{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T12:53:30Z","timestamp":1792155210412,"version":"4.4.0"},"reference-count":40,"publisher":"BMJ","issue":"2","funder":[{"name":"ADIRAL","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["19-CE36-0005 NIRVANA"],"award-info":[{"award-number":["19-CE36-0005 NIRVANA"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Occup Environ Med"],"accepted":{"date-parts":[[2026,3,15]]},"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The effect of occupational irritants on IgE sensitisation remains unknown. We investigated the association between occupational exposure to irritants and IgE sensitisation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The study included a cross-sectional analysis of 924 adult participants to the first follow-up of the Epidemiological study of the Genetics and Environment of Asthma (EGEA2) and a longitudinal analysis of 271 children recruited at EGEA1 and followed up to adulthood (EGEA2). Allergen-specific IgE sensitisation to 162 allergens was assessed by microarray technology. Lifetime occupational exposure to irritants was evaluated by the occupational asthma-specific job-exposure matrix. Adjusted regression models were performed to evaluate (1) cross-sectional associations between irritant exposures with the number and cluster-based profiles of sIgE sensitisation and (2) longitudinal associations between childhood sIgE sensitisation and occupational irritant exposures in adulthood to assess a potential \u2018healthy hire effect\u2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among adult-onset asthma participants, occupational exposure to irritants was associated with a lower number of sIgE sensitisation (adjusted mean ratio=0.63 (95%\u2009CI 0.39 to 1.02), p=0.06) and a lower risk of exhibiting house dust mite predominant and pollen\/animal predominant sIgE sensitisation profiles (p=0.02\u2009and 0.06 respectively). No association was observed in participants without asthma or with childhood-onset asthma. The longitudinal assessment showed no association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study, showing fewer sIgE sensitisations associated with occupational exposure to irritants in participants with adult-onset asthma but not in those with childhood-onset or no asthma, highlights the need to further explore the non-immunological mechanisms associated with exposure to respiratory irritants at work.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/oemed-2025-110266","type":"journal-article","created":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T17:20:24Z","timestamp":1777310424000},"page":"100-106","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Irritant occupational exposure and specific-IgE sensitisation in the EGEA cohort"],"prefix":"10.1136","volume":"83","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3923-8505","authenticated-orcid":false,"given":"Nicolas","family":"Migueres","sequence":"first","affiliation":[{"name":"Inserm U1209, CNRS UMR5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, IAB, Grenoble Universites, Grenoble, France"},{"name":"Service de Pneumologie et Allergologie, P\u00f4le de Pathologie Thoracique, University Hospital of Strasbourg, Les Hopitaux Universitaires de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8423-2826","authenticated-orcid":false,"given":"Orianne","family":"Dumas","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, Univ. Paris-Sud, \u00c9quipe d\u2019\u00c9pid\u00e9miologie respiratoire int\u00e9grative, CESP, INSERM, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Boudier","sequence":"additional","affiliation":[{"name":"Inserm U1209, CNRS UMR5309, Team of Environmental Epidemiology Applied to Development and Respiratory Health, Institute for Advanced Biosciences, IAB, Grenoble Universites, Grenoble, France"},{"name":"Centre Hospitalier Universitaire Grenoble Alpes, Grenoble, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Bousquet","sequence":"additional","affiliation":[{"name":"Montpellier University, Montpellier, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raph\u00e4elle","family":"Varraso","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, Univ. Paris-Sud, \u00c9quipe d\u2019\u00c9pid\u00e9miologie respiratoire int\u00e9grative, CESP, INSERM, Villejuif, France"},{"name":"UMRS 1018, Universit\u00e9 Paris Sud 11, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Nadif","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, Univ. Paris-Sud, \u00c9quipe d\u2019\u00c9pid\u00e9miologie respiratoire int\u00e9grative, CESP, INSERM, Villejuif, France"},{"name":"UMRS 1018, Universit\u00e9 Paris Sud 11, Villejuif, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf","family":"Valenta","sequence":"additional","affiliation":[{"name":"Division of Immunopathology, Department of Pathophysiology, Center for Pathophysiology and Allergy Research, Infectiology and Immunology, Medical University of Vienna, Vienna General Hospital, Vienna, Austria"},{"name":"Karl Landsteiner University, Krems, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"de Blay","sequence":"additional","affiliation":[{"name":"Service de Pneumologie et Allergologie, P\u00f4le de Pathologie Thoracique, University Hospital of Strasbourg, Les Hopitaux Universitaires de Strasbourg, Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2723-5569","authenticated-orcid":false,"given":"Nicole","family":"Le Moual","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris-Saclay, UVSQ, Univ. 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