{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:22:25Z","timestamp":1793380945286,"version":"4.5.0"},"reference-count":46,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2021,6,2]],"date-time":"2021-06-02T00:00:00Z","timestamp":1622592000000},"content-version":"unspecified","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2021,5,14]]},"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The COVID-19 pandemic has disrupted healthcare systems across the world. The rate of acute coronary syndrome (ACS) admissions during the pandemic has varied significantly.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The purpose of this study is to investigate the effect of the pandemic on ACS hospital admissions and to determine whether this is related to the number of COVID-19 cases in each country.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Search engines including PubMed, Embase, Ovid and Google Scholar were searched from December 2019 to the 15 September 2020 to identify studies reporting ACS admission data during COVID-19 pandemic months in 2020 compared with 2019 admissions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 40 studies were included in this multistudy analysis. They demonstrated a 28.1% reduction in the rate of admission with ACS during the COVID-19 pandemic period compared with the same period in 2019 (total of 28 613 patients in 2020 vs 39 225 in 2019). There was a significant correlation between the absolute risk reduction in the total number of ACS cases and the number of COVID-19 cases per 100 000 population (Pearson correlation=0.361 (p=0.028)). However, the correlation was not significant for each of the ACS subgroups: non-ST-elevation myocardial infarction (STEMI) (p=0.508), STEMI (p=0883) and unstable angina (p=0.175).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was a significant reduction in the rate of ACS admission during the COVID-19 pandemic period compared with the same period in 2019 with a significant correlation with COVID-19 prevalence.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2021-001645","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T02:20:00Z","timestamp":1622686800000},"page":"e001645","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":31,"title":["Global effect of COVID-19 pandemic on the rate of acute coronary syndrome admissions: a comprehensive review of published literature"],"prefix":"10.1136","volume":"8","author":[{"given":"Ayman","family":"Helal","sequence":"first","affiliation":[{"name":"Cardiology Department, Portsmouth Hospital NHS Trust, Portsmouth, UK"},{"name":"Cardiology Department, Fayoum University, Fayoum, Portsmouth, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lamis","family":"Shahin","sequence":"additional","affiliation":[{"name":"Fellowship Program, Cardiology Department, Ministry of Health and Population, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmoud","family":"Abdelsalam","sequence":"additional","affiliation":[{"name":"Cardiology Department, Conemaugh Memorial Medical Center, Johnstown, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0107-4146","authenticated-orcid":false,"given":"Mokhtar","family":"Ibrahim","sequence":"additional","affiliation":[{"name":"Cardiology Department, University Hospitals of Leicester NHS Trust, Leicester, Leicester, UK"},{"name":"Cardiology Department, Ain Shams University, Cairo, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2021,6,2]]},"reference":[{"key":"2025081709401448000_8.1.e001645.1","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/bjs.11627","article-title":"COVID-19 pandemic: perspectives on an unfolding crisis","volume":"107","author":"Spinelli","year":"2020","journal-title":"Br J Surg"},{"key":"2025081709401448000_8.1.e001645.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30690-5"},{"key":"2025081709401448000_8.1.e001645.3","doi-asserted-by":"crossref","first-page":"1545-1546","DOI":"10.1001\/jama.2020.4031","article-title":"Critical care utilization for the COVID-19 outbreak in Lombardy, Italy: early experience and forecast during an emergency response","volume":"323","author":"Grasselli","year":"2020","journal-title":"JAMA"},{"key":"2025081709401448000_8.1.e001645.4","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehaa314"},{"key":"2025081709401448000_8.1.e001645.5","unstructured":"Wood S . The mystery of the missing STEMIs during the COVID-19 pandemic, 2020. 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Comparison of the number of cardiovascular admissions before and after COVID-19: experience from turkey, 2020. 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