{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:25:14Z","timestamp":1790115914320,"version":"4.0.1"},"reference-count":27,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T00:00:00Z","timestamp":1711497600000},"content-version":"unspecified","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000274","name":"British Heart Foundation","doi-asserted-by":"publisher","award":["FS\/CRTF\/20\/24022"],"award-info":[{"award-number":["FS\/CRTF\/20\/24022"]}],"id":[{"id":"10.13039\/501100000274","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009032","name":"Pfizer Limited","doi-asserted-by":"crossref","award":["WI246510"],"award-info":[{"award-number":["WI246510"]}],"id":[{"id":"10.13039\/100009032","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2024,3,12]]},"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Transthyretin amyloid cardiomyopathy (ATTR-CM) is an infiltrative cardiac disorder caused by deposition of wild type or mutated transthyretin. As ATTR-CM is associated with conduction disease, we sought to determine its prevalence in patients with idiopathic high-degree atrioventricular (AV) block requiring permanent pacemaker (PPM) implantation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive patients aged 70\u201385 years undergoing PPM implantation for idiopathic high-degree AV block between November 2019 and November 2021 were offered a 3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) scan. Demographics, comorbidities, electrocardiographic and imaging data from the time of device implantation were retrospectively collected.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>39 patients (79.5% male, mean (SD) age at device implantation 76.2 (2.9) years) had a DPD scan. 3\/39 (7.7%, all male) had a result consistent with ATTR-CM (Perugini grade 2 or 3). Mean (SD) maximum wall thickness of those with a positive DPD scan was 19.0\u2009mm (3.6\u2009mm) vs 11.4\u2009mm (2.7\u2009mm) in those with a negative scan (p=0.06). All patients diagnosed with ATTR-CM had spinal canal stenosis and two had carpal tunnel syndrome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ATTR-CM should be considered in older patients requiring permanent pacing for high-degree AV block, particularly in the presence of left ventricular hypertrophy, carpal tunnel syndrome or spinal canal stenosis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2024-002606","type":"journal-article","created":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T13:45:37Z","timestamp":1711547137000},"page":"e002606","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Prevalence of transthyretin cardiac amyloidosis in patients with high-degree AV block"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-922X","authenticated-orcid":false,"given":"Douglas","family":"Cannie","sequence":"first","affiliation":[{"name":"University College London, London, UK"},{"name":"St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kush","family":"Patel","sequence":"additional","affiliation":[{"name":"University College London, London, UK"},{"name":"St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandros","family":"Protonotarios","sequence":"additional","affiliation":[{"name":"University College London, London, UK"},{"name":"St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Imogen","family":"Heenan","sequence":"additional","affiliation":[{"name":"University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-6356-2205","authenticated-orcid":false,"given":"Athanasios","family":"Bakalakos","sequence":"additional","affiliation":[{"name":"University College London, London, UK"},{"name":"St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros","family":"Syrris","sequence":"additional","affiliation":[{"name":"University College London, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon","family":"Menezes","sequence":"additional","affiliation":[{"name":"University College London, London, UK"},{"name":"St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perry M","family":"Elliott","sequence":"additional","affiliation":[{"name":"University College London, London, UK"},{"name":"St Bartholomew\u2019s Hospital, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"2025081711180308000_11.1.e002606.1","doi-asserted-by":"publisher","DOI":"10.1161\/circulationaha.118.038169"},{"key":"2025081711180308000_11.1.e002606.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.06.033"},{"key":"2025081711180308000_11.1.e002606.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2011.12.060"},{"key":"2025081711180308000_11.1.e002606.4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1121005109"},{"key":"2025081711180308000_11.1.e002606.5","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200351179"},{"key":"2025081711180308000_11.1.e002606.6","doi-asserted-by":"publisher","DOI":"10.1021\/bi500171j"},{"key":"2025081711180308000_11.1.e002606.7","doi-asserted-by":"publisher","DOI":"10.3109\/13506129.2015.1063485"},{"key":"2025081711180308000_11.1.e002606.8","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805689"},{"key":"2025081711180308000_11.1.e002606.9","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2020.05.021"},{"key":"2025081711180308000_11.1.e002606.10","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv338"},{"key":"2025081711180308000_11.1.e002606.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2020.04.007"},{"key":"2025081711180308000_11.1.e002606.12","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1002\/ehf2.13110","article-title":"Prevalence of wild type Transtyrethin cardiac Amyloidosis in a heart failure clinic","volume":"8","author":"Lindmark","year":"2021","journal-title":"ESC Heart Fail"},{"key":"2025081711180308000_11.1.e002606.13","doi-asserted-by":"crossref","unstructured":"Scully PR , Treibel TA , Fontana M , et al . 1\u2005A multi-centre study of cardiac Amyloidosis in Tavi patients. 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