{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,21]],"date-time":"2025-08-21T16:54:12Z","timestamp":1755795252133,"version":"3.44.0"},"reference-count":27,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"unspecified","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2023,1,20]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:p>\n                  <jats:bold>Objective<\/jats:bold>\n               <\/jats:p>\n               <jats:p>Sarcoidosis is over-represented among victims of cardiac arrest. We aimed to establish whether sarcoidosis is associated with out-of-hospital cardiac arrest (OHCA) in the general population.<\/jats:p>\n               <jats:p>\n                  <jats:bold>Methods<\/jats:bold>\n               <\/jats:p>\n               <jats:p>We conducted a nested case\u2013control study in a nationwide cohort of individuals between 1 June 2001 and 31 December 2015 in Denmark. OHCA cases from presumed cardiac causes were matched 1:10 by sex and age on OHCA date with non-OHCA controls from the general population. The association between sarcoidosis and OHCA was assessed using Cox regression by calculating HR and 95% CIs. Models were adjusted for cardiovascular disease. Finally, stratified analyses were performed according to sex, heart failure and ischaemic heart disease.<\/jats:p>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We identified 35\u2009195 OHCA cases and 351\u2009950 matched controls without OHCA (median age 72 years and 66.8% male). Patients with sarcoidosis had higher rate of OHCA compared with the general population after adjustments for common OHCA risk factors (HR 1.51, 95%\u2009CI 1.19 to 1.92). This increased OHCA rate occurred in women (HR 2.11, 95%\u2009CI 1.42 to 3.12) but not in men (HR 1.27, 95%\u2009CI 0.93 to 1.72; p value interaction=0.033), and was larger in patients with than without heart failure (HR<jats:sub>heart failure<\/jats:sub>: 2.59, 95%\u2009CI 1.42 to 4.73; HR<jats:sub>no heart failure<\/jats:sub>: 1.33, 95%\u2009CI 1.01 to 1.74; p value interaction: 0.007). The HR associated with sarcoidosis did not vary by the presence of ischaemic heart disease.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Patients with sarcoidosis have a higher OHCA rate than the general population. This increased OHCA rate occurred in women but not in men, and was larger in patients with than without heart failure.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2022-002088","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T10:00:40Z","timestamp":1675936840000},"page":"e002088","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Risk of out-of-hospital cardiac arrest in patients with sarcoidosis: a Danish nationwide nested case\u2013control study"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4381-0068","authenticated-orcid":false,"given":"Talip E","family":"Eroglu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Herlev and Gentofte, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredrik","family":"Folke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Herlev and Gentofte, Copenhagen, Denmark"},{"name":"Copenhagen University Hospital \u2013 Copenhagen Emergency Medical Services, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruben","family":"Coronel","sequence":"additional","affiliation":[{"name":"Department of Experimental and Clinical Cardiology, Amsterdam UMC Locatie AMC, Amsterdam, Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Torp-Pedersen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark"},{"name":"Department of Cardiology, Nordsj\u00e6llands Hospital, Hillerod, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunnar Hilmar","family":"Gislason","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital \u2013 Herlev and Gentofte, Copenhagen, Denmark"},{"name":"The Danish Heart Foundation, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"2025081709295913000_10.1.e002088.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.111.023838"},{"key":"2025081709295913000_10.1.e002088.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra000650"},{"key":"2025081709295913000_10.1.e002088.3","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.116.304521"},{"key":"2025081709295913000_10.1.e002088.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60680-7"},{"key":"2025081709295913000_10.1.e002088.5","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2011.93"},{"key":"2025081709295913000_10.1.e002088.6","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1056\/NEJMra2101555","article-title":"Challenges of sarcoidosis and its management","volume":"385","author":"Drent","year":"2021","journal-title":"N Engl J Med"},{"key":"2025081709295913000_10.1.e002088.7","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.ccm.2015.08.008","article-title":"Cardiac sarcoidosis","volume":"36","author":"Birnie","year":"2015","journal-title":"Clin Chest Med"},{"key":"2025081709295913000_10.1.e002088.8","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.58.6.1204"},{"key":"2025081709295913000_10.1.e002088.9","doi-asserted-by":"publisher","DOI":"10.1378\/chest.07-2784"},{"key":"2025081709295913000_10.1.e002088.10","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01290-2016","article-title":"Risk of cardiovascular disease among patients with sarcoidosis: a population-based retrospective cohort study, 1976-2013","volume":"49","author":"Ungprasert","year":"2017","journal-title":"Eur Respir J"},{"key":"2025081709295913000_10.1.e002088.11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijcard.2016.11.041","article-title":"Increased risk of ventricular tachycardia in patients with sarcoidosis during the very long term follow-up","volume":"228","author":"Te","year":"2017","journal-title":"Int J Cardiol"},{"key":"2025081709295913000_10.1.e002088.12","doi-asserted-by":"crossref","first-page":"330","DOI":"10.21037\/atm.2018.07.33","article-title":"The burden of cardiac arrhythmias in sarcoidosis: a population-based inpatient analysis","volume":"6","author":"Desai","year":"2018","journal-title":"Ann Transl Med"},{"key":"2025081709295913000_10.1.e002088.13","doi-asserted-by":"crossref","first-page":"272","DOI":"10.5603\/CJ.a2018.0104","article-title":"Cardiac sarcoidosis and ventricular arrhythmias. 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