{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:05:38Z","timestamp":1792623938886,"version":"4.5.0"},"reference-count":23,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2024,4,16]]},"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The relationship between speckle tracking assessed global longitudinal strain (GLS) and Doppler-based echocardiography with basic physiological markers of cardiac function derived from pressure-volume loops is poorly elucidated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>We aimed to describe the association between LS and Doppler-based echocardiography and direct measurements of central haemodynamic parameters from conductance catheter-based pressure-volume loops in an animal model with increasing left ventricular (LV) dysfunction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>12 Danish landrace female pigs (75\u201380\u2009kg) were used. All instrumentations were performed percutaneously, including the conductance catheter in the LV. Progressive LV dysfunction was induced by embolisation through the left main coronary artery with microspheres every 3\u2009min until a &gt;50% reduction in cardiac output (CO) or mixed venous saturation (SvO<jats:sub>2<\/jats:sub>), compared with baseline, or SvO<jats:sub>2<\/jats:sub> &lt;30%. Echocardiography was performed at baseline and 90\u2009s after each injection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>With progressive LV dysfunction, mean CO decreased from 5.6\u00b10.9\u2009L\/min to 2.1\u00b10.9\u2009L\/min, and mean SvO<jats:sub>2<\/jats:sub> deteriorated from 61.1\u00b17.9%\u2009to 35.3\u00b16.1%. Mean LS and LV outflow tract velocity time integral (LVOT VTI) declined from \u221213.8\u00b13.0%\u2009to \u22126.1\u00b12.0%\u2009and 16.9\u00b12.6\u2009cm to 7.8\u00b11.8\u2009cm, respectively. LS and LVOT VTI showed the strongest correlation to stroke work in unadjusted linear regression (r<jats:sup>2<\/jats:sup>=0.53\u2009and r<jats:sup>2<\/jats:sup>=0.49, respectively). LS correlated significantly with stroke volume, end-systolic elastance, systolic blood pressure, ventriculo-arterial coupling and arterial elastance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>In an animal model of acute progressive LV dysfunction, echocardiographic and conductance catheter-based measurements changed significantly. LS and LVOT VTI displayed the earliest and the largest alterations with increased myocardial damage and both correlated strongest with stroke work.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2023-002512","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T12:50:41Z","timestamp":1716468641000},"page":"e002512","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Association between speckle tracking echocardiography and pressure-volume loops during cardiogenic shock development"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3712-7980","authenticated-orcid":false,"given":"Peter Hartmund","family":"Frederiksen","sequence":"first","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Odense, Denmark"},{"name":"University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Linde","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Odense, Denmark"},{"name":"University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Gregers","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Copenhagen University Hospital, Kobenhavn, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna Louise Junker","family":"Udesen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole K","family":"Helgestad","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"Banke","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Odense, Denmark"},{"name":"University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordi Sanchez","family":"Dahl","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalie L","family":"Povlsen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesiology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisette Okkels","family":"Jensen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Odense, Denmark"},{"name":"University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeppe P","family":"Larsen","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesiology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Lassen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Odense, Denmark"},{"name":"University of Southern Denmark, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic Anaesthesiology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanne Berg","family":"Ravn","sequence":"additional","affiliation":[{"name":"University of Southern Denmark, Odense, Denmark"},{"name":"Department of Cardiothoracic Anaesthesiology, Odense University Hospital, Odense, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2873-5845","authenticated-orcid":false,"given":"Jacob Eifer","family":"Moller","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Odense University Hospital, Odense, Denmark"},{"name":"University of Southern Denmark, Odense, Denmark"},{"name":"Department of Cardiology, Copenhagen University Hospital, Kobenhavn, 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