{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:06:20Z","timestamp":1784725580122,"version":"3.55.0"},"reference-count":35,"publisher":"BMJ","issue":"4","license":[{"start":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T00:00:00Z","timestamp":1782086400000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006687","name":"Universit\u00e9 Claude Bernard Lyon 1","doi-asserted-by":"publisher","award":["Not applicable"],"award-info":[{"award-number":["Not applicable"]}],"id":[{"id":"10.13039\/501100006687","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["ENV201306\/CLB"],"award-info":[{"award-number":["ENV201306\/CLB"]}],"id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006364","name":"Institut National Du Cancer","doi-asserted-by":"publisher","award":["2013- 721 143"],"award-info":[{"award-number":["2013- 721 143"]}],"id":[{"id":"10.13039\/501100006364","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004431","name":"Fondation de France","doi-asserted-by":"publisher","award":["00099896"],"award-info":[{"award-number":["00099896"]}],"id":[{"id":"10.13039\/501100004431","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2026,4,21]]},"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the association between parental occupational pesticide exposures at birth and adult testicular germ cell tumour (TGCT) by histological subtype and the agreement between two pesticide job-exposure matrices (JEM).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>TGCT cases (n=454) and matched controls (n=670) aged 18\u201345 years were recruited from 20 French university hospitals into the TESTIS national case-control study. Paternal and maternal jobs at birth were obtained from interviews of participants and their mothers\/relatives and coded into official nomenclatures (International Standard Classification of Occupations, French nomenclature of activity-1999). Two complementary JEMs, ALOHA+ and FRIJEM, assessed occupational exposure to all pesticides, herbicides, insecticides, fungicides with ALOHA+ for each parent by linking job titles to JEM-derived probability and intensity estimates (no\/low\/high). Cohen\u2019s Kappa coefficient (\u03ba) assessed their agreement. ORs and 95% CIs comparing exposure and levels of exposure with no exposure were estimated using conditional logistic regression adjusted for literature-based covariates statistically associated with TGCT and stratified by histological subtypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Agreement between ALOHA+and FRIJEM was moderate to substantial (\u03ba 0.52\u20130.80). A statistically non-significant higher TGCT risk was observed for high paternal occupational pesticide exposure with ALOHA+ (OR 1.95, CI 0.98 to 3.84)\u2009and FRIJEM (OR 1.70, CI 0.88 to 3.28). With ALOHA+, statistically significant positive associations were seen for high paternal occupational exposure to herbicides (overall: OR 4.23, CI 1.75 to 10.22; seminomas: OR 4.78, CI 1.79 to 12.77; non-seminomas: OR 3.53, CI 1.21 to 10.3)\u2009and fungicides (overall: OR 2.09, CI 1.05 to 4.18; seminomas: OR 2.31, CI 1.02 to 5.23). No statistically significant associations were observed for other levels of paternal exposure or pesticide groups nor for maternal exposure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Only high paternal occupational exposure to pesticides at birth, especially herbicides and fungicides, was positively associated with TGCT.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/oemed-2024-109893","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T17:20:20Z","timestamp":1782148820000},"page":"195-203","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Parental occupational exposure to pesticides at birth and risk of adult testicular germ cell tumours in offspring: a French nationwide case-control study"],"prefix":"10.1136","volume":"83","clinical-trial-number":[{"clinical-trial-number":"nct02109926","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1166-6145","authenticated-orcid":false,"given":"Ad\u00e8le","family":"Paul","sequence":"first","affiliation":[{"name":"UMRESTTE, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"},{"name":"Occupational Health Department, AMEBAT Service de Prevention et de Sante au Travail du Batiment et des Travaux Publics, Nantes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aur\u00e9lie","family":"Danjou","sequence":"additional","affiliation":[{"name":"Environment and Lifestyle Epidemiology Branch, IARC, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2726-1000","authenticated-orcid":false,"given":"Astrid","family":"Coste","sequence":"additional","affiliation":[{"name":"D\u00e9partement Pr\u00e9vention, Cancer et Environnement, Centre L\u00e9on B\u00e9rard, Lyon, France"},{"name":"UMR1296 Radiation: Defense, Health, Environment, INSERM, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-1890","authenticated-orcid":false,"given":"Hans","family":"Kromhout","sequence":"additional","affiliation":[{"name":"Institute for Risk Assessment Sciences, Utrecht University, Utrecht, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Lefevre","sequence":"additional","affiliation":[{"name":"UMRESTTE, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0943-0790","authenticated-orcid":false,"given":"Johan","family":"Spinosi","sequence":"additional","affiliation":[{"name":"UMRESTTE, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"},{"name":"Direction Sant\u00e9 Travail, Sant\u00e9 publique France, Saint-Maurice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigitte","family":"Dananch\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9partement Pr\u00e9vention, Cancer et Environnement, Centre L\u00e9on B\u00e9rard, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Olsson","sequence":"additional","affiliation":[{"name":"Environment and Lifestyle Epidemiology Branch, IARC, Lyon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Lamouroux","sequence":"additional","affiliation":[{"name":"UMRESTTE, Universit\u00e9 Claude Bernard Lyon 1, Villeurbanne, France"},{"name":"Centre de Ressources en Pathologies Professionnelles et Environnementales, Hospices Civils de Lyon, Lyon, 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