{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:33:50Z","timestamp":1772580830280,"version":"3.50.1"},"reference-count":30,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T00:00:00Z","timestamp":1602547200000},"content-version":"unspecified","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2020,9,3]]},"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>A small proportion of patients undergoing bicuspid aortic valve (BAV) intervention have had prior repair of aortic coarctation (CoA). We aimed to describe phenotypic differences between BAV patients, comparing those with versus those without previous coarctation repair.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>556 adults with BAV who had undergone aortic valve and\/or ascending aortic surgery were identified, and relevant clinical and operative details were retrospectively analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the total cohort, 532 patients (95.7%) had isolated BAV (\u2018BAV-only\u2019), and 24 (4.3%) had had a previous successful CoA repair (\u2018BAV-CoA\u2019). The median age at surgery was significantly lower in BAV-CoA patients compared with BAV-only (median, IQR: 40\u2009years, 26\u201357 vs 62\u2009years, 51\u201369, p&lt;0.001). Indications for surgery also differed, with BAV-CoA patients much more likely to undergo surgery for aortic regurgitation (BAV-CoA 38% vs BAV-only 13%, p&lt;0.001); patients with isolated BAV were more likely to require surgery for aortic stenosis (BAV-only 75% vs BAV-CoA 50%, p&lt;0.001). Two different BAV morphotypes were commoner in the BAV-CoA group; type 0 valves (24% vs 8%, p&lt;0.05) and type 2 valves (12% vs 3%, p&lt;0.05). The proportion of patients undergoing concomitant aortic surgery at the time of valve surgery were similar (BAV-only 38% vs BAV-CoA 42%, p=0.8).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In adult patients undergoing aortic valve surgery for BAV disease, those with a prior history of repaired CoA underwent surgery at a very much younger age, and a higher proportion required intervention for aortic regurgitation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2020-001429","type":"journal-article","created":{"date-parts":[[2020,10,13]],"date-time":"2020-10-13T17:06:28Z","timestamp":1602608788000},"page":"e001429","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Bicuspid aortic valve: different clinical profiles for subjects with versus without repaired aortic coarctation"],"prefix":"10.1136","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6416-5566","authenticated-orcid":false,"given":"Michelle S","family":"Lim","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Cardiology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul G","family":"Bannon","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Cardiothoracic Surgery, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S","family":"Celermajer","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia"},{"name":"Cardiology, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2020,10,13]]},"reference":[{"key":"2025081611555028000_7.2.e001429.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8703(28)90281-1"},{"key":"2025081611555028000_7.2.e001429.2","doi-asserted-by":"crossref","first-page":"S347","DOI":"10.1016\/j.hlc.2019.06.496","article-title":"Bicuspid aortic valve disease \u2013 valve morphotype influences age at and indications for operative treatment","volume":"28","author":"Lim","year":"2019","journal-title":"Heart, Lung and 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