{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T17:37:08Z","timestamp":1787765828968,"version":"build-2784847793"},"reference-count":23,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2014,11,26]]},"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Transcatheter aortic valve implantation (TAVI) is associated with periprocedural and postprocedural morbidity and mortality. Currently, there is a paucity of risk stratification models for potential TAVI candidates. We employed the CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-Vasc score to quantify the risk of 30-day mortality and morbidity in patients undergoing TAVI.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>A retrospective analysis of registry data for consecutive patients undergoing TAVI at 3 tertiary centres in Northwest England between 2008 and 2013. The CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-Vasc score and its modification\u2014the R<jats:sub>2<\/jats:sub>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-Vasc score, which includes pre-existing renal impairment and pre-existing conduction abnormality (right bundle branch block\/left bundle branch block, RBBB\/LBBB)\u2014were calculated for all patients. A total of 313 patients with a mean age of 80 (79.1\u201380.8) years underwent TAVI. The implanted devices were either the CoreValve or the Edwards-SAPIEN prosthesis. The 30-day mortality was 14.3% in those with a CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-Vasc score \u22656, whereas it was only 6.2% in those with a score &lt;6 (p=0.04). Using the R<jats:sub>2<\/jats:sub>-CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-Vasc score, the difference was more pronounced with a 30-day mortality of 22.6% in those patients with an R<jats:sub>2<\/jats:sub>-CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-Vasc score \u22657 compared to 6.0% in those with a R<jats:sub>2<\/jats:sub>-CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-Vasc score &lt;7 (p=0.001). In multivariable Cox regression analyses, there was a significant and independent relationship between the CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-Vasc score (hazard ratio (HR)= 2.71, (1.01\u00a0to 7.31); p&lt;0.05) and the modified R<jats:sub>2<\/jats:sub>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-Vasc score (HR=4.27 (1.51 to 12.07); p=0.006) with 30-day mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study demonstrates the potential use of the CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-Vasc or the R<jats:sub>2<\/jats:sub>CHA<jats:sub>2<\/jats:sub>DS<jats:sub>2<\/jats:sub>-Vasc score to quantify the risk of mortality in patients undergoing TAVI. This could have significant implications in terms of clinical as well as patients\u2019 decision-making.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2014-000170","type":"journal-article","created":{"date-parts":[[2016,6,8]],"date-time":"2016-06-08T08:14:42Z","timestamp":1465373682000},"page":"e000170","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Does the CHA<sub>2<\/sub>DS<sub>2<\/sub>-Vasc score predict procedural and short-term outcomes in patients undergoing transcatheter aortic valve implantation?"],"prefix":"10.1136","volume":"2","author":[{"given":"Tahir","family":"Hamid","sequence":"first","affiliation":[{"name":"Manchester Royal Infirmary, Central Manchester University NHS Foundation Trust, Manchester, UK"},{"name":"University Hospital of South Manchester NHS Foundation Trust, Wythenshawe, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tawfiq R","family":"Choudhury","sequence":"additional","affiliation":[{"name":"Manchester Royal Infirmary, Central Manchester University NHS Foundation Trust, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon G","family":"Anderson","sequence":"additional","affiliation":[{"name":"Manchester Royal Infirmary, Central Manchester University NHS Foundation Trust, Manchester, UK"},{"name":"Institute of Cardiovascular Sciences, University of Manchester, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Izhar","family":"Hashmi","sequence":"additional","affiliation":[{"name":"Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saqib","family":"Chowdhary","sequence":"additional","affiliation":[{"name":"University Hospital of South Manchester NHS Foundation Trust, Wythenshawe, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hesketh Roberts","sequence":"additional","affiliation":[{"name":"Blackpool Teaching Hospitals NHS Foundation Trust, Blackpool, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas G","family":"Fraser","sequence":"additional","affiliation":[{"name":"Manchester Royal Infirmary, Central Manchester University NHS Foundation Trust, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ragheb","family":"Hasan","sequence":"additional","affiliation":[{"name":"Manchester Royal Infirmary, Central Manchester University NHS Foundation Trust, Manchester, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vaikom S","family":"Mahadevan","sequence":"additional","affiliation":[{"name":"Manchester Royal Infirmary, Central Manchester University NHS Foundation Trust, Manchester, 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