{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T21:22:03Z","timestamp":1740172923692,"version":"3.37.3"},"reference-count":29,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T00:00:00Z","timestamp":1708560000000},"content-version":"unspecified","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"swiss personalized health network","award":["2018DRI01"],"award-info":[{"award-number":["2018DRI01"]}]},{"DOI":"10.13039\/501100024021","name":"Facult\u00e9 de Biologie et de M\u00e9decine, Universit\u00e9 de Lausanne","doi-asserted-by":"publisher","award":["33CS30_177535"],"award-info":[{"award-number":["33CS30_177535"]}],"id":[{"id":"10.13039\/501100024021","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["3247730_204523"],"award-info":[{"award-number":["3247730_204523"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["33CSCO-122661"],"award-info":[{"award-number":["33CSCO-122661"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2024,1,31]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>High blood pressure (BP) is a major risk factor for cardiovascular disease (CVD). Adequate treatment of high BP should reduce the risk of CVD, but this association has seldom been assessed in a general population setting.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Population-based prospective study conducted in Lausanne, Switzerland, with a follow-up between 2003 and 2021. Participants were categorised as normal BP, untreated high BP, treated and uncontrolled BP and treated and controlled BP. Total and CVD mortality as well as any CVD event were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>5341 participants (65% normal, 17.4% untreated, 8.8% treated and uncontrolled and 8.8% treated and controlled) were included. After a median follow-up of 14 years (IQR: 11\u201315), 575 CVD events occurred. Relative to participants with normal BP, multivariable-adjusted HRs (and 95% CI) for total CVD were 1.38 (1.11 to 1.72) for untreated, 1.35 (1.04 to 1.76) for treated and uncontrolled and 1.50 (1.15 to 1.95) for treated and controlled. The corresponding HRs for CVD mortality (112 events) were 0.94 (0.52 to 1.70), 1.77 (1.00 to 3.12) and 2.52 (1.50 to 4.23), respectively. For total mortality (677 events), the HRs were 1.24 (1.01 to 1.52), 1.26 (0.99 to 1.60) and 1.27 (0.99 to 1.62), respectively. Sensitivity analysis using BP status during a 5-year period and categorising participants as always normal, always treated and uncontrolled, always treated and controlled and other led to similar findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Over a long follow-up period of 14 years, BP control was not associated with reduction of CVD events, CVD-related or total mortality. This finding should help define further studies on factors affecting CVD and mortality in people treated for hypertension in the general population.<\/jats:p><\/jats:sec>","DOI":"10.1136\/openhrt-2023-002556","type":"journal-article","created":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T02:30:30Z","timestamp":1717295430000},"page":"e002556","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Blood pressure status, trajectories and cardiovascular disease: the CoLaus|PsyCoLaus prospective study"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3351-5126","authenticated-orcid":false,"given":"Yaniv","family":"Chocron","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markos","family":"Rousakis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vollenweider","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julien","family":"Vaucher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro-Manuel","family":"Marques-Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,2,22]]},"reference":[{"key":"2024053113435397000_11.1.e002556.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32152-9"},{"key":"2024053113435397000_11.1.e002556.2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehy339"},{"key":"2024053113435397000_11.1.e002556.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31145-6"},{"key":"2024053113435397000_11.1.e002556.4","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30955-9"},{"key":"2024053113435397000_11.1.e002556.5","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/S2468-2667(18)30210-X","article-title":"Burden of hypertension and associated risks for cardiovascular mortality in Cuba: a prospective cohort study","volume":"4","author":"Armas Rojas","year":"2019","journal-title":"Lancet Public Health"},{"key":"2024053113435397000_11.1.e002556.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01225-8"},{"key":"2024053113435397000_11.1.e002556.7","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2020-318193"},{"key":"2024053113435397000_11.1.e002556.8","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1001\/jamainternmed.2018.4684","article-title":"Benefits and harms of antihypertensive treatment in low-risk patients with mild hypertension","volume":"178","author":"Sheppard","year":"2018","journal-title":"JAMA Intern Med"},{"key":"2024053113435397000_11.1.e002556.9","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1001725"},{"key":"2024053113435397000_11.1.e002556.10","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2261-8-6","article-title":"The Colaus study: a population-based study to investigate the epidemiology and genetic determinants