{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:06:10Z","timestamp":1792706770012,"version":"4.5.0"},"reference-count":27,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2014,5,24]]},"published-print":{"date-parts":[[2014,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Anthracyclines are successfully used in cancer treatment, but their use is limited by their cardiotoxic side effects. Several risk factors for anthracycline-associated cardiomyopathy (AACM) are known, yet the occurrence of AACM in the absence of these known risk factors suggests that other factors must play a role. The purpose of this study was to evaluate whether a genetic predisposition for dilated cardiomyopathy (DCM) could be a potential risk factor for AACM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A hospital-based registry of 162 DCM families and two hospital-based registries of patients with cancer treated with systemic cancer therapy (n&gt;6000) were reviewed focusing on AACM. Selected patients with AACM\/DCM families with possible AACM (n=21) were analysed for mutations in cardiomyopathy-associated genes and presymptomatic cardiological evaluation of first-degree relatives was performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified five DCM families with AACM and one patient with AACM with a family member with a possible early sign of mild DCM. Pathogenic <jats:italic>MYH7<\/jats:italic> mutations were identified in two of these six families. The <jats:italic>MYH7<\/jats:italic> c.1633G&gt;A (p.Asp545Asn) and c.2863G&gt;A (p.Asp955Asn) mutations (one double mutant allele) were identified in a DCM family with AACM. The <jats:italic>MYH7<\/jats:italic> c.4125T&gt;A (p.Tyr1375X) mutation was identified in one patient with AACM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study further extends the hypothesis that a genetic predisposition to DCM could be a potential risk factor for AACM.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2014-000116","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T23:33:39Z","timestamp":1406072019000},"page":"e000116","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Potential genetic predisposition for anthracycline-associated cardiomyopathy in families with dilated cardiomyopathy"],"prefix":"10.1136","volume":"1","author":[{"given":"Marijke","family":"Wasielewski","sequence":"first","affiliation":[{"name":"Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin Y","family":"van Spaendonck-Zwarts","sequence":"additional","affiliation":[{"name":"Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"},{"name":"Department of Clinical Genetics, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico-Derk L","family":"Westerink","sequence":"additional","affiliation":[{"name":"Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan D H","family":"Jongbloed","sequence":"additional","affiliation":[{"name":"Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleida","family":"Postma","sequence":"additional","affiliation":[{"name":"Department of Paediatric Oncology, University Medical Center Groningen, University of Groningen, Beatrix Children's Hospital, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jourik A","family":"Gietema","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J Peter","family":"van Tintelen","sequence":"additional","affiliation":[{"name":"Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maarten P","family":"van den Berg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, 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