{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T06:19:42Z","timestamp":1785392382579,"version":"3.55.0"},"reference-count":21,"publisher":"BMJ","issue":"1","funder":[{"name":"REVA Medical Inc., San Diego, U.S."}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2019,1,20]]},"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to evaluate the mechanical properties and healing patterns 6 and 9 months after implantation of the sirolimus-eluting Fantom bioresorbable scaffold (BRS).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The Fantom BRS (Reva Medical, San Diego, USA) has differentiating properties including radiopacity, strut thickness of 125 \u00b5m, high expansion capacity and has demonstrated favourable mid-term clinical and angiographic outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and results<\/jats:title>\n                  <jats:p>FANTOM II was a prospective, single arm study with implantation of the Fantom BRS in 240 patients with stable angina pectoris. Guidance by optical coherence tomography (OCT) was encouraged and was repeated at 6-month (cohort A) or 9-month follow-up (cohort B). Matched baseline and follow-up OCT recordings were available in 152 patients. In-scaffold mean lumen area in cohort A was 6.8\u00b11.7\u2009mm<jats:sup>2<\/jats:sup> and 5.7\u00b11.4\u2009mm<jats:sup>2<\/jats:sup> at baseline and follow-up (p&lt;0.0001) and was 7.2\u00b11.6\u2009mm<jats:sup>2<\/jats:sup> and 5.6\u00b11.4\u2009mm<jats:sup>2<\/jats:sup> in cohort B (p&lt;0.0001). Mean scaffold area remained stable from 7.1\u00b11.5\u2009mm<jats:sup>2<\/jats:sup> at baseline to 7.2\u00b11.4\u2009mm<jats:sup>2<\/jats:sup> at 6 months (p=0.12), and from 7.4\u00b11.5\u2009mm<jats:sup>2<\/jats:sup> to 7.3\u00b11.4\u2009mm<jats:sup>2<\/jats:sup> at 9 months. Strut malapposition was median 0.8 (IQR 0.0;3.5)% and 1.8 (IQR 0.3;6.0)% at baseline and was 0.0 (IQR 0.0;0.0)% in both groups at 6-month and 9-month follow-up. Strut tissue coverage was 98.1 (IQR 95.9;99.4)% at 6 months and 98.9 (IQR 98.3;100.0)% at 9 months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The novel Fantom BRS had favourable healing patterns at 6-month and 9-month follow-up as malapposition was effectively resolved and strut coverage was almost complete. The scaffold remained stable through follow-up with no signs of systematic late recoil.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2018-000941","type":"journal-article","created":{"date-parts":[[2019,2,28]],"date-time":"2019-02-28T13:36:54Z","timestamp":1551361014000},"page":"e000941","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["Mechanical performance and healing patterns of the novel sirolimus-eluting bioresorbable Fantom scaffold: 6-month and 9-month follow-up by optical coherence tomography in the FANTOM II study"],"prefix":"10.1136","volume":"6","clinical-trial-number":[{"clinical-trial-number":"nct02539966","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Jo Krogsgaard","family":"Simonsen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil Nielsen","family":"Holck","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Carri\u00e9","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Hospital Rangueil, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Frey","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Medical Center Schleswig-Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Lutz","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Angiology, University Medical Center Schleswig-Holstein, Kiel, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joachim","family":"Weber-Albers","sequence":"additional","affiliation":[{"name":"St. Johannes-Hospital, Dortmund, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dariusz","family":"Dudek","sequence":"additional","affiliation":[{"name":"Institute of Cardiology, Jagiellonian University Medical College, University Hospital, Krakow, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Chevalier","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Institut Cardiovasculaire Paris Sud, Massy, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost","family":"Daemen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Erasmus Universiteit Rotterdam, Rotterdam, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jouke","family":"Dijkstra","sequence":"additional","affiliation":[{"name":"Division of Image Processing, Leiden University Medical Center, Leiden, Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Fox Maule","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omeed","family":"Neghabat","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Flensted","family":"Lassen","sequence":"additional","affiliation":[{"name":"The Heart Center, Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Anderson","sequence":"additional","affiliation":[{"name":"REVA Medical Inc, San Diego, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evald H\u00f8j","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Abizaid","sequence":"additional","affiliation":[{"name":"Instituto