{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:47:22Z","timestamp":1793159242822,"version":"4.5.0"},"reference-count":30,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"unspecified","delay-in-days":28,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Leeds Hospital Charity","award":["A2002295"],"award-info":[{"award-number":["A2002295"]}]},{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["CC\/22\/250026"],"award-info":[{"award-number":["CC\/22\/250026"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"name":"British Heart Foundation Clinical Research Training Fellowship","award":["FS\/20\/12\/34789"],"award-info":[{"award-number":["FS\/20\/12\/34789"]}]},{"name":"British Heart Foundation Clinical Research Training Fellowship","award":["MGU0504"],"award-info":[{"award-number":["MGU0504"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2023,9,11]]},"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Atrial fibrillation (AF) is associated with a fivefold increased risk of stroke. Oral anticoagulation reduces the risk of stroke, but AF is elusive. A machine learning algorithm (Future Innovations in Novel Detection of Atrial Fibrillation (FIND-AF)) developed to predict incident AF within 6\u2009months using data in primary care electronic health records (EHRs) could be used to guide AF screening. The objectives of the FIND-AF pilot study are to determine yields of AF during ECG monitoring across AF risk estimates and establish rates of recruitment and protocol adherence in a remote AF screening pathway.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The FIND-AF Pilot is an interventional, non-randomised, single-arm, open-label study that will recruit 1955 participants aged 30 years or older, without a history of AF and eligible for oral anticoagulation, identified as higher risk and lower risk by the FIND-AF risk score from their primary care EHRs, to a period of remote ECG monitoring with a Zenicor-ECG device. The primary outcome is AF diagnosis during ECG monitoring, and secondary outcomes include recruitment rates, withdrawal rates, adherence to ECG monitoring and prescription of oral anticoagulation to participants diagnosed with AF during ECG monitoring.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study has ethical approval (the North West\u2014Greater Manchester South Research Ethics Committee reference 23\/NW\/0180). Findings will be announced at relevant conferences and published in peer-reviewed journals in line with the Funder\u2019s open access policy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05898165\">NCT05898165<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/openhrt-2023-002447","type":"journal-article","created":{"date-parts":[[2023,9,30]],"date-time":"2023-09-30T06:55:19Z","timestamp":1696056919000},"page":"e002447","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":25,"title":["Future Innovations in Novel Detection for Atrial Fibrillation (FIND-AF): pilot study of an electronic health record machine learning algorithm-guided intervention to identify undiagnosed atrial fibrillation"],"prefix":"10.1136","volume":"10","clinical-trial-number":[{"clinical-trial-number":"nct05898165","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05898165","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-9356","authenticated-orcid":false,"given":"Ramesh","family":"Nadarajah","sequence":"first","affiliation":[{"name":"Leeds Institute for Data Analytics, University of Leeds, Leeds, UK"},{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Wahab","sequence":"additional","affiliation":[{"name":"Leeds Institute for Data Analytics, University of Leeds, Leeds, UK"},{"name":"Department of Cardiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Reynolds","sequence":"additional","affiliation":[{"name":"Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keerthenan","family":"Raveendra","sequence":"additional","affiliation":[{"name":"Medical School, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Askham","sequence":"additional","affiliation":[{"name":"Affinity Care Primary Care Network, Bradford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Dawson","sequence":"additional","affiliation":[{"name":"Affinity Care Primary Care Network, Bradford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Keene","sequence":"additional","affiliation":[{"name":"West Leeds Primary Care Network, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sagar","family":"Shanghavi","sequence":"additional","affiliation":[{"name":"LS25\/Primary Care Network, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y H","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science, University of Liverpool, Liverpool, UK"},{"name":"Department of Clinical Medicine, Aalborg University, Aalborg, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Hogg","sequence":"additional","affiliation":[{"name":"School of Computing, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Campbel","family":"Cowan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Leeds General Infirmary, Leeds, 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