{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T18:14:08Z","timestamp":1781720048516,"version":"3.54.5"},"reference-count":21,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2018,9,20]]},"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>Cardiac resynchronisation therapy (CRT) is effective treatment for selected patients with heart failure (HF) but has ~30% non-response rate. We evaluated whether specific biomarkers can predict outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A prospective single-centre pilot study of consecutive unselected patients undergoing CRT for HF between November 2013 and December 2015 evaluating cardiac extracellular matrix biomarkers and micro-ribonucleic acid (miRNA) expression before and after CRT assessing ability to predict functional response and survival. Each underwent three assessments (pre-implant, 6 \u2009weeks and 6 \u2009months postimplant) including: New York Heart Association (NYHA) class, echocardiography, electrocardiography, 6 \u2009min walk test (6MWT), Minnesota Living with Heart Failure Questionnaire (MLHFQ) and N-terminal pro-brain natriuretic peptide (NT-pro-BNP). Plasma markers of cardiac fibrosis assessed were: N-terminal pro-peptides of collagen I and III, collagen I C-terminal telopeptides (CTx) and matrix metalloproteinases (MMP-2 and MMP-9) as well as a panel of miRNAs (miRNA-21, miRNA-30d, miRNA-122, miRNA-133a, miRNA-210 and miRNA-486).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 52 patients were recruited; mean age (\u00b1SD) was 72.4\u00b19.4 years; male=43 (82.7%), ischaemic aetiology=30 (57.7%), mean QRS duration=166.4\u00b123.5 \u2009ms, left bundle branch block (LBBB) morphology = 39 (75.0%), mean NYHA=2.7\u00b10.6, 6MWT=238.8\u00b1130.6 \u2009m, MLHFQ=46.4\u00b121.3 \u2009and left ventricular ejection fraction (LVEF)=24.3%\u00b18.0%. Mean follow-up=1.7\u00b10.3 \u2009and 5.8\u00b10.7 months. There were 27 (55.1%) functional responders (3 no definable 6-month response; 2 missed assessments and 1 long-term lead displacement). No marker predicted response, however, CTx and LBBB trended most towards predicting functional response.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>No specific biomarkers reached significance for predicting functional response to CRT. CTx showed a trend towards predicting response and warrants further study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT02541773\">NCT02541773<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2018-000899","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:05:33Z","timestamp":1539907533000},"page":"e000899","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Characterisation of circulating biomarkers before and after cardiac resynchronisation therapy and their role in predicting CRT response: the COVERT-HF study"],"prefix":"10.1136","volume":"5","clinical-trial-number":[{"clinical-trial-number":"nct02541773","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct02541773","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Christopher J","family":"McAloon","sequence":"first","affiliation":[{"name":"Department of Cardiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK"},{"name":"Warwick Medical School, University of Warwick , Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Temo","family":"Barwari","sequence":"additional","affiliation":[{"name":"King's British Heart Foundation Centre, King's College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jimiao","family":"Hu","sequence":"additional","affiliation":[{"name":"Warwick Medical School, University of Warwick , Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Hamborg","sequence":"additional","affiliation":[{"name":"Warwick Medical School, University of Warwick , Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Nevill","sequence":"additional","affiliation":[{"name":"Faculty of Education, Health and Wellbeing, University of Wolverhampton, Wolverhampton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha","family":"Hyndman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Ansell","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anntoniette","family":"Musa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Jones","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Goodby","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7793-1733","authenticated-orcid":false,"given":"Prithwish","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK"},{"name":"Warwick Medical School, University of Warwick , Coventry, UK"},{"name":"Faculty of Health and Life Sciences, University of Coventry, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"O\u2019Hare","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK"},{"name":"Warwick Medical School, University of Warwick , Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Mayr","sequence":"additional","affiliation":[{"name":"King's British Heart Foundation Centre, King's College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harpal","family":"Randeva","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK"},{"name":"Warwick Medical School, University of Warwick , Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faizel","family":"Osman","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Coventry and Warwickshire NHS Trust, Coventry, UK"},{"name":"Warwick Medical School, University of Warwick , Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"2025081710422090000_5.2.e000899.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa050496"},{"key":"2025081710422090000_5.2.e000899.2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2011.165720"},{"key":"2025081710422090000_5.2.e000899.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.112.266882"},{"key":"2025081710422090000_5.2.e000899.4","doi-asserted-by":"crossref","DOI":"10.1136\/openhrt-2017-000639","article-title":"Extracellular cardiac matrix biomarkers in patients with reduced ejection fraction 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Implantable cardioverter defibrillators and cardiac resynchronisation therapy for arrhythmias and heart failure (review of TA95 and TA120). 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