{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T05:12:30Z","timestamp":1777353150911,"version":"3.51.4"},"reference-count":12,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"unspecified","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2023,11,21]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>This study evaluated the feasibility of His bundle pacing (HBP) in consecutive, unselected patients with advanced atrioventricular block (AVB) over a medium-term follow-up period, comparing procedural characteristics between nodal and infranodal sites of the conduction block.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and methods<\/jats:title>\n                  <jats:p>Seventy-five consecutive patients with second-degree or third-degree AVB in which HBP was attempted were prospectively included in this study. The clinical and procedural-related characteristics of the patients were recorded at baseline and over a mid-term follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>72% of the patients had normal QRS duration at baseline. Intracardiac electrograms revealed nodal AVB in 46 patients (61.3%). The permanent HBP procedural success was significantly higher in nodal AVB (84.8%) vs infranodal AVB (31%). There was no statistical difference between paced QRS duration, impedance, pacing and sensing thresholds and fluoroscopy time in the two groups. Infranodal block, baseline QRS duration, left bundle branch block morphology and ejection fraction were significantly associated with HBP procedural failure. The patients were followed for a period of 627.71\u00b1160.93\u2009days. There were no significant differences in parameters at follow-up. An increase of &gt;1 V in the His bundle (HB) capture threshold was encountered in one patient with infranodal AVB (11.1 %) and in four patients with nodal AVB (10.25%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Permanent HBP is a feasible pacing technique in nodal AVB with a high success rate and stable thresholds in the medium term. Most infranodal blocks are located within the HB, so there is still the possibility to capture the conduction system, although with lower success rates.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2023-002542","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T12:52:26Z","timestamp":1701867146000},"page":"e002542","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["His bundle pacing in nodal versus infranodal atrioventricular block: a mid-term follow-up study"],"prefix":"10.1136","volume":"10","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0840-1736","authenticated-orcid":false,"given":"Catalin","family":"Pestrea","sequence":"first","affiliation":[{"name":"Department of Interventional Cardiology, Brasov County Emergency Hospital, Brasov, Romania"},{"name":"5th Department of Internal Medicine, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ecaterina","family":"Cicala","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Brasov County Emergency Hospital, Brasov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Gherghina","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Brasov County Emergency Hospital, Brasov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florin","family":"Ortan","sequence":"additional","affiliation":[{"name":"Department of Interventional Cardiology, Brasov County Emergency Hospital, Brasov, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana","family":"Pop","sequence":"additional","affiliation":[{"name":"5th Department of Internal Medicine, Iuliu Ha\u021bieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania"},{"name":"Department of Cardiology, Rehabilitation Hospital Cluj-Napoca, Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"2025081709363914000_10.2.e002542.1","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1016\/j.hrthm.2016.09.027","article-title":"Incidence and predictors of right ventricular pacing-induced cardiomyopathy in patients with complete atrioventricular block and preserved left ventricular systolic function","volume":"13","author":"Kiehl","year":"2016","journal-title":"Heart Rhythm"},{"key":"2025081709363914000_10.2.e002542.2","doi-asserted-by":"publisher","DOI":"10.1007\/s00392-021-01927-7"},{"key":"2025081709363914000_10.2.e002542.3","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1111\/jce.14063","article-title":"Long term performance and safety of his bundle pacing: A multicenter experience","volume":"30","author":"Zanon","year":"2019","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2025081709363914000_10.2.e002542.4","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1016\/j.hrthm.2023.03.1538","article-title":"2023 HRS\/APHRS\/LAHRS guideline on cardiac physiologic pacing for the avoidance and mitigation of heart failure","volume":"20","author":"Chung","year":"2023","journal-title":"Heart Rhythm"},{"key":"2025081709363914000_10.2.e002542.5","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.hrthm.2017.10.039","article-title":"Permanent his bundle pacing: recommendations from a multicenter his bundle pacing collaborative working group for standardization of definitions, implant measurements, and follow-up","volume":"15","author":"Vijayaraman","year":"2018","journal-title":"Heart Rhythm"},{"key":"2025081709363914000_10.2.e002542.6","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1111\/jce.14064","article-title":"His bundle pacing, learning curve, procedure characteristics, safety, and feasibility: insights from a large International observational study","volume":"30","author":"Keene","year":"2019","journal-title":"J Cardiovasc Electrophysiol"},{"key":"2025081709363914000_10.2.e002542.7","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jacep.2021.07.007","article-title":"His-Purkinje conduction system pacing in atrioventricular block: new insights into site of conduction block","volume":"8","author":"Vijayaraman","year":"2022","journal-title":"JACC Clin Electrophysiol"},{"key":"2025081709363914000_10.2.e002542.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacep.2015.09.012"},{"key":"2025081709363914000_10.2.e002542.9","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00637.2003"},{"key":"2025081709363914000_10.2.e002542.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2019.04.026"},{"key":"2025081709363914000_10.2.e002542.11","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038648"},{"key":"2025081709363914000_10.2.e002542.12","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1093\/europace\/euaa350","article-title":"His bundle pacing capture threshold stability during long-term follow-up and correlation with lead slack","volume":"23","author":"Beer","year":"2021","journal-title":"Europace"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2023-002542","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,17]],"date-time":"2025-08-17T16:36:48Z","timestamp":1755448608000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2023-002542"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":12,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,12,6]]},"published-print":{"date-parts":[[2023,12]]}},"alternative-id":["10.1136\/openhrt-2023-002542"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2023-002542","relation":{},"ISSN":["2053-3624"],"issn-type":[{"value":"2053-3624","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12]]}}}