{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T07:33:04Z","timestamp":1784014384772,"version":"3.55.0"},"reference-count":12,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T00:00:00Z","timestamp":1678924800000},"content-version":"unspecified","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2023,3,2]]},"published-print":{"date-parts":[[2023,3]]},"abstract":"\n Objectives<\/jats:title>\n Worldwide, an estimated 10 million adults annually experience significant myocardial injury after non-cardiac surgery. Our aim is to assess whether preoperative and postoperative serum B-type natriuretic peptides levels (BNP) could be used as a predictor of postoperative complications in hypertensive and diabetic patients post non-cardiac surgery.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n Prospective observational study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n Single tertiary-care centre in northern India.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n This study included 260 adult participants with known hypertension and diabetes who were planned for elective non-cardiac surgery.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n A preoperative BNP level (baseline BNP) was measured within 24 hours of surgery and another postoperative BNP level was measured within 24 hours of surgery.<\/jats:p>\n <\/jats:sec>\n \n Main outcome measures<\/jats:title>\n The primary outcome was the change in BNP levels (delta BNP) between the postoperative and the preoperative BNP levels (baseline BNP) with respect to the baseline BNP and the development of postoperative complications within 30 days of surgery.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The study established a correlation between delta BNP and baseline BNP (Pearson\u2019s correlation coefficient=0.60; p=0.01). Our study found an increased serum BNP both in the preoperative period and the postoperative period in the patient group that developed complications, respectively (152.02 pg\/mL\u00b1106.56 vs 44.90 pg\/mL\u00b144.22; t=4.120; p\u22640.001); (313.99 pg\/mL\u00b1121.29 vs 83.95 pg\/mL\u00b170.19; t=7.73; p\u22640.001).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n We found that an increased serum baseline and postoperative BNP is potentially important predictor for the development of postoperative complications. Serum BNP has the potential to emerge as a cost-effective test for risk-stratification for postoperative complications in patients undergoing non-cardiac surgery. It has promising prognostic advantages including modification of surgical procedures, deferral of surgery and the ability to tailor therapy postoperatively.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/openhrt-2023-002256","type":"journal-article","created":{"date-parts":[[2023,3,16]],"date-time":"2023-03-16T10:50:47Z","timestamp":1678963847000},"page":"e002256","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Serum B-type natriuretic peptide levels (BNP) can be used as a predictor of complications in patients undergoing non-cardiac surgery: a prospective observational study"],"prefix":"10.1136","volume":"10","author":[{"given":"Abhishek","family":"Singh","sequence":"first","affiliation":[{"name":"General Surgery, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8271-5784","authenticated-orcid":false,"given":"Anil","family":"Kumar","sequence":"additional","affiliation":[{"name":"Trauma Surgery & Critical Care, All India Institute of Medical Sciences, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Abdul","family":"Hai","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Paras HMRI Hospital, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masihullah","family":"Masihullah","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Paras HMRI Hospital, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Tripathy","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Paras HMRI, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pintu Kumar","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Paras HMRI Hospital, Patna, Bihar, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,3,16]]},"reference":[{"key":"2025081710390953000_10.1.e002256.1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2017.4360"},{"key":"2025081710390953000_10.1.e002256.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2011.04.018"},{"key":"2025081710390953000_10.1.e002256.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2009.06.028"},{"key":"2025081710390953000_10.1.e002256.4","doi-asserted-by":"crossref","first-page":"338","DOI":"10.7196\/SAMJ.2021.v111i4.15226","article-title":"A prospective observational study of preoperative natriuretic peptide testing in adult non-cardiac surgical patients in hospitals in Western Cape Province, South Africa","volume":"111","author":"Alphonsus","year":"2021","journal-title":"S Afr Med J"},{"key":"2025081710390953000_10.1.e002256.5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2007.11.008"},{"key":"2025081710390953000_10.1.e002256.6","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aem158"},{"key":"2025081710390953000_10.1.e002256.7","doi-asserted-by":"publisher","DOI":"10.1096\/fj.02-0796fje"},{"key":"2025081710390953000_10.1.e002256.8","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehm234"},{"key":"2025081710390953000_10.1.e002256.9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00226.2011"},{"key":"2025081710390953000_10.1.e002256.10","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfn491"},{"key":"2025081710390953000_10.1.e002256.11","doi-asserted-by":"crossref","first-page":"44","DOI":"10.5090\/kjtcs.2011.44.1.44","article-title":"N-Terminal pro-B-type natriuretic peptide is useful to predict cardiac complications following lung resection surgery","volume":"44","author":"Lee","year":"2011","journal-title":"Korean J Thorac Cardiovasc Surg"},{"key":"2025081710390953000_10.1.e002256.12","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aep139"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2023-002256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T17:39:18Z","timestamp":1755452358000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2023-002256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":12,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,3,16]]},"published-print":{"date-parts":[[2023,3]]}},"alternative-id":["10.1136\/openhrt-2023-002256"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2023-002256","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3]]}}}