{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T01:37:25Z","timestamp":1768009045681,"version":"3.49.0"},"reference-count":28,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2016,5,1]]},"published-print":{"date-parts":[[2016,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To address the limited long-term outcome data for catheter ablation (CA) of persistent atrial fibrillation (PeAF), we analysed consecutive ablations performed at our centre from 1 January 2008 to 31 December 2010 and followed patients prospectively until January 2014.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Both arrhythmia recurrence and symptom relief were assessed. Follow-up data were collected from hospital records, supplemented by data from general practitioners and referring hospitals. At the end of the follow-up period, all patients were contacted by phone to determine their up-to-date clinical condition.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>188 consecutive patients with PeAF (157 male, mean age 57.3\u00b19.7\u2005years, 20% with long-standing PeAF) underwent a mean of 1.75 procedures (range 1\u20134). Telephone follow-up was achieved for 77% of surviving patients. Over a mean follow-up of 46\u00b116\u2005months (range 4\u201372), 139 (75%) patients experienced arrhythmia recurrence after a single procedure and 90 (48%) after their final procedure. Median time to first recurrence was 210\u2005days (range 91\u20131850). 71% of recurrences were within the first year following ablation and 91% within 2\u2005years. At final follow-up, 82% of patients reported symptomatic improvement. 7 (2.3%) major complications occurred, and there was no procedure-related death or stroke.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CA for PeAF is safe with a low rate of complications. Over a follow-up period of up to 6\u2005years, a large majority of patients experience significant symptomatic improvement but recurrence after the initial procedure is the norm rather than the exception. 2\u2005years' follow-up is sufficient to observe 90% of AF recurrences, but recurrence can occur even after 5\u2005years' remission.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2015-000394","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T20:09:19Z","timestamp":1469650159000},"page":"e000394","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":28,"title":["Long-term outcomes after ablation of persistent atrial fibrillation: an observational study over 6\u2005years"],"prefix":"10.1136","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1935-8155","authenticated-orcid":false,"given":"Gareth J","family":"Wynn","sequence":"first","affiliation":[{"name":"Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK"},{"name":"Royal Melbourne Hospital, Melbourne, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moutaz","family":"El-Kadri","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iram","family":"Haq","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moloy","family":"Das","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Modi","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Snowdon","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Hall","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan EP","family":"Waktare","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Derick M","family":"Todd","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dhiraj","family":"Gupta","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK"},{"name":"National Heart and Lung Institute, Imperial College London, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2016,7,26]]},"reference":[{"key":"2025081709424548000_3.2.e000394.1","doi-asserted-by":"publisher","DOI":"10.1136\/heart.86.5.516"},{"key":"2025081709424548000_3.2.e000394.2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs253"},{"key":"2025081709424548000_3.2.e000394.3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8167.2011.02010.x"},{"key":"2025081709424548000_3.2.e000394.4","doi-asserted-by":"crossref","unstructured":"Chen HS , Wen JM , Wu SN , et al . 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