of cardiovascular risk factors and metabolic syndrome","volume":"8","author":"Firmann","year":"2008","journal-title":"BMC Cardiovasc Disord"},{"key":"2024053113435397000_11.1.e002556.11","doi-asserted-by":"publisher","DOI":"10.1097\/00004872-200306000-00001"},{"key":"2024053113435397000_11.1.e002556.12","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1177\/2047487320906305","article-title":"Comparison of Swiss and European risk Algorithms for cardiovascular prevention in Switzerland","volume":"28","author":"Beuret","year":"2021","journal-title":"Eur J Prev Cardiol"},{"key":"2024053113435397000_11.1.e002556.13","first-page":"5","article-title":"\u201cWhat is moderate drinking? defining \"drinks\" and drinking levels\u201d","volume":"23","author":"Dufour","year":"1999","journal-title":"Alcohol Res Health"},{"key":"2024053113435397000_11.1.e002556.14","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009303"},{"key":"2024053113435397000_11.1.e002556.15","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-27377-2","article-title":"Uncontrolled hypertension increases risk of all-cause and cardiovascular disease mortality in US adults: the NHANES III linked mortality study","volume":"8","author":"Zhou","year":"2018","journal-title":"Sci Rep"},{"key":"2024053113435397000_11.1.e002556.16","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/ije\/dyab116","article-title":"Are competing-risk models superior to standard Cox models for predicting cardiovascular risk in older adults? analysis of a whole-of-country primary prevention cohort aged >\/=65 years","volume":"51","author":"Cooper","year":"2022","journal-title":"Int J Epidemiol"},{"key":"2024053113435397000_11.1.e002556.17","doi-asserted-by":"publisher","DOI":"10.1038\/jhh.2013.22"},{"key":"2024053113435397000_11.1.e002556.18","doi-asserted-by":"publisher","DOI":"10.1097\/01.hjh.0000187261.40190.2e"},{"key":"2024053113435397000_11.1.e002556.19","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1080\/00325481.2023.2210934","article-title":"Possible cardiovascular risks of white coat hypertension: updated","volume":"135","author":"Chrysant","year":"2023","journal-title":"Postgrad Med"},{"key":"2024053113435397000_11.1.e002556.20","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1111\/jch.13722","article-title":"Blood pressure in relation to frailty in older adults: A population-based study","volume":"21","author":"Anker","year":"2019","journal-title":"J Clin Hypertens (Greenwich)"},{"key":"2024053113435397000_11.1.e002556.21","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/ajh\/hpx028","article-title":"Association of blood pressure trajectory with mortality, incident cardiovascular disease, and heart failure in the cardiovascular health study","volume":"30","author":"Smitson","year":"2017","journal-title":"Am J Hypertens"},{"key":"2024053113435397000_11.1.e002556.22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.07.754"},{"key":"2024053113435397000_11.1.e002556.23","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1111\/ene.13411","article-title":"Post-stroke diastolic blood pressure and risk of recurrent vascular events","volume":"24","author":"Park","year":"2017","journal-title":"Eur J Neurol"},{"key":"2024053113435397000_11.1.e002556.24","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1093\/ajh\/hpab059","article-title":"Trajectories of blood pressure control a year after randomization and incident cardiovascular outcomes in SPRINT","volume":"34","author":"German","year":"2021","journal-title":"Am J Hypertens"},{"key":"2024053113435397000_11.1.e002556.25","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2013-003423","article-title":"Hypertension prevalence, awareness, treatment and control in national surveys from England, the USA and Canada, and correlation with stroke and ischaemic heart disease mortality: a cross-sectional study","volume":"3","author":"Joffres","year":"2013","journal-title":"BMJ Open"},{"key":"2024053113435397000_11.1.e002556.26","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jhh.1000426"},{"key":"2024053113435397000_11.1.e002556.27","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.026687"},{"key":"2024053113435397000_11.1.e002556.28","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1161\/HYPERTENSIONAHA.117.09479","article-title":"Blood pressure Trajectories and the risk of intracerebral hemorrhage and cerebral infarction: A prospective study","volume":"70","author":"Li","year":"2017","journal-title":"Hypertension"},{"key":"2024053113435397000_11.1.e002556.29","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07098"}],"container-title":["Open Heart"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/openhrt-2023-002556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,2]],"date-time":"2024-06-02T02:30:40Z","timestamp":1717295440000},"score":1,"resource":{"primary":{"URL":"https:\/\/openheart.bmj.com\/lookup\/doi\/10.1136\/openhrt-2023-002556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":29,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,2,22]]},"published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1136\/openhrt-2023-002556"],"URL":"https:\/\/doi.org\/10.1136\/openhrt-2023-002556","relation":{},"ISSN":["2053-3624"],"issn-type":[{"type":"electronic","value":"2053-3624"}],"subject":[],"published":{"date-parts":[[2024,2]]}}}