{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T11:41:46Z","timestamp":1771674106476,"version":"3.50.1"},"reference-count":21,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2020,3,18]],"date-time":"2020-03-18T00:00:00Z","timestamp":1584489600000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2020,2,20]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>In Thailand, due to limited availability of percutaneous coronary intervention (PCI)-capable hospitals, a number of patients with ST-elevation myocardial infarction (STEMI) after fibrinolytic therapy underwent the delayed coronary intervention (24\u2009hours to 2 weeks). Existing tool such as the Global Registry of Acute Coronary Event (GRACE) to define patients at high risk of cardiovascular outcomes has been used widely, except for patients who had the delayed coronary intervention. We, therefore, evaluated the cardiovascular outcomes of STEMI patients who underwent the delayed coronary intervention.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively analysed the data from the PCI-capable hospital (Maharaj Nakorn Chiang Mai Hospital) STEMI registry during the period 2007\u20132012. Patients who received fibrinolytic treatment (SK) and underwent the delayed coronary intervention were included. The outcomes of the study were 30-day and 6-month composite cardiovascular outcomes (including death, re-hospitalised with acute coronary syndrome, re-hospitalised with heart failure and stroke).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of all 341 patients included, 229 (67.2%) patients were in the low GRACE score group (&lt;126 points) and 112 (32.8%) patients in the intermediate-high GRACE score group (\u2265126 points). At 30 days, the composite cardiovascular outcome occurred in 2.2% (n=5) in the low GRACE score group and 11.6% (n=13) in the intermediate-high GRACE score group (p value=0.001). At 6 months, the composite cardiovascular outcomes occurred in 3.9% (n=9) in the low GRACE score group and 13.4% (n=15) in the intermediate-high GRACE score group (p value=0.003). The area under the receiver operating characteristic curve of GRACE score for 6-month composite cardiovascular outcomes was 0.746 (95% CI 0.698 to 0.793).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Intermediate-high GRACE risk STEMI patients after fibrinolytic therapy in limited PCI-capable hospital who underwent the delayed coronary intervention increased 30-day and 6-month cardiovascular outcomes compared with the low GRACE risk patients. In limited available PCI-capable hospital, GRACE risk score can be helpful in guiding the cardiologists to select a proper time for coronary intervention in post-fibrinolytic STEMI patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2019-001133","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T05:35:19Z","timestamp":1584596119000},"page":"e001133","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["GRACE score and cardiovascular outcomes prediction among the delayed coronary intervention after post-fibrinolytic STEMI patients in a limited PCI-capable hospital"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2531-2900","authenticated-orcid":false,"given":"Yotsawee","family":"Chotechuang","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Lampang Hospital, Lampang, Thailand"},{"name":"Clinical Epidemiology Program, Clinical Epidemiology and Clinical Statistics Center, Department of Clinical Epidemiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arintaya","family":"Phrommintikul","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srun","family":"Kuanprasert","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roungtiva","family":"Muenpa","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Lampang Hospital, Lampang, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chidchanok","family":"Ruengorn","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Care, Faculty of Pharmacy, Chiangmai University, Chiang Mai, Thailand"},{"name":"Pharmacoepidemiology and Statistics Research Center (PESRC), Faculty of Pharmacy, Chiangmai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayanton","family":"Patumanond","sequence":"additional","affiliation":[{"name":"Center of Excellence in Applied Epidemiology, Faculty of Medicine, Thammasat University, Pathumthani, Thailand"},{"name":"Department of Clinical Epidemiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuanchai","family":"Chaichuen","sequence":"additional","affiliation":[{"name":"Cardiac Catheterization Laboratory Unit, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noparat","family":"Thanachaikun","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanawat","family":"Benjanuwatra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Apichard","family":"Sukonthasarn","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 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