{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:40:14Z","timestamp":1792798814456,"version":"4.5.0"},"reference-count":23,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T00:00:00Z","timestamp":1642723200000},"content-version":"unspecified","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010306","name":"Direkt\u00f8r Kurt B\u00f8nnelycke og Hustru fru Grethe B\u00f8nnelyckes Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010306","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ove William Buhl Olesen"},{"DOI":"10.13039\/501100005860","name":"Helsefonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005860","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Odense University Hospital","id":[{"id":"https:\/\/ror.org\/00ey0ed83","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2022,1,4]]},"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To describe the occurrence of significant pericardial effusion, and to investigate characteristics associated with pericardial effusion within three months following heart valve surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective, observational cohort study including adult patients undergoing heart valve surgery at Odense University Hospital from August 2013 to November 2017. Data were gathered from The Western Denmark Heart Registry and electronic patient records.<\/jats:p>\n                    <jats:p>Cox proportional hazard models were used to investigate the associations between characteristics associated with significant pericardial effusion during index admission and within 3\u2009months. Results are presented as HR with 95% CI.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total, 1460 patients were included (70% men, median age 71 years (IQR 63\u201376)) and of those, n=230 patients (16%) developed significant pericardial effusion.<\/jats:p>\n                    <jats:p>EuroScore II was significantly associated with an increased risk of pericardial effusion during index admission and associated with a lower risk following discharge (index admission HR 1.05, 95%\u2009CI 1.02 to 1.08, after discharge HR 0.80, 95%\u2009CI 0.69 to 0.92). Increasing age (HR 0.97, 95%\u2009CI 0.95 to 0.98 per year) and concomitant coronary artery bypass grafting versus isolated valve surgery (HR 0.58, 95%\u2009CI 0.35 to 0.97) were significantly associated with a reduced risk of pericardial effusions in both periods. Being a man (HR 2.30, 95%\u2009CI 1.32 to 4.01) and aortic valve disease versus mitral valve disease (HR 2.16, 95%\u2009CI 1.20 to 3.90) were significantly associated with an increased risk after discharge.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Significant pericardial effusions requiring drainage were present in 16% of cases following heart valve surgery, and different clinical characteristics were associated with the development of effusion.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2021-001880","type":"journal-article","created":{"date-parts":[[2022,1,21]],"date-time":"2022-01-21T10:16:24Z","timestamp":1642760184000},"page":"e001880","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Occurrence and predictors of pericardial effusion requiring invasive treatment following heart valve surgery"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2702-0231","authenticated-orcid":false,"given":"Britt","family":"Borregaard","sequence":"first","affiliation":[{"name":"Department of Cardiology, Odense Universitetshospital, Odense, Denmark"},{"name":"Department of Cardiac, Thoracic and Vascular Surgery, Odense Universitetshospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3387-7971","authenticated-orcid":false,"given":"Kirstine L\u00e6rum","family":"Sibilitz","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc Gjern","family":"Weiss","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Surgery, Odense Universitetshospital, Odense, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ola","family":"Ekholm","sequence":"additional","affiliation":[{"name":"National Institute of Public Health, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie Karense","family":"Lykking","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Surgery, Odense Universitetshospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stine N\u00f8rris","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense Universitetshospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Peter","family":"Riber","sequence":"additional","affiliation":[{"name":"Department of Cardiac, Thoracic and Vascular Surgery, Odense Universitetshospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi Sanchez","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense Universitetshospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob Eifer","family":"Moller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense Universitetshospital, Odense, Denmark"},{"name":"Department of Clinical Research, University of Southern Denmark, Odense, Denmark"},{"name":"Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,1,21]]},"reference":[{"key":"2025081710004165000_9.1.e001880.1","doi-asserted-by":"publisher","DOI":"10.1136\/hrt.72.4.327"},{"key":"2025081710004165000_9.1.e001880.2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0165754","article-title":"Incidence, predictors, and clinical outcomes of postoperative cardiac tamponade in patients undergoing heart valve surgery","volume":"11","author":"You","year":"2016","journal-title":"PLoS One"},{"key":"2025081710004165000_9.1.e001880.3","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv318"},{"key":"2025081710004165000_9.1.e001880.4","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1093\/icvts\/ivx011","article-title":"Incidence, presentation and risk factors of late postoperative pericardial effusions requiring invasive treatment after 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A single-center experience","volume":"26","author":"Nguyen","year":"2018","journal-title":"Asian Cardiovasc Thorac Ann"},{"key":"2025081710004165000_9.1.e001880.9","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4103\/aca.ACA_147_17","article-title":"Factors associated with delayed cardiac tamponade after cardiac surgery","volume":"21","author":"Leiva","year":"2018","journal-title":"Ann Card Anaesth"},{"key":"2025081710004165000_9.1.e001880.10","doi-asserted-by":"crossref","first-page":"31957","DOI":"10.3402\/jchimp.v6.31957","article-title":"Effects of colchicine on pericardial diseases: a review of the literature and current evidence","volume":"6","author":"Shah","year":"2016","journal-title":"J Community Hosp Intern Med Perspect"},{"key":"2025081710004165000_9.1.e001880.11","doi-asserted-by":"crossref","DOI":"10.1186\/s12872-019-1190-4","article-title":"Meta-Analysis for the value of colchicine for the therapy of pericarditis and of postpericardiotomy syndrome","volume":"19","author":"Lutschinger","year":"2019","journal-title":"BMC Cardiovasc Disord"},{"key":"2025081710004165000_9.1.e001880.12","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62709-9"},{"key":"2025081710004165000_9.1.e001880.13","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2015-307827"},{"key":"2025081710004165000_9.1.e001880.14","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1016\/j.ahj.2015.09.020","article-title":"Efficacy of colchicine versus placebo for the treatment of pericardial effusion after open-heart surgery: a randomized, placebo-controlled trial","volume":"170","author":"Izadi Amoli","year":"2015","journal-title":"Am Heart J"},{"key":"2025081710004165000_9.1.e001880.15","unstructured":"Committee NM-S . 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