{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:56:34Z","timestamp":1771548994059,"version":"3.50.1"},"reference-count":17,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2021,10,10]],"date-time":"2021-10-10T00:00:00Z","timestamp":1633824000000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Royal Baggot Street Trust"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2021,9,27]]},"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Incomplete cardiac revascularisation (ICR) assessed by residual SYNTAX score (rSs) is associated with increased 5-year mortality. Furthermore, in the general population, our group has demonstrated that impaired autonomic function determined by heart rate recovery time between 10 and 20\u2009s (HRR<jats:sub>10\u201320<\/jats:sub>) following an active stand is associated with increased all-cause mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>We hypothesised that ICR would be associated with impaired autonomic function determined by HRR<jats:sub>10\u201320<\/jats:sub>.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>After ethical approval and informed consent, consecutive patients attending cardiac rehabilitation in a tertiary referral centre were enrolled. All patients had percutaneous coronary revascularisation. During an active stand, real-time heart rate, blood pressure and ECG recordings were taken using non-invasive digital photoplethysmography and HRR<jats:sub>10\u201320<\/jats:sub> determined. Assessment of autonomic function was performed by determining speed of HRR<jats:sub>10\u201320<\/jats:sub> post-orthostatic challenge.<\/jats:p>\n                  <jats:p>Patients with an rSs &gt;0 were considered incompletely revascularised and those with an rSs of 0 fully revascularised. Demographic data were recorded and statistical analysis performed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Patients (n=53) comprised those with complete revascularisation (CR) (n=37) and ICR (n=16). In the ICR group, mean rSs was 9.4.<\/jats:p>\n                  <jats:p>HRR<jats:sub>10\u201320<\/jats:sub> was impaired in the ICR group (\u22123\u00b10.60) compared with the CR cohort (\u22126.56\u00b10.52) (p&lt;0.0001). Completeness of revascularisation was strongly associated with HRR<jats:sub>10\u201320<\/jats:sub> (Pearson\u2019s correlation coefficient 0.529; p&lt;0.0001). Baseline demographics did not differ significantly. Use of rate-limiting medication was similar between cohorts (beta blockers, calcium channel blockers, ivabradine).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our data confirm significant correlation between ICR and impaired autonomic function determined by speed of heart rate recovery. Thus, determining autonomic dysfunction post-ICR may identify those at increased mortality risk.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2021-001835","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T14:16:42Z","timestamp":1633961802000},"page":"e001835","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Impaired autonomic function after incomplete revascularisation"],"prefix":"10.1136","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6698-8109","authenticated-orcid":false,"given":"Richard","family":"Armstrong","sequence":"first","affiliation":[{"name":"Cardiology, Belfast Health and Social Care Trust, Belfast, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-471X","authenticated-orcid":false,"given":"Peter","family":"Wheen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St James Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Brandon","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St James Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ciar\u00e1n","family":"Finucane","sequence":"additional","affiliation":[{"name":"TILDA Medical Gerontology, Trinity College, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rose Anne","family":"Kenny","sequence":"additional","affiliation":[{"name":"TILDA Medical Gerontology, Trinity College, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Maree","sequence":"additional","affiliation":[{"name":"Department of Cardiology, St James Hospital, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"2025081612191145000_8.2.e001835.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199910283411804"},{"key":"2025081612191145000_8.2.e001835.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(02)02706-6"},{"key":"2025081612191145000_8.2.e001835.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.10.039"},{"key":"2025081612191145000_8.2.e001835.4","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.308577"},{"key":"2025081612191145000_8.2.e001835.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)11144-8"},{"key":"2025081612191145000_8.2.e001835.6","doi-asserted-by":"publisher","DOI":"10.1007\/BF01824992"},{"key":"2025081612191145000_8.2.e001835.7","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000117090.01718.2A"},{"key":"2025081612191145000_8.2.e001835.8","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.084236"},{"key":"2025081612191145000_8.2.e001835.9","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1305520"},{"key":"2025081612191145000_8.2.e001835.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2014.12.038"},{"key":"2025081612191145000_8.2.e001835.11","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)60648-1"},{"key":"2025081612191145000_8.2.e001835.12","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.001803"},{"key":"2025081612191145000_8.2.e001835.13","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00873-5"},{"key":"2025081612191145000_8.2.e001835.14","first-page":"695","article-title":"[Heart 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