{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T08:56:59Z","timestamp":1758272219153,"version":"3.44.0"},"reference-count":21,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T00:00:00Z","timestamp":1690502400000},"content-version":"unspecified","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2023,6,30]]},"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The incidence of arrhythmia in heart failure with non-reduced ejection fraction (HFnon-rEF) in patients who have a history of hospitalisation is unclear. The aim of this study is to investigate the usefulness of an implantable loop recorder (ILR) for arrhythmia detection including atrial fibrillation (AF) in HFnon-rEF patients after discharge.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>This is a multicentre single arm study to evaluate the usefulness of ILR for detecting arrhythmia. The eligible patients are HFnon-rEF patients (left ventricular ejection fraction \u226540%) aged \u226520 years with a history of hospitalisation. The ILR will be implanted for qualified patients, and ECGs will be monitored and recorded for 1\u2009year to check for arrhythmias. The primary endpoint is new-onset 6\u2009min or more persistent AF detected by ILR. Secondary endpoints are 30\u2009s or more persistent supraventricular tachycardia and ventricular tachycardia, 3\u2009s or more persistent pause, bradycardia with 40 beats per minutes or lower heart rate, AF burden, all-cause death, cardiovascular death, hospital readmission due to exacerbation of HF, acute coronary syndrome, ischaemic or haemorrhagic stroke, non-pharmacological therapy such as pacemaker implantation and ablation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study is expected to provide valuable findings regarding arrhythmia in HFnon-rEF patients, and elucidate a potential new therapeutic approach for HFnon-rEF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>This trial has been registered in the Japan Registry of Clinical Trials (jRCT) (Trial Registration: jRCTs052210060).<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2022-002193","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T13:00:12Z","timestamp":1690549212000},"page":"e002193","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Rationale and design of the NEO-NORMAL-AF study examination of the usefulness of implantable loop recorder for arrhythmia detection including atrial fibrillation in heart failure with non-reduced ejection fraction cases: a pilot study"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1746-1842","authenticated-orcid":false,"given":"Junichi","family":"Sugiura","sequence":"first","affiliation":[{"name":"Cardiovascular Medicine, Nara Medical University, Kashihara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syu","family":"Kasama","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Science, Nara Medical University, Kashihara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Ueda","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, Nara Medical University, Kashihara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Nishida","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, Nara Medical University, Kashihara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Kawata","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, Nara Prefecture General Medical Center, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manabu","family":"Horii","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, Nara City Hospital, Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Ozu","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Science, Nara Medical University, Kashihara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masato","family":"Kasahara","sequence":"additional","affiliation":[{"name":"Institute for Clinical and Translational Science, Nara Medical University, Kashihara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Saito","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine, Nara Medical University, Kashihara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,7,28]]},"reference":[{"key":"2025081711074429000_10.2.e002193.1","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1253\/circj.72.489","article-title":"Impending epidemic: future projection of heart failure in Japan to the year 2055","volume":"72","author":"Okura","year":"2008","journal-title":"Circ J"},{"key":"2025081711074429000_10.2.e002193.2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"2025081711074429000_10.2.e002193.3","unstructured":"Tsutsui Kitaoka. 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