{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:42:02Z","timestamp":1790786522674,"version":"4.1.0"},"reference-count":17,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:00:00Z","timestamp":1709078400000},"content-version":"unspecified","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Abbott Medical"},{"name":"Boston Scientific"},{"name":"Medtronic"},{"DOI":"10.13039\/100006520","name":"Edwards Lifesciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006520","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002973","name":"Daiichi-Sankyo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002973","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2024,2,15]]},"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The clinical outcomes of transcatheter aortic valve replacement (TAVR) in patients with aortic stenosis (AS) and concomitant active cancer remain insufficiently explored. This study aimed to assess the midterm outcomes of TAVR in patients diagnosed with AS and active cancer.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data from the OCEAN-TAVI, a prospective Japanese registry of TAVR procedures, was analysed to compare prognoses and clinical outcomes in patients with and without active cancer at the time of TAVR.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 2336 patients who underwent TAVR from October 2013 to July 2017, 89 patients (3.8%) had active cancer, whereas 2247 did not. Among patients with active cancer, 49 had limited-stage cancer (stage 1 or 2). The prevalent cancers identified before TAVR were colon (21%), prostate (18%), lung (15%), liver (11%) and breast (9%). Although the periprocedural complications and 30-day mortality rates were comparable between the groups, the 3-year survival rate after TAVR was notably lower in patients with active cancer (64.7%) than in those without active cancer (74.7%; p=0.016). Nevertheless, the 3-year survival rate of patients with limited-stage cancer (stage 1 or 2) did not significantly differ from those without cancer (70.6% vs 74.7%, p=0.50).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The patients with active cancer exhibited significantly reduced midterm survival rates. However, no distinct disparity existed in those with limited-stage cancer (stage 1 or 2). Although TAVR is a viable treatment in patients with AS with active cancer, the type and stage of cancer and prognosis should be carefully weighed in the decision-making process.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2023-002573","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T00:21:08Z","timestamp":1709079668000},"page":"e002573","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Midterm outcomes of transcatheter aortic valve replacement in patients with active cancer"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-3449","authenticated-orcid":false,"given":"Masahiko","family":"Noguchi","sequence":"first","affiliation":[{"name":"Department of Cardiology, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Tabata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Japan"},{"name":"Department of Cardiovascular Surgery, Juntendo University Graduate School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joji","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nahoko","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kotaro","family":"Obunai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Bay Urayasu Ichikawa Medical Center, Urayasu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7755-5771","authenticated-orcid":false,"given":"Fumiaki","family":"Yashima","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Utsunomiya Hospital, Utsunomiya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2297-5303","authenticated-orcid":false,"given":"Yusuke","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Teikyo University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Naganuma","sequence":"additional","affiliation":[{"name":"Department of Cardiology, New Tokyo Hospital, Matsudo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Yamawaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Yokohama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7948-9915","authenticated-orcid":false,"given":"Futoshi","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shonan Kamakura General Hospital, Kamakura, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichi","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital, Kitakyushu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Ueno","sequence":"additional","affiliation":[{"name":"Second Department of Internal Medicine, Toyama University Hospital, Toyama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norio","family":"Tada","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sendai Kosei Hospital, Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5210-6382","authenticated-orcid":false,"given":"Masanori","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan"},{"name":"Department of Cardiology, Nagoya Heart Center, Nagoya, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Hayashida","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Keio University School of Medicine, Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,2,27]]},"reference":[{"key":"2025081710211871000_11.1.e002573.1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1008232"},{"key":"2025081710211871000_11.1.e002573.2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1103510"},{"key":"2025081710211871000_11.1.e002573.3","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1514616"},{"key":"2025081710211871000_11.1.e002573.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1700456"},{"key":"2025081710211871000_11.1.e002573.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1814052"},{"key":"2025081710211871000_11.1.e002573.6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1816885"},{"key":"2025081710211871000_11.1.e002573.7","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000923"},{"key":"2025081710211871000_11.1.e002573.8","first-page":"561","article-title":"ESC\/EACTS guidelines for the management of valvular heart disease","volume":"62","author":"Beyersdorf","year":"2022","journal-title":"Eur Heart J"},{"key":"2025081710211871000_11.1.e002573.9","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.amjcard.2016.05.052","article-title":"Comparison of results of Transcatheter aortic valve implantation in patients with versus without active cancer","volume":"118","author":"Watanabe","year":"2016","journal-title":"Am J Cardiol"},{"key":"2025081710211871000_11.1.e002573.10","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jaccao.2020.05.023","article-title":"Outcomes of cancer patients undergoing Transcatheter aortic valve replacement","volume":"2","author":"Jain","year":"2020","journal-title":"JACC 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Monitoring of cancer incidence in Japan - survival 2009-2011 report. 2020. 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