{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:21:06Z","timestamp":1783074066860,"version":"3.54.6"},"reference-count":27,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T00:00:00Z","timestamp":1609977600000},"content-version":"unspecified","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006095","name":"Helse S\u00f8r-\u00d8st RHF","doi-asserted-by":"publisher","award":["2017103"],"award-info":[{"award-number":["2017103"]}],"id":[{"id":"10.13039\/501100006095","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2020,12,7]]},"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Patients with tetralogy of Fallot (TOF) have high survival rates 30 years after surgical repair. Many patients experience pregnancy; however, the effects of pregnancy on the long-term cardiovascular outcome are not well known. We investigated the association of pregnancy and cardiac function with occurrence of ventricular arrhythmia (VA) in women with TOF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We recruited 80 women with repaired TOF from the national database. Holter monitoring or implanted devices detected VA, defined as non-sustained or sustained ventricular tachycardia or aborted cardiac arrest. All patients underwent echocardiography. Blood tests included NT-proBNP (N-terminal pro-brain natriuretic peptide).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>55 (69%) women had experienced pregnancy. Mean age was lower in nulliparous compared with those with children (30\u00b19 vs 40\u00b19, p&lt;0.01).<\/jats:p>\n                  <jats:p>VA had occurred in 17 (21%) women. Prevalence of VA was higher in women who had experienced pregnancy (n=16, 94%) compared with nulliparous (n=1, 6%) (p=0.02), also when adjusted for age (OR 12.9 (95% CI 1.5 to 113.2), p=0.02).<\/jats:p>\n                  <jats:p>Right ventricular mechanical dispersion was more pronounced in patients with VA (50\u00b18 ms vs 39\u00b114 ms, p=0.01, age-adjusted OR 2.1 (95% CI 1.3 to 7.5), p=0.01). NT-proBNP was also a marker of VA (211\u2009ng\/L (127 to 836) vs 139\u2009ng\/L (30 to 465), p=0.007). NT-proBNP &gt;321\u2009ng\/L (normal values &lt;170\u2009ng\/L) detected women with VA (p=0.019), also independent of age (OR 7.2 (95% CI 1.7 to 30.1), p=0.007).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Pregnancy was associated with higher prevalence of VA among women with TOF. Right ventricular mechanical dispersion and NT-proBNP were age-independent markers of VA. These may have importance for pregnancy counselling and risk stratification.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2020-001400","type":"journal-article","created":{"date-parts":[[2021,1,7]],"date-time":"2021-01-07T13:52:56Z","timestamp":1610027576000},"page":"e001400","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Impact of pregnancy and risk factors for ventricular arrhythmias in women with tetralogy of Fallot"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8915-2630","authenticated-orcid":false,"given":"Alessia","family":"Quattrone","sequence":"first","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Oslo, Norway"},{"name":"University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oyvind H","family":"Lie","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Oslo, Norway"},{"name":"University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eirik","family":"Nestaas","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Vestfold Hospital Trust, T\u00f8nsberg, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"de Lange","sequence":"additional","affiliation":[{"name":"Division of Radiology and Nuclear Medicine, Section of Pediatric Radiology, Oslo University Hospital, Oslo, Norway"},{"name":"Sahlgrenska University Hospital, Goteborg, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsti","family":"Try","sequence":"additional","affiliation":[{"name":"Division of Radiology and Nuclear Medicine, Section of Pediatric Radiology, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald L","family":"Lindberg","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Surgery, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Skulstad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Oslo, Norway"},{"name":"University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnar","family":"Erikssen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thor","family":"Edvardsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Oslo, Norway"},{"name":"University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4900-0453","authenticated-orcid":false,"given":"Kristina","family":"Haugaa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Oslo, Norway"},{"name":"University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette E","family":"Estensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Oslo University Hospital, Oslo, Norway"},{"name":"University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,1,7]]},"reference":[{"key":"2025081710095964000_8.1.e001400.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(97)00318-5"},{"key":"2025081710095964000_8.1.e001400.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.12.065"},{"key":"2025081710095964000_8.1.e001400.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009454"},{"key":"2025081710095964000_8.1.e001400.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02714-8"},{"key":"2025081710095964000_8.1.e001400.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2019.03.014"},{"key":"2025081710095964000_8.1.e001400.6","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.009029"},{"key":"2025081710095964000_8.1.e001400.7","doi-asserted-by":"publisher","DOI":"10.1002\/uog.12296"},{"key":"2025081710095964000_8.1.e001400.8","doi-asserted-by":"publisher","DOI":"10.1038\/ajh.2012.29"},{"key":"2025081710095964000_8.1.e001400.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2010.10.027"},{"key":"2025081710095964000_8.1.e001400.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2003.11.067"},{"key":"2025081710095964000_8.1.e001400.11","doi-asserted-by":"publisher","DOI":"10.1093\/europace\/euu194"},{"key":"2025081710095964000_8.1.e001400.12","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/j.1542-474X.2004.93003.x","article-title":"Exercising testing in adult normal subjects and cardiac patients. 1963","volume":"9","author":"Bruce","year":"2004","journal-title":"Ann Noninvasive Electrocardiol"},{"key":"2025081710095964000_8.1.e001400.13","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev139"},{"key":"2025081710095964000_8.1.e001400.14","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jev014"},{"key":"2025081710095964000_8.1.e001400.15","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2009.184390"},{"key":"2025081710095964000_8.1.e001400.16","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr069"},{"key":"2025081710095964000_8.1.e001400.17","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jew229"},{"key":"2025081710095964000_8.1.e001400.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2015.09.046"},{"key":"2025081710095964000_8.1.e001400.19","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.116.005420"},{"key":"2025081710095964000_8.1.e001400.20","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2012.12.071"},{"key":"2025081710095964000_8.1.e001400.21","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2009.11.012"},{"key":"2025081710095964000_8.1.e001400.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2013.03.005"},{"key":"2025081710095964000_8.1.e001400.23","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.05.017"},{"key":"2025081710095964000_8.1.e001400.24","doi-asserted-by":"publisher","DOI":"10.1093\/ejechocard\/jeq067"},{"key":"2025081710095964000_8.1.e001400.25","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2018.03.012"},{"key":"2025081710095964000_8.1.e001400.26","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2016.06.011"},{"key":"2025081710095964000_8.1.e001400.27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.02.092"}],"updated-by":[{"DOI":"10.1136\/openhrt-2020-001400corr1","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000}}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2020-001400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T17:10:07Z","timestamp":1755450607000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2020-001400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":27,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,1,7]]},"published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1136\/openhrt-2020-001400"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2020-001400","relation":{"correction":[{"id-type":"doi","id":"10.1136\/openhrt-2020-001400corr1","asserted-by":"object"}]},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,1]]}}}