{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T02:22:08Z","timestamp":1782267728458,"version":"3.54.5"},"reference-count":20,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T00:00:00Z","timestamp":1655769600000},"content-version":"unspecified","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004411","name":"Heart and Stroke Foundation of Canada","doi-asserted-by":"publisher","award":["New National Investigator Award"],"award-info":[{"award-number":["New National Investigator Award"]}],"id":[{"id":"10.13039\/100004411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["399323"],"award-info":[{"award-number":["399323"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Institute of Health","award":["R01 HL136431"],"award-info":[{"award-number":["R01 HL136431"]}]},{"name":"National Institute of Health","award":["R01 HL141917"],"award-info":[{"award-number":["R01 HL141917"]}]},{"name":"National Institute of Health","award":["R01 HL147095"],"award-info":[{"award-number":["R01 HL147095"]}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["Chercheur-boursier clinicien"],"award-info":[{"award-number":["Chercheur-boursier clinicien"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["Programme de formation pour les m\u00e9decins r\u00e9siden"],"award-info":[{"award-number":["Programme de formation pour les m\u00e9decins r\u00e9siden"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["Canada Graduate Scholarship - Master's Program"],"award-info":[{"award-number":["Canada Graduate Scholarship - Master's Program"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Fondation de l\u2019Institut universitaire de cardiologie et de pneumologie de Quebec"},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes for Health Research","doi-asserted-by":"crossref","award":["Early Career Investigator Award"],"award-info":[{"award-number":["Early Career Investigator Award"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2022,5,26]]},"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Myocardial infarction (MI) has been shown to induce fibrotic remodelling of the mitral and tricuspid valves. It is unknown whether MI also induces pathological remodelling of the aortic valve and alters aortic stenosis (AS) progression. We thus compared AS progression after an acute MI and in patients with\/without history of MI, and assessed post-MI pathobiological changes within the aortic valve leaflets in a sheep model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Serial echocardiograms in human patients with AS were retrospectively analysed and compared between 3 groups: (1) acute MI at baseline (n=68), (2) prior history of MI (n=45) and (3) controls without MI (n=101). Annualised progression rates of AS severity were compared between these 3 groups. In addition, aortic valves were harvested from 15 sheep: (1) induced inferior MI (n=10) and (2) controls without MI (n=5), for biological and histological analyses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In humans, the acute MI, previous MI and control groups had comparable baseline AS severity. Indexed aortic valve area (AVA<jats:sub>i<\/jats:sub>) declined faster in the acute MI group compared with controls (\u22120.07\u00b10.06 vs \u22120.04\u00b10.04 cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>\/year; p=0.004). After adjustment, acute MI status was significantly associated with faster AVA<jats:sub>i<\/jats:sub> progression (mean difference: \u22120.013 (95% CI \u22120.023 to \u22120.003) cm<jats:sup>2<\/jats:sup>\/m<jats:sup>2<\/jats:sup>\/year, p=0.008). In the post-MI experimental animal model, aortic valve thickness and qualitative\/quantitative expression of collagen were significantly increased compared with controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The results of this study suggest that AS progression is accelerated following acute MI, which could be caused by increased collagen production and thickening of the aortic valve after the ischaemic event.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2022-002046","type":"journal-article","created":{"date-parts":[[2022,6,21]],"date-time":"2022-06-21T11:21:13Z","timestamp":1655810473000},"page":"e002046","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Progression of aortic stenosis after an acute myocardial infarction"],"prefix":"10.1136","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2034-4196","authenticated-orcid":false,"given":"Am\u00e9lie","family":"Paquin","sequence":"first","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec City, Qu\u00e9bec, Canada"},{"name":"Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ons","family":"Marsit","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Desch\u00eanes","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dounia","family":"Rouabhia","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hadjadj","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marine","family":"Clisson","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charlotte","family":"Robitaille","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7835-2135","authenticated-orcid":false,"given":"Elena","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A","family":"Levine","sequence":"additional","affiliation":[{"name":"Cardiac Ultrasound Lab, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3607-279X","authenticated-orcid":false,"given":"Philippe","family":"Pibarot","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Annick","family":"Clavel","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Beaudoin","sequence":"additional","affiliation":[{"name":"Qu\u00e9bec Heart and Lung Institute, Laval University, Qu\u00e9bec City, Qu\u00e9bec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,6,21]]},"reference":[{"key":"2025081710352400000_9.1.e002046.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(06)69208-8"},{"key":"2025081710352400000_9.1.e002046.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.pcad.2014.02.006"},{"key":"2025081710352400000_9.1.e002046.3","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.1038\/nrdp.2016.6","article-title":"Calcific aortic 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Conserved and divergent modulation of calcification in atherosclerosis and aortic valve disease by tissue extracellular vesicles. bioRxiv 2020.","DOI":"10.1101\/2020.04.02.022525"},{"key":"2025081710352400000_9.1.e002046.11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0804602"},{"key":"2025081710352400000_9.1.e002046.12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2015.10.092"},{"key":"2025081710352400000_9.1.e002046.13","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCIMAGING.117.006512","article-title":"Mitral leaflet changes following myocardial infarction: clinical evidence for maladaptive valvular remodeling","volume":"10","author":"Beaudoin","year":"2017","journal-title":"Circ Cardiovasc Imaging"},{"key":"2025081710352400000_9.1.e002046.14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.11.039"},{"key":"2025081710352400000_9.1.e002046.15","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2017.02.009"},{"key":"2025081710352400000_9.1.e002046.16","doi-asserted-by":"publisher","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"2025081710352400000_9.1.e002046.17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcmg.2018.11.004"},{"key":"2025081710352400000_9.1.e002046.18","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.95.9.2262"},{"key":"2025081710352400000_9.1.e002046.19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.07.734"},{"key":"2025081710352400000_9.1.e002046.20","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm543"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2022-002046","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T17:35:34Z","timestamp":1755452134000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2022-002046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,6,21]]},"published-print":{"date-parts":[[2022,6]]}},"alternative-id":["10.1136\/openhrt-2022-002046"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2022-002046","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6]]}}}