{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T06:31:10Z","timestamp":1768890670459,"version":"3.49.0"},"reference-count":31,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2015,8,2]]},"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Myocardial fibrosis related to non-specific inflammation can be detected using late gadolinium-enhancement cardiovascular MR (LGE-CMR), which is an important prognostic indicator for dilated cardiomyopathy (DCM). The aims of this study were to define the prognostic factors for DCM with LGE-CMR, and to evaluate the impact of the prognostic factors on adverse effects.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a retrospective analysis of a prospectively maintained single centre registry. We analysed the data from 76 patients with DCM who had been admitted for acute heart failure. The primary combined end point was defined as all-cause mortality and rehospitalisation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>LGE-CMR was present in 39 patients (51%), and the mean follow-up period was 813\u00b154\u2005days. The primary end point occurred in 20 patients (5 (13.5%) patients without LGE-CMR and 15 (38.5%) patients with LGE-CMR, p=0.006). Sixteen of 39 patients with LGE-CMR exhibited elevated high-sensitivity C reactive protein (hs-CRP &gt;0.3\u2005mg\/dL). Patients with elevated hs-CRP and LGE-CMR had a significantly higher incidence of the primary end point compared with patients with normal hs-CRP and LGE-CMR (62.5%; 10 patients, 22.7%; 5 patients, respectively, p=0.001). Elevated hs-CRP was significantly associated with the primary end point (HR: 4.04; 95% CI 1.67 to 9.76; p=0.002). After elevated hs-CRP was adjusted for known predictors of DCM, it was still associated with the primary end point (HR: 2.91; 95% CI 1.19 to 7.15; p=0.02).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Among patients with DCM, LGE-CMR and elevated hs-CRP are associated with a higher incidence of the long-term combined end point of all-cause mortality and hospitalisation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number:<\/jats:title>\n                  <jats:p>UMIN000001171.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2015-000298","type":"journal-article","created":{"date-parts":[[2015,10,20]],"date-time":"2015-10-20T00:28:44Z","timestamp":1445300924000},"page":"e000298","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["MRI and serum high-sensitivity C reactive protein predict long-term mortality in non-ischaemic cardiomyopathy"],"prefix":"10.1136","volume":"2","author":[{"given":"Taketaro","family":"Sadahiro","sequence":"first","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, Tokyo, Shinjuku-ku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shun","family":"Kohsaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, Tokyo, Shinjuku-ku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Shinjuku-ku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Inohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, Tokyo, Shinjuku-ku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Shiraishi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, Tokyo, Shinjuku-ku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kohno","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, Tokyo, Shinjuku-ku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Yoshikawa","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiichi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, Tokyo, Shinjuku-ku, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2015,10,19]]},"reference":[{"key":"2025081710141779000_2.1.e000298.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)62023-7"},{"key":"2025081710141779000_2.1.e000298.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200004133421502"},{"key":"2025081710141779000_2.1.e000298.3","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2012.158"},{"key":"2025081710141779000_2.1.e000298.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.508465"},{"key":"2025081710141779000_2.1.e000298.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.07.049"},{"key":"2025081710141779000_2.1.e000298.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.1363"},{"key":"2025081710141779000_2.1.e000298.7","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2010.205542"},{"key":"2025081710141779000_2.1.e000298.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000078641.19365.4C"},{"key":"2025081710141779000_2.1.e000298.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.07.072"},{"key":"2025081710141779000_2.1.e000298.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.05.054"},{"key":"2025081710141779000_2.1.e000298.11","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.86.8.846"},{"key":"2025081710141779000_2.1.e000298.12","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0877"},{"key":"2025081710141779000_2.1.e000298.13","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32835639bb"},{"key":"2025081710141779000_2.1.e000298.14","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.83.6.1849"},{"key":"2025081710141779000_2.1.e000298.15","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.100.16.1734"},{"key":"2025081710141779000_2.1.e000298.16","doi-asserted-by":"publisher","DOI":"10.1159\/000006913"},{"key":"2025081710141779000_2.1.e000298.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2007.03.044"},{"key":"2025081710141779000_2.1.e000298.18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8159.2005.00034.x"},{"key":"2025081710141779000_2.1.e000298.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2012.02.004"},{"key":"2025081710141779000_2.1.e000298.20","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e3182116e39"},{"key":"2025081710141779000_2.1.e000298.21","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.yjmcc.2014.02.015","article-title":"Targeting cardiac fibroblasts to treat fibrosis of the heart: focus on HDACs","volume":"70","author":"Schuetze","year":"2014","journal-title":"J Mol Cell Cardiol"},{"key":"2025081710141779000_2.1.e000298.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.05.002"},{"key":"2025081710141779000_2.1.e000298.23","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.154567"},{"key":"2025081710141779000_2.1.e000298.24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.vph.2013.06.002","article-title":"Effects of interleukin-1 on cardiac fibroblast function: relevance to post-myocardial infarction remodelling","volume":"60","author":"Turner","year":"2014","journal-title":"Vascul Pharmacol"},{"key":"2025081710141779000_2.1.e000298.25","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000013290.12884.A3"},{"key":"2025081710141779000_2.1.e000298.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2003.11.021"},{"key":"2025081710141779000_2.1.e000298.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2005.06.046"},{"key":"2025081710141779000_2.1.e000298.28","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.696906"},{"key":"2025081710141779000_2.1.e000298.29","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1253\/circj.CJ-14-0939","article-title":"Improved Long-Term Prognosis of Dilated Cardiomyopathy With Implementation of Evidenced-Based Medication\u2014Report From the CHART Studies","volume":"79","author":"Ushigome","year":"2015","journal-title":"Circ J"},{"key":"2025081710141779000_2.1.e000298.30","doi-asserted-by":"publisher","DOI":"10.1093\/eurjhf\/hfr156"},{"key":"2025081710141779000_2.1.e000298.31","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-012-0500-y"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2015-000298","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T17:14:21Z","timestamp":1755450861000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2015-000298"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,10]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2015,10,19]]},"published-print":{"date-parts":[[2015,10]]}},"alternative-id":["10.1136\/openhrt-2015-000298"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2015-000298","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,10]]}}}