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We propose to capitalise on these associations as powerful and expanding opportunities to diagnose the virulent but silent disease of thoracic aortic aneurysm. This can be accomplished by recognition of this \u2018guilt by association\u2019 with the other conditions. Thus, patients with associated diseases and anatomic variants should be investigated for silent aortic aneurysms. Such a paradigm holds substantial potential for reducing death from the silent killer represented by thoracic aortic aneurysm disease.<\/jats:p>","DOI":"10.1136\/openhrt-2014-000169","type":"journal-article","created":{"date-parts":[[2015,4,24]],"date-time":"2015-04-24T22:07:15Z","timestamp":1429913235000},"page":"e000169","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":99,"title":["Guilt by association: paradigm for detecting a silent killer (thoracic aortic aneurysm)"],"prefix":"10.1136","volume":"2","author":[{"given":"John A","family":"Elefteriades","sequence":"first","affiliation":[{"name":"Aortic Institute at Yale-New Haven, Boardman 2, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam","family":"Sang","sequence":"additional","affiliation":[{"name":"Aortic Institute at Yale-New Haven, Boardman 2, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory","family":"Kuzmik","sequence":"additional","affiliation":[{"name":"Aortic Institute at Yale-New Haven, Boardman 2, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Hornick","sequence":"additional","affiliation":[{"name":"Aortic Institute at Yale-New Haven, Boardman 2, Yale University School of Medicine, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,4,24]]},"reference":[{"key":"2025081710455480000_2.1.e000169.1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2013-304223"},{"key":"2025081710455480000_2.1.e000169.2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000157137.59691.0B"},{"key":"2025081710455480000_2.1.e000169.3","doi-asserted-by":"crossref","unstructured":"Elefteriades JA , Rizzo JA . 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