{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T10:54:28Z","timestamp":1786359268064,"version":"build-2736575974"},"reference-count":32,"publisher":"BMJ","issue":"1","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2016,4,25]]},"published-print":{"date-parts":[[2016,5]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Acute coronary syndromes (ACS) have been associated with lower health utilities (HUs) compared with the general population. Given the prognostic improvements after ACS with the implementation of coronary angiography (eg, percutaneous coronary intervention (PCI)), contemporary HU values derived from patient-reported outcomes are needed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analysed data of 1882 patients with ACS 1\u2005year after coronary angiography in a Swiss prospective cohort. We used the EuroQol five-dimensional questionnaire (EQ-5D) and visual analogue scale (VAS) to derive HU indexes. We estimated the effects of clinical factors on HU using a linear regression model and compared the observed HU with the average values of individuals of the same sex and age in the general population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Mean EQ-5D HU 1-year after coronary angiography for ACS was 0.82 (\u00b10.16) and mean VAS was 0.77 (\u00b10.18); 40.9% of participants exhibited the highest utility values. Compared with population controls, the mean EQ-5D HU was similar (expected mean 0.82, p=0.58) in patients with ACS, but the mean VAS was slightly lower (expected mean 0.79, p&lt;0.001). Patients with ACS who are younger than 60\u2005years had lower HU than the general population (&lt;0.001). In patients with ACS, significant differences were found according to the gender, education and employment status, diabetes, obesity, heart failure, recurrent ischaemic or incident bleeding event and participation in cardiac rehabilitation (p&lt;0.01).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>At 1 year, patients with ACS with coronary angiography had HU indexes similar to a control population. Subgroup analyses based on patients' characteristics and further disease-specific instruments could provide better sensitivity for detecting smaller variations in health-related quality of life.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2016-000419","type":"journal-article","created":{"date-parts":[[2016,5,23]],"date-time":"2016-05-23T23:14:37Z","timestamp":1464045277000},"page":"e000419","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":16,"title":["Health utility indexes in patients with acute coronary syndromes"],"prefix":"10.1136","volume":"3","clinical-trial-number":[{"clinical-trial-number":"nct01075867","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Baris","family":"Gencer","sequence":"first","affiliation":[{"name":"Cardiology Division, Geneva University Hospitals, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Rodondi","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reto","family":"Auer","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Ambulatory Care, University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Nanchen","sequence":"additional","affiliation":[{"name":"Department of Community Medicine and Ambulatory Care, University of Lausanne, Lausanne, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenz","family":"R\u00e4ber","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Klingenberg","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Pletscher","sequence":"additional","affiliation":[{"name":"Winterthur Institute of Health Economics, Zurich University of Applied Sciences, Winterthur, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"J\u00fcni","sequence":"additional","affiliation":[{"name":"Institute of Primary Health Care, University of Bern, Bern, Switzerland"},{"name":"Applied Health Research Centre (AHRC), Li Ka Shing Knowledge Institute of St. Michael's Hospital, University of Toronto, Toronto, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Windecker","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M","family":"Matter","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas F","family":"L\u00fcscher","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Heart Center, Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Mach","sequence":"additional","affiliation":[{"name":"Cardiology Division, Geneva University Hospitals, University of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas V","family":"Perneger","sequence":"additional","affiliation":[{"name":"Division of Clinical Epidemiology, University Hospital, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois R","family":"Girardin","sequence":"additional","affiliation":[{"name":"Medical Directorate, University Hospital of Geneva, Geneva, Switzerland"},{"name":"Department of Anaesthesiology, Clinical Pharmacology, and Intensive Care Medicine, University Hospitals of Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2016,5,23]]},"reference":[{"key":"2025081710481431000_3.1.e000419.1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehu378"},{"key":"2025081710481431000_3.1.e000419.2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.522"},{"key":"2025081710481431000_3.1.e000419.