{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T08:10:35Z","timestamp":1777363835884,"version":"3.51.4"},"reference-count":34,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"unspecified","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Abbott Medical UK Ltd"},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011699","name":"Siemens Healthineers","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011699","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/19\/48\/34523"],"award-info":[{"award-number":["FS\/19\/48\/34523"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001316","name":"Abbott Laboratories","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001316","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011949","name":"Abbott Vascular","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100011949","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2022,6,6]]},"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study evaluates predictors of conduction abnormalities (CA) following transcatheter aortic valve implantation (TAVI) in patients with bicuspid aortic valves (BAV).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>TAVI is associated with CA that commonly necessitate a permanent pacemaker. Predictors of CA are well established among patients with tricuspid aortic valves but not in those with BAV.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This is a single-centre, retrospective, observational study of patients with BAV treated with TAVI. Pre-TAVI ECG and CT scans and procedural characteristics were evaluated in 58 patients with BAV. CA were defined as a composite of high-degree atrioventricular block, new left bundle branch block with a QRS &gt;150\u2009ms or PR &gt;240\u2009ms and right bundle branch block with new PR prolongation or change in axis. Predictors of CA were identified using regression analysis and optimum cut-off values determined using area under the receiver operating characteristic curve analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>CA occurred in 35% of patients. Bioprosthesis implantation depth, the difference between membranous septum (MS) length and implantation depth (<jats:bold>\u03b4<\/jats:bold>MSID) and device landing zone (DLZ) calcification adjacent to the MS were identified as univariate predictors of CA. The optimum cut-off for <jats:bold>\u03b4<\/jats:bold>MSID was 1.25\u2009mm. Using this cut-off, low <jats:bold>\u03b4<\/jats:bold>MSID and DLZ calcification adjacent to MS predicted CA, adjusted OR 8.79, 95% CI 1.88 to 41.00; p=0.01. Eccentricity of the aortic valve annulus, type of BAV and valve calcium quantity and distribution did not predict CA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In BAV patients undergoing TAVI, short <jats:bold>\u03b4<\/jats:bold>MSID and DLZ calcification adjacent to MS are associated with an increased risk of CA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2022-001995","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T12:19:49Z","timestamp":1657023589000},"page":"e001995","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Predictors of post-TAVI conduction abnormalities in patients with bicuspid aortic valves"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5387-0147","authenticated-orcid":false,"given":"Giulia","family":"Esposito","sequence":"first","affiliation":[{"name":"King's College London Faculty of Life Sciences and Medicine, London, UK"},{"name":"Cardiology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niraj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Cardiology, Barts Health NHS Trust, London, UK"},{"name":"University College London Institute of Cardiovascular Science, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Pugliese","sequence":"additional","affiliation":[{"name":"Cardiology, Barts Health NHS Trust, London, UK"},{"name":"Centre for Advanced Cardiovascular Imaging, Queen Mary University William Harvey Research Institute, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Max","family":"Sayers","sequence":"additional","affiliation":[{"name":"Cardiology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony WC","family":"Chow","sequence":"additional","affiliation":[{"name":"Cardiology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Kennon","sequence":"additional","affiliation":[{"name":"Cardiology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mick","family":"Ozkor","sequence":"additional","affiliation":[{"name":"Cardiology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Mathur","sequence":"additional","affiliation":[{"name":"Barts Health NHS Trust, London, UK"},{"name":"Centre for Cardiovascular Medicine and Devices, Queen Mary University William Harvey Research Institute, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Baumbach","sequence":"additional","affiliation":[{"name":"Centre for Cardiovascular Medicine and Devices, Queen Mary University William Harvey Research Institute, London, UK"},{"name":"Barts Heart Centre, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guy","family":"Lloyd","sequence":"additional","affiliation":[{"name":"Cardiology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aigerim","family":"Mullen","sequence":"additional","affiliation":[{"name":"University College London Institute of Cardiovascular Science, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Cook","sequence":"additional","affiliation":[{"name":"University College London Institute of Cardiovascular Science, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4911-3511","authenticated-orcid":false,"given":"Michael","family":"Mullen","sequence":"additional","affiliation":[{"name":"Cardiology, Barts Health NHS Trust, London, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kush P","family":"Patel","sequence":"additional","affiliation":[{"name":"Cardiology, Barts Health NHS Trust, London, UK"},{"name":"University College London Institute of Cardiovascular Science, London, 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