{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T14:00:10Z","timestamp":1789653610800,"version":"4.0.0"},"reference-count":39,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2018,8,14]]},"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this study was to compare the prevalence of left ventricle non-compaction (LVNC) criteria (or hypertrabeculation) in a cohort of patients with bicuspid aortic valve (BAV) and healthy control subjects (CTL) without cardiovascular disease using cardiovascular MR (CMR).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>79 patients with BAV and 85 CTL with tricuspid aortic valve and free of known cardiovascular disease underwent CMR to evaluate the presence of LVNC criteria. The left ventricle was assessed at end-systole and end-diastole, in the short-axis, two-chamber and four-chamber views and divided into the 16 standardised myocardial segments. LVNC was assessed using the non-compacted\/compacted (NC\/C) myocardium ratio and was considered to be present if at least one of the myocardial segments had a NC\/C ratio superior to the cut-off values defined in previous studies: Jenni <jats:italic>et al<\/jats:italic> (&gt;2.0 end-systole); Petersen <jats:italic>et al<\/jats:italic> (&gt;2.3 end-diastole); or Fazio <jats:italic>et al<\/jats:italic> (&gt;2.5 end-diastole).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>15 CTL (17.6%) vs 8 BAV (10.1%) fulfilled Jenni <jats:italic>et al<\/jats:italic>\u2019s criterion; 69 CTL (81.2%) vs 49 BAV (62.0%) fulfilled Petersen <jats:italic>et al<\/jats:italic>\u2019s criterion; and 66 CTL (77.6%) vs 43 BAV (54.4%) fulfilled Fazio <jats:italic>et al<\/jats:italic>\u2019s criterion. Petersen <jats:italic>et al<\/jats:italic> and Fazio <jats:italic>et al<\/jats:italic>\u2019s LVNC criteria were met more often by CTL (p=0.006\u2009and p=0.002, respectively) than patients with BAV, whereas this difference was not statistically significant according to Jenni <jats:italic>et al<\/jats:italic>\u2019s criterion (p=0.17). In multivariable analyses, after adjusting for age, sex, the presence of significant valve dysfunction (&gt;mild stenosis or &gt;mild regurgitation), indexed LV mass, indexed LV end-diastolic volume and LV ejection fraction, BAV was not associated with any of the three LVNC criteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients with BAV do not harbour more LVNC than the general population and there is no evidence that they are at higher risk for the development of LVNC cardiomyopathy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2018-000869","type":"journal-article","created":{"date-parts":[[2018,10,7]],"date-time":"2018-10-07T23:35:11Z","timestamp":1538955311000},"page":"e000869","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Prevalence of left ventricle non-compaction criteria in adult patients with bicuspid aortic valve versus healthy control subjects"],"prefix":"10.1136","volume":"5","clinical-trial-number":[{"clinical-trial-number":"nct01679431","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Myl\u00e8ne","family":"Shen","sequence":"first","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec \/ Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Capoulade","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec \/ Quebec Heart & Lung Institute, Laval University, Quebec City, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lionel","family":"Tastet","sequence":"additional","affiliation":[{"name":"Institut Universitaire de Cardiologie et de Pneumologie de Qu\u00e9bec \/ Quebec Heart & Lung Institute, 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