{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:49:48Z","timestamp":1755794988134,"version":"3.44.0"},"reference-count":26,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,5,16]],"date-time":"2021-05-16T00:00:00Z","timestamp":1621123200000},"content-version":"unspecified","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CIBERCV16\/11\/00486","PI20\/00637"],"award-info":[{"award-number":["CIBERCV16\/11\/00486","PI20\/00637"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2021,4,30]]},"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We assessed the influence of the ischaemic burden (IB) as derived from vasodilator stress cardiovascular magnetic resonance (CMR) on the risk of death and the effect of revascularisation across sex.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We evaluated 6237 consecutive patients with known or suspected chronic coronary syndrome (CCS). Extensive ischaemia was defined as &gt;5 segments with perfusion deficit. Multivariate Cox proportional hazard regression models were used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 2371 (38.0%) patients were women and 583 (9.3%) underwent CMR-related revascularisation. During a median follow-up of 5.13 years, 687 (11.0%) deaths were reported. We found an adjusted differential effect of CMR-derived IB across sex (p value for interaction=0.039). Women exhibited an adjusted lower risk of death and only equaled men\u2019s risk when extensive ischaemia was present. Likewise, CMR-related revascularisation was shown to be differentially associated with the risk of mortality across sex (p value for interaction=0.025). In patients with non-extensive ischaemia, revascularisation was associated with a higher risk of death, with a greater extent in women. At higher IB, revascularisation was associated with a lower risk in men, with more uncertain results in women.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CMR-derived IB allows predicting the risk of death and gives insight into the potential effect of revascularisation in men and women with CCS. Compared with men, women with non-extensive ischaemia displayed a lower risk and a similar risk with a higher IB. The impact of CMR-related revascularisation on mortality risk was also significantly different according to IB and sex. Further research will be needed to confirm these hypothesis-generating findings.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2021-001619","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T13:07:12Z","timestamp":1621256832000},"page":"e001619","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Sex differences in mortality in stable patients undergoing vasodilator stress cardiovascular magnetic resonance"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8777-2588","authenticated-orcid":false,"given":"Gema","family":"Mi\u00f1ana","sequence":"first","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose V","family":"Monmeneu","sequence":"additional","affiliation":[{"name":"Cardiac Imaging Unit, ERESA, Unidad de Imagen Cardiaca Valencia, ES, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria P","family":"L\u00f3pez-Lereu","sequence":"additional","affiliation":[{"name":"Cardiac Imaging Unit, ERESA, Unidad de Imagen Cardiaca Valencia, ES, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose","family":"Gavara","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5565-5547","authenticated-orcid":false,"given":"V\u00edctor","family":"Marcos-Garc\u00e9s","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesar","family":"R\u00edos-Navarro","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nerea","family":"P\u00e9rez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"de Dios","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Fern\u00e1ndez-Cisnal","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco J","family":"Chorro","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Sanchis","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicente","family":"Bodi","sequence":"additional","affiliation":[{"name":"Cardiology Department, Hospital Clinico Universitario, Valencia, 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