{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T20:07:16Z","timestamp":1776283636994,"version":"3.50.1"},"reference-count":22,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"unspecified","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["Open Heart"],"accepted":{"date-parts":[[2024,4,22]]},"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Cardiac involvement in SLE is rare but plays an important prognostic role. The degree of cardiac involvement according to SLE subsets defined by non-cardiac manifestations is unknown. The objective of this study was to identify differences in transthoracic echocardiography (TTE) parameters associated with different SLE subgroups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>One hundred eighty-one patients who fulfilled the 2019 American College of Rheumatology\/EULAR classification criteria for SLE and underwent baseline TTE were included in this cross-sectional study. We defined four subsets of SLE based on the predominant clinical manifestations. A multivariate multinomial regression analysis was performed to determine whether TTE parameters differed between groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Four clinical subsets were defined according to non-cardiac clinical manifestations: group A (n=37 patients) showed features of mixed connective tissue disease, group B (n=76 patients) had primarily cutaneous involvement, group C (n=18) exhibited prominent serositis and group D (n=50) had severe, multi-organ involvement, including notable renal disease. Forty TTE parameters were assessed between groups. Per multivariate multinomial regression analysis, there were statistically significant differences in early diastolic tricuspid annular velocity (RV-Ea, p&lt;0.0001), RV S\u2019 wave (p=0.0031) and RV end-diastolic diameter (p=0.0419) between the groups. Group B (primarily cutaneous involvement) had the lowest degree of RV dysfunction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>When defining clinical phenotypes of SLE based on organ involvement, we found four distinct subgroups which showed notable differences in RV function on TTE. Risk-stratifying patients by clinical phenotype could help better tailor cardiac follow-up in this population.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/openhrt-2024-002615","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T11:25:14Z","timestamp":1714735514000},"page":"e002615","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Heterogeneity of right ventricular echocardiographic parameters in systemic lupus erythematosus among four clinical subgroups, as stratified by clinical organ involvement in observational cohort"],"prefix":"10.1136","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7074-4839","authenticated-orcid":false,"given":"Corentin","family":"Bourg","sequence":"first","affiliation":[{"name":"Departement of Cardiology, CHU Rennes, Rennes, France"},{"name":"Laboratoire du traitement du signal et de l'image LTSI, INSERM UMR 1099, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erwan","family":"Le Tallec","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, University of Rennes 1, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Curtis","sequence":"additional","affiliation":[{"name":"Departement of Cardiology, CHU Rennes, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Lee","sequence":"additional","affiliation":[{"name":"University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Bouzille","sequence":"additional","affiliation":[{"name":"Laboratoire du traitement du signal et de l'image LTSI, INSERM UMR 1099, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Oger","sequence":"additional","affiliation":[{"name":"EA Reperes, CHU Rennes, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alain","family":"Lescort","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Immunology, University of Rennes 1, Rennes, France"},{"name":"Irset (Institut de Recherche en Sant\u00e9 Environnement et Travail)\u2014UMR_S 1085, Rennes, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-3389","authenticated-orcid":false,"given":"Erwan","family":"Donal","sequence":"additional","affiliation":[{"name":"Departement of Cardiology, CHU Rennes, Rennes, France"},{"name":"Laboratoire du traitement du signal et de l'image LTSI, INSERM UMR 1099, Rennes, 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