{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:54:00Z","timestamp":1784130840920,"version":"3.55.0"},"reference-count":26,"publisher":"BMJ","issue":"2","content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2018,8,22]]},"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Patients with univentricular hearts (UVH) have high mortality despite modern treatment, and better methods to identify patients at highest risk are needed. We wanted to improve risk stratification in patients with UVH by focusing on the prognostic significance of single right versus single left ventricular morphology (SRV vs SLV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>All 395 patients with UVH operated at our centre were prospectively included from 1972 to 2016 (195 SRV, 166 SLV, 34 mixed or indeterminate ventricular morphology). Diagnoses, UVH morphology, types of all operations and time and causes of death or heart transplantation (HTX) were recorded. The primary endpoint was death or HTX.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among the 111 non-Fontan patients, 88 died (SRV 62 vs SLV 20; p&lt;0.0001), 32 due to heart failure (SRV 23 vs SLV 5; p=0.0012). Twenty-five \u2009years of cumulative SRV versus SLV survival among the 284 Fontan patients (41 deaths\/HTX) was 66.9% vs 87.9% (p=0.0027), partly explained by more deaths\/HTX due to heart failure among patients with SRV (p=0.0006). Survival in patients with SRV with and without hypoplastic left heart syndrome (HLHS) was similar. SRV versus SLV was a strong predictor of death\/HTX in multivariable proportional hazards analyses (RR 3.3, 95% CI 1.6 to 6.6).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>SRV versus SLV is a strong short-term and long-term predictor of survival among patients with UVH, mainly explained by higher rates of death\/HTX due to heart failure in the SRV group. Our findings apply to patients with SRV both with and without HLHS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2018-000902","type":"journal-article","created":{"date-parts":[[2018,10,19]],"date-time":"2018-10-19T00:05:35Z","timestamp":1539907535000},"page":"e000902","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":33,"title":["Survival in patients with univentricular hearts: the impact of right versus left ventricular morphology"],"prefix":"10.1136","volume":"5","author":[{"given":"Gunnar","family":"Erikssen","sequence":"first","affiliation":[{"name":"ACHD Unit, Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamil","family":"Aboulhosn","sequence":"additional","affiliation":[{"name":"Ahmanson\/UCLA Adult Congenital Heart Disease Center, UCLA Medical Plaza, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeannette","family":"Lin","sequence":"additional","affiliation":[{"name":"Ahmanson\/UCLA Adult Congenital Heart Disease Center, UCLA Medical Plaza, Los Angeles, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Knut","family":"Liest\u00f8l","sequence":"additional","affiliation":[{"name":"Department of Informatics, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette E","family":"Estensen","sequence":"additional","affiliation":[{"name":"ACHD Unit, Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Gjesdal","sequence":"additional","affiliation":[{"name":"ACHD Unit, Department of Cardiology, Oslo University Hospital Rikshospitalet, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Skulstad","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Institute of Clinical Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaute","family":"D\u00f8hlen","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald Lauritz","family":"Lindberg","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2018,10,18]]},"reference":[{"key":"2025081711145534000_5.2.e000902.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.748566"},{"key":"2025081711145534000_5.2.e000902.2","first-page":"138","article-title":"Percutaneous interventions in Fontan circulation","volume":"8","author":"Franco","year":"2015","journal-title":"Int J Cardiol Heart Vasc"},{"key":"2025081711145534000_5.2.e000902.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.007764"},{"key":"2025081711145534000_5.2.e000902.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.012033"},{"key":"2025081711145534000_5.2.e000902.5","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2016-310108"},{"key":"2025081711145534000_5.2.e000902.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.07.065"},{"key":"2025081711145534000_5.2.e000902.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.107.738559"},{"key":"2025081711145534000_5.2.e000902.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.11.049"},{"key":"2025081711145534000_5.2.e000902.9","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezu015"},{"key":"2025081711145534000_5.2.e000902.10","doi-asserted-by":"publisher","DOI":"10.1007\/BF02424983"},{"key":"2025081711145534000_5.2.e000902.11","doi-asserted-by":"publisher","DOI":"10.1017\/S1047951106001284"},{"key":"2025081711145534000_5.2.e000902.12","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.41.5.544"},{"key":"2025081711145534000_5.2.e000902.13","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1053\/j.pcsu.2011.01.019","article-title":"Extracardiac versus intra-atrial lateral tunnel fontan: extracardiac is better","volume":"14","author":"Backer","year":"2011","journal-title":"Semin Thorac Cardiovasc Surg"},{"key":"2025081711145534000_5.2.e000902.14","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/S0022-5223(19)35174-8","article-title":"Total cavopulmonary connection: a logical alternative to atriopulmonary connection for complex Fontan operations. 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