{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T08:17:13Z","timestamp":1791274633635,"version":"4.1.0"},"reference-count":31,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2021,9,27]],"date-time":"2021-09-27T00:00:00Z","timestamp":1632700800000},"content-version":"unspecified","delay-in-days":26,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"The\n                                    Japan Society for the Promotion of\n                                    Science","doi-asserted-by":"crossref","award":["KAKENHI\n                                    # 20K08042 (NOM)"],"award-info":[{"award-number":["KAKENHI\n                                    # 20K08042 (NOM)"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:sec>\n                        <jats:title>Objective<\/jats:title>\n                        <jats:p>We investigated the diagnostic performance of semi-quantitative\n                            hyperintensity on T2-weighted short-tau-inversion-recovery black-blood\n                            (T2W-STIR-BB) images in identifying active cardiac sarcoidosis (CS) in\n                            patients, and compared it with that\n                            of<jats:sup>18<\/jats:sup>F-fluoro-2-deoxyglucose positron emission\n                            tomography (FDG-PET).<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                        <jats:title>Methods<\/jats:title>\n                        <jats:p>This retrospective study included 40 steroid-naive patients (age\n                            63.1\u00b112.9 years, 20 men) diagnosed with CS who underwent both cardiac\n                            MRI and FDG-PET imaging. Active CS cases were defined as satisfying at\n                            least one of the following criteria for conventional indices:\n                            exacerbation of ventricular arrhythmia, newly identified advanced\n                            atrioventricular block, greater than 5% decrease in left ventricular\n                            ejection fraction on echocardiography, positive finding on\n                            gallium-scintigraphy or elevated levels of sarcoidosis-related serum\n                            biomarkers. T2W-STIR-BB images were semi-quantitatively analysed using a\n                            myocardium-to-spleen ratio (MSR). The diagnostic performance of\n                            T2W-STIR-BB and FDG-PET imaging for detecting active CS was\n                            investigated.<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                        <jats:title>Results<\/jats:title>\n                        <jats:p>Thirty-three patients satisfied at least one criterion and were\n                            considered as having active CS. Thirty patients (75%) tested positive\n                            with T2W-STIR-BB imaging, and 25 patients (63%) tested positive with\n                            FDG-PET. The sensitivity, specificity, accuracy, and positive and\n                            negative predictive values for identifying active CS by\n                            semi-quantitative MSR on T2W-STIR-BB images were 79%, 43%, 73%, 87% and\n                            30%, respectively. These results were statistically comparable to those\n                            of FDG-PET (70%, 71%, 70%, 92% and 33%, respectively).<\/jats:p>\n                    <\/jats:sec>\n                    <jats:sec>\n                        <jats:title>Conclusions<\/jats:title>\n                        <jats:p>When using conventional diagnostic indices for active CS as the gold\n                            standard, T2W-STIR-BB imaging demonstrated comparable diagnostic\n                            performance to that of FDG-PET. The semi-quantitative analysis of high\n                            signal intensity on T2W-STIR-BB images using MSR was useful for\n                            detection of active CS.<\/jats:p>\n                    <\/jats:sec>","DOI":"10.1136\/openhrt-2021-001728","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T12:37:43Z","timestamp":1667911063000},"page":"e001728","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":15,"title":["T2-weighted short-tau-inversion-recovery imaging reflects disease\n                        activity of cardiac sarcoidosis"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7998-939X","authenticated-orcid":false,"given":"Reina","family":"Tonegawa-Kuji","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0394-6390","authenticated-orcid":false,"given":"Noriko","family":"Oyama-Manabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Aoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Nagayoshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian Michael 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