{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T10:57:00Z","timestamp":1761562620038,"version":"3.44.0"},"reference-count":23,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2020,3,23]],"date-time":"2020-03-23T00:00:00Z","timestamp":1584921600000},"content-version":"unspecified","delay-in-days":22,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Boehringer Ingelheim International GmbH"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2020,2,10]]},"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We evaluated atrial fibrillation (AF) patients\u2019 perceptions of anticoagulation treatment with dabigatran or a vitamin K antagonist (VKA) for stroke prevention, according to accepted indications.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The RE-SONANCE observational, prospective, multicentre, international study used the validated Perception on Anticoagulant Treatment Questionnaire (PACT-Q) to assess patients with AF already taking a VKA who were switched to dabigatran (cohort A), and newly diagnosed patients initiated on either dabigatran or a VKA (cohort B). Visit 1 (V1) was at baseline, and visit 2 (V2) and visit 3 (V3) were at 30\u201345 and 150\u2013210 days after baseline, respectively. Primary outcomes were treatment satisfaction and convenience in cohort A at V2 and V3 versus baseline, and in cohort B for dabigatran and a VKA at V2 and V3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The main analysis set comprised 4100 patients in cohort A and 5365 in cohort B (dabigatran: 3179; VKA: 2186). In cohort A, PACT-Q2 improved significantly (p&lt;0.001 for all) for treatment convenience (mean change V1 vs V2=20.72; SD=21.50; V1 vs V3=24.54; SD=22.85) and treatment satisfaction (mean change V1 vs V2=17.60; SD=18.76; V1 vs V3=21.04; SD=20.24). In cohort B, mean PACT-Q2 scores at V2 and V3 were significantly higher (p&lt;0.001 for all) for dabigatran versus a VKA for treatment convenience (V2=18.38; SE =0.51; V3=23.34; SE=0.51) and satisfaction (V2=15.88; SE=0.39; V3=19.01; SE=0.41).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Switching to dabigatran from long-term VKA therapy or newly initiated dabigatran is associated with improved patient treatment convenience and satisfaction compared with VKA therapy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2019-001202","type":"journal-article","created":{"date-parts":[[2020,3,24]],"date-time":"2020-03-24T15:44:36Z","timestamp":1585064676000},"page":"e001202","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Patient perception of anticoagulant treatment for stroke prevention (RE-SONANCE study)"],"prefix":"10.1136","volume":"7","clinical-trial-number":[{"clinical-trial-number":"nct02684981","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Dragos","family":"Vinereanu","sequence":"first","affiliation":[{"name":"Cardiology, University and Emergency Hospital of Bucharest, Bucharest, Other, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dmitry","family":"Napalkov","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Bergler-Klein","sequence":"additional","affiliation":[{"name":"Department of Cardiology, University Clinic of Internal Medicine II, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bela","family":"Benczur","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine (Cardiology\/Nephrology), Tolna County \u2018Balassa Janos\u2019 Teaching Hospital, Szekszard, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Ciernik","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim RCV GmbH & Co. KG, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Gotcheva","sequence":"additional","affiliation":[{"name":"Department of Cardiology, National Cardiology Hospital, Sofia, Bulgaria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8134-454X","authenticated-orcid":false,"given":"Alexey","family":"Medvedchikov","sequence":"additional","affiliation":[{"name":"Boehringer Ingelheim RCV GmbH & Co. KG, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pentti","family":"P\u00f5der","sequence":"additional","affiliation":[{"name":"Department of Cardiology, North Estonia Medical Centre Foundation, Tallinn, Estonia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dragan","family":"Simic","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Clinical Centre of Serbia, Belgrade, Serbia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andris","family":"Skride","sequence":"additional","affiliation":[{"name":"Cardiology Department, Riga Stradins University, Riga, Latvia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbo","family":"Tang","sequence":"additional","affiliation":[{"name":"Biostatistics and Data Sciences, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, Connecticut, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Trusz-Gluza","sequence":"additional","affiliation":[{"name":"First Department of Cardiology, Silesian Medical University, Katowice, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiri","family":"Vesely","sequence":"additional","affiliation":[{"name":"Faculty of Medicine in Hradec Kralov\u00e9, Charles University, Broumov, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana","family":"Vishnepolsky","sequence":"additional","affiliation":[{"name":"Clalit Health Services, Bonen Clinic, Haifa, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirej","family":"Vrabec","sequence":"additional","affiliation":[{"name":"Department of Cardiology, General Hospital Celje, Celje, Slovenia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,3,24]]},"reference":[{"key":"2025081710112121000_7.1.e001202.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2009.11.025"},{"key":"2025081710112121000_7.1.e001202.2","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/eus305"},{"key":"2025081710112121000_7.1.e001202.3","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euw295"},{"key":"2025081710112121000_7.1.e001202.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy136"},{"key":"2025081710112121000_7.1.e001202.5","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1016\/S0140-6736(17)32165-7","article-title":"A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation (IMPACT-AF): an international, cluster-randomised trial","volume":"390","author":"Vinereanu","year":"2017","journal-title":"Lancet"},{"key":"2025081710112121000_7.1.e001202.6","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euv317"},{"key":"2025081710112121000_7.1.e001202.7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0074037","article-title":"Educational intervention improves anticoagulation control in atrial fibrillation patients: the TREAT randomised trial","volume":"8","author":"Clarkesmith","year":"2013","journal-title":"PLoS One"},{"key":"2025081710112121000_7.1.e001202.8","doi-asserted-by":"crossref","DOI":"10.1186\/s12875-017-0588-2","article-title":"Does a complex intervention increase patient knowledge about oral anticoagulation? 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