{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:36:49Z","timestamp":1778801809946,"version":"3.51.4"},"reference-count":34,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2015,1,20]]},"published-print":{"date-parts":[[2015,4]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Bundle branch block (BBB) has been regarded as a disease of the conduction system, but occurs in mice lacking connexin 40 (expressed in atria, proximal conduction system) or connexin 43 (expressed in Purkinje cells, cardiomyocytes).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this paper is to explore whether BBB is heritable, and whether polymorphisms at connexin 40 and connexin 43 loci are associated with BBB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>To assess BBB heritability, we screened descendants of men with BBB in the population cohort \u2018The Study of Men Born 1913\u2019. DNA samples from 80-year-old men with extreme QRS-duration phenotypes were used to search for polymorphisms at connexin 40 and 43 loci. Associations between identified polymorphisms and BBB were evaluated in an independent cohort (INTERGENE).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventy-seven men from \u2018The Study of Men Born 1913\u2019 with BBB had 116 descendants. Among the 76 participating descendants, 2 sons (6.4%) had BBB at 54\u2005years of age. At the same age, 0.9% of men born in 1913 had BBB. We identified 6 single nucleotide polymorphisms (SNPs) in connexin 40 and 1 polymorphism in connexin 43. In the INTERGENE cohort, the connexin 43 polymorphism was associated with left BBB (LBBB) (4 of 35 LBBB vs 16 of 232 without BBB, \u03c7<jats:sup>2<\/jats:sup>=7.4, p=0.03), but not with right BBB (RBBB) or overall BBB. None of the connexin 40 SNPs or haplotypes were associated with LBBB or RBBB.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings indicate that conduction by connexin 43 within the ventricular muscle distal to the specialised conduction system may be important for LBBB development.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2014-000187","type":"journal-article","created":{"date-parts":[[2015,4,10]],"date-time":"2015-04-10T23:53:41Z","timestamp":1428710021000},"page":"e000187","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":19,"title":["Genetic variation at the human connexin 43 locus but not at the connexin 40 locus is associated with left bundle branch block"],"prefix":"10.1136","volume":"2","author":[{"given":"Per","family":"Ladenvall","sequence":"first","affiliation":[{"name":"Department of Molecular and Clinical Medicine\/Cardiology, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Andersson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, G\u00f6teborg Pediatric Growth Research Center, Institute of Clinical Sciences, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikael","family":"Dellborg","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine\/Cardiology, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Per-Olof","family":"Hansson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine\/Cardiology, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine\/Cardiology, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dag","family":"Thelle","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Public Health, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Eriksson","sequence":"additional","affiliation":[{"name":"Department of Molecular and Clinical Medicine\/Cardiology, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,4,10]]},"reference":[{"key":"2025081709415512000_2.1.e000187.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2012.09.029"},{"key":"2025081709415512000_2.1.e000187.2","doi-asserted-by":"publisher","DOI":"10.1007\/s12265-011-9344-5"},{"key":"2025081709415512000_2.1.e000187.3","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.98.22.2494"},{"key":"2025081709415512000_2.1.e000187.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCEP.111.963561"},{"key":"2025081709415512000_2.1.e000187.5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-3-303"},{"key":"2025081709415512000_2.1.e000187.6","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-92-1-37"},{"key":"2025081709415512000_2.1.e000187.7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2013.04.005"},{"key":"2025081709415512000_2.1.e000187.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2011.11.014"},{"key":"2025081709415512000_2.1.e000187.9","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.5.399"},{"key":"2025081709415512000_2.1.e000187.10","doi-asserted-by":"publisher","DOI":"10.1006\/jmcc.2000.1308"},{"key":"2025081709415512000_2.1.e000187.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2011.07.039"},{"key":"2025081709415512000_2.1.e000187.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(98)70113-7"},{"key":"2025081709415512000_2.1.e000187.13","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.10.929"},{"key":"2025081709415512000_2.1.e000187.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2009.08.018"},{"key":"2025081709415512000_2.1.e000187.15","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1111\/j.0954-6820.1965.tb01884.x","article-title":"A general health-examination of a random sample of 50-year-old men in goeteborg","volume":"177","author":"Tibblin","year":"1965","journal-title":"Acta Med Scand"},{"key":"2025081709415512000_2.1.e000187.16","first-page":"115","article-title":"Trends in blood lipid levels, blood pressure, alcohol and smoking habits from 1985 to 2002: results from INTERGENE and GOT-MONICA","volume":"12","author":"Berg","year":"2005","journal-title":"Eur J Cardiovasc Prev Rehabil"},{"key":"2025081709415512000_2.1.e000187.17","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1055\/s-0037-1613990","article-title":"Identification of eight novel single-nucleotide polymorphisms at human tissue-type plasminogen activator (t-PA) locus: association with vascular t-PA release in vivo","volume":"84","author":"Ladenvall","year":"2000","journal-title":"Thromb Haemost"},{"key":"2025081709415512000_2.1.e000187.18","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-5273(01)00378-3"},{"key":"2025081709415512000_2.1.e000187.19","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.191095"},{"key":"2025081709415512000_2.1.e000187.20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2005.05613.x"},{"key":"2025081709415512000_2.1.e000187.21","unstructured":"Terwilliger J , Ott J . Linkage disequilibrium between alleles at marker loci. In: Terwilliger J , Ott J , eds. Handbook of human genetic linkage. Baltimore: John Hopkins University Press, 1994:188\u201398."},{"key":"2025081709415512000_2.1.e000187.22","doi-asserted-by":"publisher","DOI":"10.1046\/j.1529-8817.2003.00085.x"},{"key":"2025081709415512000_2.1.e000187.23","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bti473"},{"key":"2025081709415512000_2.1.e000187.24","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkp902"},{"key":"2025081709415512000_2.1.e000187.25","doi-asserted-by":"publisher","DOI":"10.1086\/519795"},{"key":"2025081709415512000_2.1.e000187.26","doi-asserted-by":"publisher","DOI":"10.1136\/heart.84.6.625"},{"key":"2025081709415512000_2.1.e000187.27","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2008.00273.x"},{"key":"2025081709415512000_2.1.e000187.28","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2009.00289.x"},{"key":"2025081709415512000_2.1.e000187.29","doi-asserted-by":"publisher","DOI":"10.1038\/ng.2610"},{"key":"2025081709415512000_2.1.e000187.30","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2012.03.012"},{"key":"2025081709415512000_2.1.e000187.31","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.8.656"},{"key":"2025081709415512000_2.1.e000187.32","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000141134.64811.0a"},{"key":"2025081709415512000_2.1.e000187.33","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.04.060"},{"key":"2025081709415512000_2.1.e000187.34","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.46.4.753"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2014-000187","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T16:42:05Z","timestamp":1755448925000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2014-000187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,4]]},"references-count":34,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,4,10]]},"published-print":{"date-parts":[[2015,4]]}},"alternative-id":["10.1136\/openhrt-2014-000187"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2014-000187","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,4]]}}}