de Cardiologia Dante Pazzanese, Sao Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels Ramsing","family":"Holm","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2019,2,28]]},"reference":[{"key":"2025081711123712000_6.1.e000941.1","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.4244\/EIJY16M08_01","article-title":"Randomised comparison of a bioresorbable everolimus-eluting scaffold with a metallic everolimus-eluting stent for ischaemic heart disease caused by de novo native coronary artery lesions: the 2-year clinical outcomes of the absorb II trial","volume":"12","author":"Chevalier","year":"2016","journal-title":"EuroIntervention"},{"key":"2025081711123712000_6.1.e000941.2","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.4244\/EIJY16M09_01","article-title":"Two-year clinical, angiographic, and serial optical coherence tomographic follow-up after implantation of an everolimus-eluting bioresorbable scaffold and an everolimus-eluting metallic stent: insights from the randomised absorb Japan trial","volume":"12","author":"Onuma","year":"2016","journal-title":"EuroIntervention"},{"key":"2025081711123712000_6.1.e000941.3","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1016\/S0140-6736(16)32050-5","article-title":"Comparison of an everolimus-eluting bioresorbable scaffold with an everolimus-eluting metallic stent for the treatment of coronary artery stenosis (absorb II): a 3 year, randomised, controlled, single-blind, multicentre clinical trial","volume":"388","author":"Serruys","year":"2016","journal-title":"The Lancet"},{"key":"2025081711123712000_6.1.e000941.4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2014.06.016"},{"key":"2025081711123712000_6.1.e000941.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.07.026"},{"key":"2025081711123712000_6.1.e000941.6","doi-asserted-by":"publisher","DOI":"10.4244\/EIJY15M02_03"},{"key":"2025081711123712000_6.1.e000941.7","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.4244\/EIJY15M07_02","article-title":"Bioabsorbable vascular scaffold overexpansion: insights from in vitro post-expansion experiments","volume":"11","author":"Foin","year":"2016","journal-title":"EuroIntervention"},{"key":"2025081711123712000_6.1.e000941.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2017.07.033"},{"key":"2025081711123712000_6.1.e000941.9","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.110.970772"},{"key":"2025081711123712000_6.1.e000941.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.12.018"},{"key":"2025081711123712000_6.1.e000941.11","first-page":"996","article-title":"Long-term invasive follow-up of the everolimus-eluting bioresorbable vascular scaffold: five-year results of multiple invasive imaging modalities","volume":"11","author":"Simsek","year":"2016","journal-title":"EuroIntervention"},{"key":"2025081711123712000_6.1.e000941.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.11.060"},{"key":"2025081711123712000_6.1.e000941.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2013.05.034"},{"key":"2025081711123712000_6.1.e000941.14","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(03)00119-0"},{"key":"2025081711123712000_6.1.e000941.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.12.019"},{"key":"2025081711123712000_6.1.e000941.16","doi-asserted-by":"crossref","first-page":"834","DOI":"10.4244\/EIJV12I7A138","article-title":"Bioresorbable vascular scaffold radial expansion and conformation compared to a metallic platform: insights from in vitro expansion in a coronary artery lesion model","volume":"12","author":"Foin","year":"2016","journal-title":"EuroIntervention"},{"key":"2025081711123712000_6.1.e000941.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2015.11.005"},{"key":"2025081711123712000_6.1.e000941.18","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.ijcard.2016.06.096","article-title":"Prevalence of parameters of suboptimal scaffold deployment following angiographic guided bioresorbable vascular scaffold implantation in real world practice - an optical coherence tomography analysis","volume":"220","author":"Subban","year":"2016","journal-title":"Int J Cardiol"},{"key":"2025081711123712000_6.1.e000941.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2006.03.042"},{"key":"2025081711123712000_6.1.e000941.20","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000116202.41966.D4"},{"key":"2025081711123712000_6.1.e000941.21","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv581"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2018-000941","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T18:12:44Z","timestamp":1755454364000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2018-000941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,2,28]]},"published-print":{"date-parts":[[2019,2]]}},"alternative-id":["10.1136\/openhrt-2018-000941"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2018-000941","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2]]}}}