{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T06:41:28Z","timestamp":1780468888395,"version":"3.54.1"},"reference-count":18,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2015,3,4]]},"published-print":{"date-parts":[[2015,5]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Observer variability can influence the assessment of CT coronary angiography (CTCA) and the subsequent diagnosis of angina pectoris due to coronary heart disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We assessed 210 CTCAs from the Scottish COmputed Tomography of the HEART (SCOT-HEART) trial for intraobserver and interobserver variability. Calcium score, coronary angiography and image quality were evaluated. Coronary artery disease was defined as none (&lt;10%), mild (10\u201349%), moderate (50\u201370%) and severe (&gt;70%) luminal stenosis and classified as no (&lt;10%), non-obstructive (10\u201370%) or obstructive (&gt;70%) coronary artery disease. Post-CTCA diagnosis of angina pectoris due to coronary heart disease was classified as yes, probable, unlikely or no.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients had a mean body mass index of 29 (28, 30) kg\/m<jats:sup>2<\/jats:sup>, heart rate of 58 (57, 60)\/min and 62% were men. Intraobserver and interobserver agreements for the presence or absence of coronary artery disease were excellent (95% agreement, \u03ba 0.884 (0.817 to 0.951) and good (91%, 0.791 (0.703 to 0.879)). Intraobserver and interobserver agreement for the presence or absence of angina pectoris due to coronary heart disease were excellent (93%, 0.842 (0.918 to 0.755) and good (86%, 0.701 (0.799 to 0.603)), respectively. Observer variability of calcium score was excellent for calcium scores below 1000. More segments were categorised as uninterpretable with 64-multidetector compared to 320-multidetector CTCA (10.1% vs 2.6%, p&lt;0.001) but there was no difference in observer variability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Multicentre multidetector CTCA has excellent agreement in patients under investigation for suspected angina due to coronary heart disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>NCT01149590.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2014-000234","type":"journal-article","created":{"date-parts":[[2015,5,19]],"date-time":"2015-05-19T22:31:35Z","timestamp":1432074695000},"page":"e000234","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":44,"title":["Observer variability in the assessment of CT coronary angiography and coronary artery calcium score: substudy of the Scottish COmputed Tomography of the HEART (SCOT-HEART) trial"],"prefix":"10.1136","volume":"2","clinical-trial-number":[{"clinical-trial-number":"nct01149590","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Michelle C","family":"Williams","sequence":"first","affiliation":[{"name":"University of Edinburgh\/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Lothian, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj K","family":"Golay","sequence":"additional","affiliation":[{"name":"University of Edinburgh\/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Lothian, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Hunter","sequence":"additional","affiliation":[{"name":"University of Edinburgh\/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Lothian, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan R","family":"Weir-McCall","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular and Diabetes Medicine, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucja","family":"Mlynska","sequence":"additional","affiliation":[{"name":"University of Edinburgh\/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Lothian, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R","family":"Dweck","sequence":"additional","affiliation":[{"name":"University of Edinburgh\/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Lothian, UK"},{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neal G","family":"Uren","sequence":"additional","affiliation":[{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John H","family":"Reid","sequence":"additional","affiliation":[{"name":"Borders General Hospital, Melrose, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steff C","family":"Lewis","sequence":"additional","affiliation":[{"name":"Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Berry","sequence":"additional","affiliation":[{"name":"British Heart Foundation Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edwin J R","family":"van Beek","sequence":"additional","affiliation":[{"name":"University of Edinburgh\/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Lothian, UK"},{"name":"Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giles","family":"Roditi","sequence":"additional","affiliation":[{"name":"Department of Radiology, Glasgow Royal Infirmary, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David E","family":"Newby","sequence":"additional","affiliation":[{"name":"University of Edinburgh\/British Heart Foundation Centre for Cardiovascular Science, University of Edinburgh, Edinburgh, Lothian, UK"},{"name":"Edinburgh Heart Centre, Royal Infirmary of Edinburgh, Edinburgh, UK"},{"name":"Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Mirsadraee","sequence":"additional","affiliation":[{"name":"Clinical Research Imaging Centre, University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2015,5,19]]},"reference":[{"key":"2025081710255537000_2.1.e000234.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0806576"},{"key":"2025081710255537000_2.1.e000234.2","doi-asserted-by":"publisher","DOI":"10.1186\/1745-6215-13-184"},{"key":"2025081710255537000_2.1.e000234.3","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0b013e31817c423e"},{"key":"2025081710255537000_2.1.e000234.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.10.005"},{"key":"2025081710255537000_2.1.e000234.5","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.4040"},{"key":"2025081710255537000_2.1.e000234.6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s10554-012-0095-4","article-title":"Diagnostic accuracy of 320-row computed tomography as compared with invasive coronary angiography in unselected, consecutive patients with suspected coronary artery disease","volume":"29","author":"Pelliccia","year":"2012","journal-title":"Int J Cardiovasc Imaging"},{"key":"2025081710255537000_2.1.e000234.7","doi-asserted-by":"publisher","DOI":"10.1016\/0735-1097(90)90282-T"},{"key":"2025081710255537000_2.1.e000234.8","unstructured":"NICE. Chest pain of recent onset. NICE, 2010."},{"key":"2025081710255537000_2.1.e000234.9","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-012-2389-2"},{"key":"2025081710255537000_2.1.e000234.10","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1007\/s10554-011-9895-1","article-title":"Reproducibility of coronary plaque detection and characterization using low radiation dose coronary computed tomographic angiography in patients with intermediate likelihood of coronary artery disease (ReSCAN study)","volume":"28","author":"\u00d8vrehus","year":"2011","journal-title":"Int J Cardiovasc Imaging"},{"key":"2025081710255537000_2.1.e000234.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcct.2010.03.010"},{"key":"2025081710255537000_2.1.e000234.12","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr157"},{"key":"2025081710255537000_2.1.e000234.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.acra.2008.05.017"},{"key":"2025081710255537000_2.1.e000234.14","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.14140066"},{"key":"2025081710255537000_2.1.e000234.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2008.08.058"},{"key":"2025081710255537000_2.1.e000234.16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10554-009-9522-6","article-title":"Helical prospective ECG-gating in cardiac computed tomography: radiation dose and image quality","volume":"26","author":"DeFrance","year":"2009","journal-title":"Int J Cardiovasc Imaging"},{"key":"2025081710255537000_2.1.e000234.17","doi-asserted-by":"publisher","DOI":"10.12659\/PJR.890732"},{"key":"2025081710255537000_2.1.e000234.18","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.10.5250"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2014-000234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T17:26:04Z","timestamp":1755451564000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2014-000234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,5,19]]},"published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1136\/openhrt-2014-000234"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2014-000234","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5]]}}}