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.752006"},{"key":"2025081710481431000_3.1.e000419.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehn509"},{"key":"2025081710481431000_3.1.e000419.5","doi-asserted-by":"crossref","unstructured":"Drummond M , Sculpher MJ , Torrance G. Methods of the economic evaluation of health care programmes. 2005.","DOI":"10.1093\/oso\/9780198529446.001.0001"},{"key":"2025081710481431000_3.1.e000419.6","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr236"},{"key":"2025081710481431000_3.1.e000419.7","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X06290495"},{"key":"2025081710481431000_3.1.e000419.8","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7525-8-13"},{"key":"2025081710481431000_3.1.e000419.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.09.078"},{"key":"2025081710481431000_3.1.e000419.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinthera.2005.01.008"},{"key":"2025081710481431000_3.1.e000419.11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4733.2010.00727.x"},{"key":"2025081710481431000_3.1.e000419.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2014.12.014"},{"key":"2025081710481431000_3.1.e000419.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.12.049"},{"key":"2025081710481431000_3.1.e000419.14","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs184"},{"key":"2025081710481431000_3.1.e000419.15","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"2025081710481431000_3.1.e000419.16","doi-asserted-by":"crossref","unstructured":"Krabbe P , et al . Guidelines for analysing and reporting EQ-5D outcomes. In: Brooks R , Rabib R , De Charro F , Eds. The measurement and valuation of health status using EQ-5D: a European perspective. Netherlands: Springer, 2003:7\u201319.","DOI":"10.1007\/978-94-017-0233-1_2"},{"key":"2025081710481431000_3.1.e000419.17","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029334"},{"key":"2025081710481431000_3.1.e000419.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.10.034"},{"key":"2025081710481431000_3.1.e000419.19","doi-asserted-by":"publisher","DOI":"10.1136\/heart.83.6.641"},{"key":"2025081710481431000_3.1.e000419.20","doi-asserted-by":"publisher","DOI":"10.1016\/S0895-4356(98)00028-6"},{"key":"2025081710481431000_3.1.e000419.21","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0904327"},{"key":"2025081710481431000_3.1.e000419.22","doi-asserted-by":"crossref","first-page":"pii: e000901","DOI":"10.1161\/JAHA.114.000901","article-title":"Health-related quality of life in premature acute coronary syndrome: does patient sex or gender really matter?","volume":"3","author":"Leung Yinko","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"2025081710481431000_3.1.e000419.23","doi-asserted-by":"publisher","DOI":"10.1177\/0272989X9301300202"},{"key":"2025081710481431000_3.1.e000419.24","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehs149"},{"key":"2025081710481431000_3.1.e000419.25","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.jval.2013.01.013","article-title":"Health-related quality of life of ticagrelor versus clopidogrel in patients with acute coronary syndromes-results from the PLATO trial","volume":"16","author":"Levin","year":"2013","journal-title":"Value Health"},{"key":"2025081710481431000_3.1.e000419.26","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2014-305864"},{"key":"2025081710481431000_3.1.e000419.27","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.jacc.2014.11.034","article-title":"Economic analysis of ticagrelor therapy from a U.S. perspective: results from the PLATO study","volume":"65","author":"Cowper","year":"2015","journal-title":"J Am Coll Cardiol"},{"key":"2025081710481431000_3.1.e000419.28","doi-asserted-by":"publisher","DOI":"10.1093\/intqhc\/mzq068"},{"key":"2025081710481431000_3.1.e000419.29","first-page":"1863","article-title":"Sex differences in acute coronary syndrome symptom presentation in young patients","volume":"173","author":"Khan","year":"2013","journal-title":"JAMA Intern Med"},{"key":"2025081710481431000_3.1.e000419.30","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2009.176180"},{"key":"2025081710481431000_3.1.e000419.31","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(02)00020-5"},{"key":"2025081710481431000_3.1.e000419.32","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2014-006218"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2016-000419","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T17:48:23Z","timestamp":1755452903000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2016-000419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2016,5,23]]},"published-print":{"date-parts":[[2016,5]]}},"alternative-id":["10.1136\/openhrt-2016-000419"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2016-000419","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5]]}}}