{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T07:12:27Z","timestamp":1767165147814,"version":"build-2238731810"},"reference-count":34,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T00:00:00Z","timestamp":1578528000000},"content-version":"unspecified","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007437","name":"TrygFonden","doi-asserted-by":"publisher","award":["125317"],"award-info":[{"award-number":["125317"]}],"id":[{"id":"10.13039\/501100007437","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2019,12,12]]},"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To enhance adherence to cardiac rehabilitation (CR), a patient education programme called \u2018learning and coping\u2019 (LC-programme) was implemented in three hospitals in Denmark. The aim of this study was to investigate the cost\u2013utility of the LC-programme compared with the standard CR-programme.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>825 patients with ischaemic heart disease or heart failure were randomised to the LC-programme or the standard CR-programme and were followed for 3\u2009years.<\/jats:p>\n                    <jats:p>A societal cost perspective was applied and quality-adjusted life years (QALY) were based on SF-6D measurements. Multiple imputation technique was used to handle missing data on the SF-6D. The statistical analyses were based on means and bootstrapped SEs. Regression framework was employed to estimate the net benefit and to illustrate cost-effectiveness acceptability curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No statistically significant differences were found between the two programmes in total societal costs (4353 Euros; 95%\u2009CI \u20133828 to 12 533) or in QALY (\u20130.006; 95%\u2009CI \u20130.053 to 0.042). At a threshold of 40\u2009000 Euros, the LC-programme was found to be cost-effective at 15% probability; however, for patients with heart failure, due to increased cost savings, the probability of cost-effectiveness increased to 91%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While the LC-programme did not appear to be cost-effective in CR, important heterogeneity was noted for subgroups of patients. The LC-programme was demonstrated to increase adherence to the rehabilitation programme and to be cost-effective among patients with heart failure. However, further research is needed to study the dynamic value of heterogeneity due to the small sample size in this subgroup.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2019-001184","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T06:15:13Z","timestamp":1578550513000},"page":"e001184","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Cost\u2013utility analysis of learning and coping versus standard education in cardiac rehabilitation: a randomised controlled trial with 3 years of follow-up"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6717-5003","authenticated-orcid":false,"given":"Nasrin","family":"Tayyari Dehbarez","sequence":"first","affiliation":[{"name":"DEFACTUM, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Palmh\u00f8j Nielsen","sequence":"additional","affiliation":[{"name":"DEFACTUM, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bettina Wulff","family":"Ris\u00f8r","sequence":"additional","affiliation":[{"name":"DEFACTUM, Aarhus N, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus","family":"Vinther Nielsen","sequence":"additional","affiliation":[{"name":"DEFACTUM, Aarhus N, Denmark"},{"name":"Department of Public Health, Aarhus Universitet, Aarhus C, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vibeke","family":"Lynggaard","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Regional Hospital West Jutland, Herning, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,1,8]]},"reference":[{"key":"2025081710424250000_7.1.e001184.1","doi-asserted-by":"publisher","DOI":"10.1097\/00149831-200512000-00001"},{"key":"2025081710424250000_7.1.e001184.2","doi-asserted-by":"crossref","DOI":"10.1186\/1472-6963-12-243","article-title":"A systematic review of economic evaluations of cardiac rehabilitation","volume":"12","author":"Wong","year":"2012","journal-title":"BMC Health Serv Res"},{"key":"2025081710424250000_7.1.e001184.3","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1177\/2047487317689908","article-title":"Cost\u2013utility analysis of cardiac rehabilitation after conventional heart valve surgery versus usual care","volume":"24","author":"Hansen","year":"2017","journal-title":"Eur J Prev Cardiol"},{"key":"2025081710424250000_7.1.e001184.4","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2261-14-186","article-title":"LC-REHAB: randomised trial assessing the effect of a new patient education method\u2014learning and coping strategies\u2014in cardiac rehabilitation","volume":"14","author":"Lynggaard","year":"2014","journal-title":"BMC Cardiovasc Disord"},{"key":"2025081710424250000_7.1.e001184.5","unstructured":"Scholte op Reimer W , Gitt A , Boersma E , et al . 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