{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:24:44Z","timestamp":1790735084743,"version":"4.1.0"},"reference-count":30,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T00:00:00Z","timestamp":1687996800000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015756","name":"Janssen-Cilag","doi-asserted-by":"crossref","award":["Investigator-initiated study research grant"],"award-info":[{"award-number":["Investigator-initiated study research grant"]}],"id":[{"id":"10.13039\/100015756","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Heart Centre Research Council of Rigshospitalet"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2023,6,2]]},"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Current multimodal risk assessment for pulmonary hypertension (PH) has been redefined with a simplified assessment for follow-up in the new European Society of Cardiology\/European Respiratory Society (ESC\/ERS) guidelines. Follow-up risk assessment parameters include WHO functional class, 6\u2009min walk test and N-terminal pro-brain natriuretic peptide. Although these parameters have prognostic implications assessment reflect data relating to specific time points.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients diagnosed with PH received an implantable loop recorder (ILR) to monitor daytime and night-time heart rate (HR), HR variability (HRV) and daily physical activity. Associations between the ILR measurements and established risk parameters were analysed using correlations, linear mixed models as well as logistical mixed models for addressing the ESC\/ERS risk-score.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>41 patients (median age: 56 years, range: 44\u201361.5 years) were included. Continuous monitoring had a median duration of 755 days (range: 343\u20131138\u2009days), totalling 96 patient-years. In the linear mixed models, HRV and physical activity indexed by daytime HR (PAiHR) were significantly associated with the ERS\/ERC risk parameters. In a logistical mixed model, HRV revealed a significant difference between 1-year mortality (&lt;5%\u2009vs &gt;5%) (p=0.027) with an OR of 0.82 for being in the group with 1-year mortality &gt;5% for every increase by one HRV unit.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Risk assessment in PH can be refined with continuous monitoring of HRV and PAiHR. These markers were associated with the ESC\/ERC parameters. Our study with continuous risk stratification in PH demonstrated that a lower HRV predict worse prognosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2023-002302","type":"journal-article","created":{"date-parts":[[2023,6,29]],"date-time":"2023-06-29T14:05:23Z","timestamp":1688047523000},"page":"e002302","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":13,"title":["Continuous long-term heart rate variability and risk assessment in pulmonary hypertension"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8834-3152","authenticated-orcid":false,"given":"Mads \u00d8rb\u00e6k","family":"Andersen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soren Z\u00f6ga","family":"Diederichsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper Hastrup","family":"Svendsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f8rn","family":"Carlsen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital - Rigshospitalet, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,6,29]]},"reference":[{"key":"2025081711103597000_10.1.e002302.1","doi-asserted-by":"crossref","first-page":"3618","DOI":"10.1093\/eurheartj\/ehac237","article-title":"2022 ESC\/ERS guidelines for the diagnosis and treatment of pulmonary hypertension","volume":"43","author":"Humbert","year":"2022","journal-title":"Eur Heart J"},{"key":"2025081711103597000_10.1.e002302.2","doi-asserted-by":"publisher","DOI":"10.1007\/s41030-019-00105-5"},{"key":"2025081711103597000_10.1.e002302.3","doi-asserted-by":"publisher","DOI":"10.1378\/chest.11-0676"},{"key":"2025081711103597000_10.1.e002302.4","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00009011"},{"key":"2025081711103597000_10.1.e002302.5","unstructured":"Hoeper MM , Pausch C , Olsson KM , et al . 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