{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T12:59:20Z","timestamp":1789563560843,"version":"build-2803163510"},"reference-count":20,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005633","name":"Syd\u00e4ntutkimuss\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010133","name":"Aarne Koskelon S\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010133","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Special Government Subsidy","award":["Y2019SK005 and TYH2014208"],"award-info":[{"award-number":["Y2019SK005 and TYH2014208"]}]},{"name":"Government Research Funding"},{"name":"Helsinki University Library"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2021,4,6]]},"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:sec>\n                  <jats:title>Aims<\/jats:title>\n                  <jats:p>\n                     <jats:italic>LMNA-<\/jats:italic>cardiomyopathy is often associated with pathology in the cardiac conduction system necessitating device implantations. The aim was to study the timing and types of device implantations and need for re-implantations in <jats:italic>LMNA<\/jats:italic> mutation carriers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We studied the hospital records of 60 <jats:italic>LMNA<\/jats:italic> mutation carriers concerning device implantations and re-implantations and their indications. Data were collected until April 2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The median follow-up time from the first ECG recording to the last clinical follow-up, transplantation, or death was 7.7 (IQR=9.1) years. Altogether 61.7% (n=37) of the <jats:italic>LMNA<\/jats:italic> mutation carriers received a pacemaker or an implantable cardioverter defibrillator (ICD), and of them 27.0% (n=10) needed a device upgrade. Notably, in some patients the upgrade took place very soon after the first implantation. The first device was implanted at an average age of 47.9 years (SD=9.5), whereas the upgrade took place at an average age of 50.3 years (SD=8.1). Most upgrades were ICD implantations. Male patients underwent device upgrade more often and at a younger age than women. By the end of follow-up, 35.0% (n=21) of the patients fulfilled echocardiographic criteria for dilated cardiomyopathy, and 90.5% of them (n=19) needed pacemaker implantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Most <jats:italic>LMNA<\/jats:italic> mutation carriers underwent pacemaker implantation in this study. Due to the progressive nature of <jats:italic>LMNA<\/jats:italic>-cardiomyopathy, device upgrades are quite common. An ICD should be considered when the initial device implantation is planned in an <jats:italic>LMNA<\/jats:italic> mutation carrier.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2021-001622","type":"journal-article","created":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T10:37:47Z","timestamp":1619174267000},"page":"e001622","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Timing of pacemaker and ICD implantation in <i>LMNA<\/i> mutation carriers"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4406-6119","authenticated-orcid":false,"given":"Laura Helena","family":"Ollila","sequence":"first","affiliation":[{"name":"Heart and Lung Centre, Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kjell","family":"Nikus","sequence":"additional","affiliation":[{"name":"Heart Centre, Tampere University Hospital, Tampere, Finland"},{"name":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannu","family":"Parikka","sequence":"additional","affiliation":[{"name":"Heart and Lung Centre, Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sini","family":"Weckstr\u00f6m","sequence":"additional","affiliation":[{"name":"Heart and Lung Centre, Helsinki University Central Hospital, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heli\u00f6","family":"Tiina","sequence":"additional","affiliation":[{"name":"Heart and Lung Centre, Helsinki University Central Hospital, Helsinki, Finland"},{"name":"University of Helsinki, Helsinki, Finland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,4,23]]},"reference":[{"key":"2025081612112138000_8.1.e001622.1","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1080\/19491034.2016.1260798","article-title":"Current insights into LMNA cardiomyopathies: existing models and missing LINCs","volume":"8","author":"Brayson","year":"2017","journal-title":"Nucleus"},{"key":"2025081612112138000_8.1.e001622.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.11.066"},{"key":"2025081612112138000_8.1.e001622.3","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-004-0589-1"},{"key":"2025081612112138000_8.1.e001622.4","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9051443","article-title":"Can Circulating Cardiac Biomarkers Be Helpful in the Assessment of LMNA Mutation Carriers?","volume":"9","author":"Chmielewski","year":"2020","journal-title":"J Clin Med"},{"key":"2025081612112138000_8.1.e001622.5","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1080\/19491034.2018.1489195","article-title":"Updated clinical overview on cardiac laminopathies: an electrical and mechanical disease","volume":"9","author":"Peretto","year":"2018","journal-title":"Nucleus"},{"key":"2025081612112138000_8.1.e001622.6","doi-asserted-by":"publisher","DOI":"10.1097\/GIM.0b013e3181f2481f"},{"key":"2025081612112138000_8.1.e001622.7","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehr451"},{"key":"2025081612112138000_8.1.e001622.8","doi-asserted-by":"crossref","unstructured":"Ollila L , Kuusisto J , Peuhkurinen K , et al . Lamin A\/C mutation affecting primarily the right side of the heart. Cardiogenetics 2013;3.doi:10.4081\/cardiogenetics.2013.e1","DOI":"10.4081\/cardiogenetics.2013.e1"},{"key":"2025081612112138000_8.1.e001622.9","doi-asserted-by":"publisher","DOI":"10.1186\/1532-429X-13-30"},{"key":"2025081612112138000_8.1.e001622.10","doi-asserted-by":"publisher","DOI":"10.1080\/10976640701693733"},{"key":"2025081612112138000_8.1.e001622.11","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCEP.116.004357","article-title":"Multicenter experience with catheter ablation for ventricular tachycardia in lamin A\/C cardiomyopathy","volume":"9","author":"Kumar","year":"2016","journal-title":"Circ Arrhythm Electrophysiol"},{"key":"2025081612112138000_8.1.e001622.12","doi-asserted-by":"publisher","DOI":"10.1136\/openhrt-2016-000474"},{"key":"2025081612112138000_8.1.e001622.13","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv316"},{"key":"2025081612112138000_8.1.e001622.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.08.078"},{"key":"2025081612112138000_8.1.e001622.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ehj.2004.01.020"},{"key":"2025081612112138000_8.1.e001622.16","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.2004.056721"},{"key":"2025081612112138000_8.1.e001622.17","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(92)90901-A"},{"key":"2025081612112138000_8.1.e001622.18","doi-asserted-by":"publisher","DOI":"10.1016\/j.hrthm.2013.06.020"},{"key":"2025081612112138000_8.1.e001622.19","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/eht511"},{"key":"2025081612112138000_8.1.e001622.20","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.19102\/icrm.2016.070003","article-title":"How to define cardiac resynchronization therapy response","volume":"7","author":"Tomassoni","year":"2016","journal-title":"J Innov Card Rhythm Manag"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2021-001622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,16]],"date-time":"2025-08-16T19:11:27Z","timestamp":1755371487000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2021-001622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,4,23]]},"published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1136\/openhrt-2021-001622"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2021-001622","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}