535.17","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0274(199605)29:5<521::AID-AJIM12>3.0.CO;2-2"},{"key":"2026051808500765000_81.10.535.18","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2474-12-96","article-title":"Should we consider Dupuytren\u2019s contracture as work-related? 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